药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2014年
2期
123-124
,共2页
复方甘草酸苷%低钾血症%横纹肌溶解
複方甘草痠苷%低鉀血癥%橫紋肌溶解
복방감초산감%저갑혈증%횡문기용해
Compound glycyrrhizin%Hypokalemia%Rhabdomyolysis
1例37岁男性因乙型肝炎表面抗原(HBsAg)、e抗体(HBeAb)、核心抗体(HBcAb)阳性和转氨酶升高服用复方甘草酸苷25 mg,3次/d,共1个月.1个月后出现双下肢酸痛、乏力,实验室检查示血钾1.8 mmol/L,肌酸激酶8 378 U/L,考虑是复方甘草酸苷所致低血钾与横纹肌溶解.停用复方甘草酸苷并给予补钾、补液治疗10 d后,血钾升至5.1 mmol/L,肌酸激酶降至450 U/L,肌痛、乏力消失.
1例37歲男性因乙型肝炎錶麵抗原(HBsAg)、e抗體(HBeAb)、覈心抗體(HBcAb)暘性和轉氨酶升高服用複方甘草痠苷25 mg,3次/d,共1箇月.1箇月後齣現雙下肢痠痛、乏力,實驗室檢查示血鉀1.8 mmol/L,肌痠激酶8 378 U/L,攷慮是複方甘草痠苷所緻低血鉀與橫紋肌溶解.停用複方甘草痠苷併給予補鉀、補液治療10 d後,血鉀升至5.1 mmol/L,肌痠激酶降至450 U/L,肌痛、乏力消失.
1례37세남성인을형간염표면항원(HBsAg)、e항체(HBeAb)、핵심항체(HBcAb)양성화전안매승고복용복방감초산감25 mg,3차/d,공1개월.1개월후출현쌍하지산통、핍력,실험실검사시혈갑1.8 mmol/L,기산격매8 378 U/L,고필시복방감초산감소치저혈갑여횡문기용해.정용복방감초산감병급여보갑、보액치료10 d후,혈갑승지5.1 mmol/L,기산격매강지450 U/L,기통、핍력소실.
A 37-year-old male received compound glycyrrhizin 25 mg three times daily for one month because of positive HBsAg,HBeAb,HBcAb and increased serum aminotransferase.He developed ache in both lower extremities and fatigue.Laboratory tests revealed the following results:serum potassium 1.8 mmol/L,creatine kinase 8 378 U/L.The patient was considered to have compound glycyrrhizininduced hypokalemia and rhabdomyolysis.Compound glycyrrhizin was stopped and the patient was treated with potassium supplement and fluid infusion for 10 days.His serum potassium increased to 5.1 mmol/L,creatine kinase decreased to 450 U/L.His ache in both lower extremities and fatigue symptoms disappeared.
