中华眼外伤职业眼病杂志
中華眼外傷職業眼病雜誌
중화안외상직업안병잡지
CHINESE JOURNAL OF OCULAR TRAUMA AND OCCUPATIONAL EYE DISEASE
2013年
3期
209-212
,共4页
陆岩%陈晓隆%底煜%刘鹤南
陸巖%陳曉隆%底煜%劉鶴南
륙암%진효륭%저욱%류학남
角膜上皮损伤%角膜接触镜%角膜上皮修复
角膜上皮損傷%角膜接觸鏡%角膜上皮脩複
각막상피손상%각막접촉경%각막상피수복
Epithelium defect,corneal%Soft contact lense%Corneal epithelial healing
目的 探讨软性角膜接触镜对机械性角膜上皮损伤的治疗作用,评价其疗效.方法 将诊断为机械性角膜上皮损伤的240例(240眼)随机平分为试验组和对照组.试验组患眼连续配戴亲水性软性角膜接触镜(SCL)1周,对照组患眼用消毒眼垫包扎.之后所有患者常规用0.5％可乐必妥滴眼液和贝复舒滴眼液,4次/d,连续2周.术后随访2周,分别于治疗前及治疗后3d、7d、14 d依据患者主诉和裂隙灯显微镜观察角膜上皮修复程度对术后局部症状、体征进行客观评分,并记录角膜上皮愈合时间,进行统计学分析,评价疗效.结果 试验组与对照组症状体征综合评分于用药前差异无统计学意义(t=1.2856,P=0.2012).治疗后3天评分下降幅度试验组大于对照组,差异有统计学意义(t=3.4317,P=0.0146).试验组与对照组比较,治疗后3天治疗组有效率明显高于对照组,差异有统计学意义(x2 =6.026,P=0.0152).试验组角膜上皮愈合时间为(3.01±1.36)d,对照组为(4.08±1.59)d,试验组明显短于对照组,两组之间差异有统计学意义(t=4.5416,P=0.0105).结论 在机械性角膜上皮损伤治疗过程中,软性角膜接触镜与局部合理用药有助于促进伤口愈合,缩短疗程,减轻症状,减少并发症.
目的 探討軟性角膜接觸鏡對機械性角膜上皮損傷的治療作用,評價其療效.方法 將診斷為機械性角膜上皮損傷的240例(240眼)隨機平分為試驗組和對照組.試驗組患眼連續配戴親水性軟性角膜接觸鏡(SCL)1週,對照組患眼用消毒眼墊包扎.之後所有患者常規用0.5％可樂必妥滴眼液和貝複舒滴眼液,4次/d,連續2週.術後隨訪2週,分彆于治療前及治療後3d、7d、14 d依據患者主訴和裂隙燈顯微鏡觀察角膜上皮脩複程度對術後跼部癥狀、體徵進行客觀評分,併記錄角膜上皮愈閤時間,進行統計學分析,評價療效.結果 試驗組與對照組癥狀體徵綜閤評分于用藥前差異無統計學意義(t=1.2856,P=0.2012).治療後3天評分下降幅度試驗組大于對照組,差異有統計學意義(t=3.4317,P=0.0146).試驗組與對照組比較,治療後3天治療組有效率明顯高于對照組,差異有統計學意義(x2 =6.026,P=0.0152).試驗組角膜上皮愈閤時間為(3.01±1.36)d,對照組為(4.08±1.59)d,試驗組明顯短于對照組,兩組之間差異有統計學意義(t=4.5416,P=0.0105).結論 在機械性角膜上皮損傷治療過程中,軟性角膜接觸鏡與跼部閤理用藥有助于促進傷口愈閤,縮短療程,減輕癥狀,減少併髮癥.
목적 탐토연성각막접촉경대궤계성각막상피손상적치료작용,평개기료효.방법 장진단위궤계성각막상피손상적240례(240안)수궤평분위시험조화대조조.시험조환안련속배대친수성연성각막접촉경(SCL)1주,대조조환안용소독안점포찰.지후소유환자상규용0.5％가악필타적안액화패복서적안액,4차/d,련속2주.술후수방2주,분별우치료전급치료후3d、7d、14 d의거환자주소화렬극등현미경관찰각막상피수복정도대술후국부증상、체정진행객관평분,병기록각막상피유합시간,진행통계학분석,평개료효.결과 시험조여대조조증상체정종합평분우용약전차이무통계학의의(t=1.2856,P=0.2012).치료후3천평분하강폭도시험조대우대조조,차이유통계학의의(t=3.4317,P=0.0146).시험조여대조조비교,치료후3천치료조유효솔명현고우대조조,차이유통계학의의(x2 =6.026,P=0.0152).시험조각막상피유합시간위(3.01±1.36)d,대조조위(4.08±1.59)d,시험조명현단우대조조,량조지간차이유통계학의의(t=4.5416,P=0.0105).결론 재궤계성각막상피손상치료과정중,연성각막접촉경여국부합리용약유조우촉진상구유합,축단료정,감경증상,감소병발증.
Objective To evaluate the effect of soft contact lenses on healing of corneal epithelial mechanical trauma.Methods Two hundred fourty cases (240 eyes) of corneal epithelial mechanical trauma were randomly and equally divided into experimental group and control group.The experimental group was treated with extended wearing hydrophilic soft contact lens (SCL) for 1 week,the control group with sterile eye pad dressing.Then all the patients were treated conventionally with 0.5％ levofloxacin eye drops and recombinant bovine basic fibroblast growth factor(bFGF) eye drops for 2 weeks,four times a day.During the follow-up period of 2 weeks,local symptoms and signs were scored according to patients' complaints and slit lamp microscope observation before treatment and the 3rd day,the 7th day and the 14th day after treatment respectively.The time of corneal epithelial healing of two groups were recorded.The result were statistically analysed,and the efficacy of two treatments were evaluated.Results There was no significant difference in scores of local symptoms and signs between experimental and control group before treatment (t =1.2856,P =0.2012).The experimental group got a more significant decline of scores than control group on the 3rd day after treatment(t =3.4317,P =0.0146) ;In comparison with the control group,the effective rate of the experimental group was significantly higher at the 3 rd day after treatment (x2 =6.026,P =0.0152) ; The corneal epithelial healing time of the experimental group was (3.01 ± 1.36) d it was shorter than that of the control group,which was (4.08 ± 1.59)d.The difference between two groups was statistically significant(t=4.5416,P =0.0105).Conclusion During the healing of the corneal epithelial mechanical trauma,SCL with local medication can promote wound healing,shorten the course of treatment,reduce symptoms and decrease complications.
