CAJ | 학술논문

1例37岁男性患者因Ⅲ期鼻咽癌进行同步放化疗联合尼妥珠单抗靶向治疗,第1、6、41、48天分别静脉滴注尼妥珠单抗200 mg+0.9％氯化钠注射液250 ml；第6～51天行调强放疗；第28天起行2个周期同步化疗(顺铂80 mg/m2,分2d静脉滴注,每个周期21 d).首次静脉滴注尼妥珠单抗后第2天患者诉嗅觉丧失,对所有种类气味均不敏感,持续至第57天患者病情缓解出院.出院后1个月复诊,患者自诉可闻及刺激性气味；6个月复诊,自诉嗅觉部分恢复.
1례37세남성환자인Ⅲ기비인암진행동보방화료연합니타주단항파향치료,제1、6、41、48천분별정맥적주니타주단항200 mg+0.9％록화납주사액250 ml；제6～51천행조강방료；제28천기행2개주기동보화료(순박80 mg/m2,분2d정맥적주,매개주기21 d).수차정맥적주니타주단항후제2천환자소후각상실,대소유충류기미균불민감,지속지제57천환자병정완해출원.출원후1개월복진,환자자소가문급자격성기미；6개월복진,자소후각부분회복.
A 37-year-old male underwent the synchronal radiochemotherapy combined with nimotuzumab for stage Ⅲ nasopharyngeal carcinoma.He received an Ⅳ infusion of nimotuzumab 200 mg dissoloved in 0.9％ sodium chloride 250 ml on the first,sixth,forty-first,and forty-eighth days,respectively.The intensity-modulated radiation therapy was given from the sixth day to the fifty-first day.Two cycles of the synchronal chemotherapy [an Ⅳ infusion of cisplatin 80 mg/(m2 · 2 d),3 weeks for a cycle] were given from the twenty-eighth day.The patient reported anosphrasia on the second day after the first Ⅳ infusion of nimotuzumab.The symptom of insensitivity to all kinds of smell lasted till the fifty-seventh day when the patient's condition was improved and he was discharged.The patient reported that he could smell pungent smell one month after discharge for subsequent visit and his olfactory sensation was partly restored on six month's subsequent visit.