CAJ | 학술논문

1例57岁男性胰腺癌患者术后行吉西他滨(1.6g静脉滴注,第1、8天)联合替吉奥胶囊(每粒胶囊含替加氟20 mg、吉美嘧啶5.8 mg及奥替拉西钾19.6 mg,3粒/次,2次/d口服,第1～14天)化疗,21 d为1个周期.用药第3天,患者出现全身烧灼样疼痛,体温最高达39.6℃,四肢及胸背部散发紫红色斑疹.立即停用替吉奥胶囊,吉西他滨继续应用.用药第5天,患者四肢内侧及胸背部出现大面积多型性皮疹,部分皮疹中心出现水泡,部分皮疹呈红色大疱并融合成片,部分大疱破溃、暴露创面；同时伴有口腔黏膜糜烂.给予对症处理,2周后患者皮疹基本消失.1周后行吉西他滨联合氟尿嘧啶化疗2个周期,卡培他滨化疗2个周期,未再出现皮疹.
1례57세남성이선암환자술후행길서타빈(1.6g정맥적주,제1、8천)연합체길오효낭(매립효낭함체가불20 mg、길미밀정5.8 mg급오체랍서갑19.6 mg,3립/차,2차/d구복,제1～14천)화료,21 d위1개주기.용약제3천,환자출현전신소작양동통,체온최고체39.6℃,사지급흉배부산발자홍색반진.립즉정용체길오효낭,길서타빈계속응용.용약제5천,환자사지내측급흉배부출현대면적다형성피진,부분피진중심출현수포,부분피진정홍색대포병융합성편,부분대포파궤、폭로창면；동시반유구강점막미란.급여대증처리,2주후환자피진기본소실.1주후행길서타빈연합불뇨밀정화료2개주기,잡배타빈화료2개주기,미재출현피진.
A 57-year-old male patient with pancreatic cancer received postoperative chemotherapy with an Ⅳ infusion of gemcitabine 1.6 g on days 1 and 8 combined with 3 capsules of tegafur,gimeracil and oteracil potassium orally (each capsule contains tegafur 20 mg,gimeracil 5.8 mg,and oteracil potassium 19.6 mg) twice daily on days 1-14 and one cycle took 21 days.On day 3 of drug use,the patient developed generalized burning pain and his highest temperature reached 39.6 ℃.Sporadic prunosus pruritus appeared in his limbs,chest,and back.Tegafur,gimeracil and oteracil potassium capsules were stopped immediately and gemcitabine was continued.On day 5 of drug use,the inside of his limbs,chest,and back were covered a large area of erythema multiforme,of which experienced vesicular in the center,red bulla fusing into lamella,and rupture and wound exposure,accompanied by erosive oral mucosa at the same time.Symptomatic treatments were given and,two weeks later,the rashes basically subsided.One week later,he received two cycles of combination chemotherapy with gemcitabine and fluorouracil and two cycles of capecitabine for chemotherapy as well and the rashes did not recur.