中华眼外伤职业眼病杂志
中華眼外傷職業眼病雜誌
중화안외상직업안병잡지
CHINESE JOURNAL OF OCULAR TRAUMA AND OCCUPATIONAL EYE DISEASE
2013年
5期
321-325
,共5页
林世斌%李丹%李玲%林泽彪
林世斌%李丹%李玲%林澤彪
림세빈%리단%리령%림택표
白内障,老年性%滴眼液,抗生素%口咽部%细菌
白內障,老年性%滴眼液,抗生素%口嚥部%細菌
백내장,노년성%적안액,항생소%구인부%세균
Cataract,senile%Eyedrops,antibiotic%Oropharynx%Bacteria
目的 了解老年性白内障患者围手术期使用抗生素滴眼液前后口咽部细菌分布与耐药性的变化情况.方法 前瞻性观察研究老年性白内障手术110例(110眼),分别于用药前、用药(10±1)d与停药(23 ±3)d 3个时间点取咽拭子送检,对分离菌株做鉴定与药敏试验,结果作统计学分析.结果 手术前后共收集318份咽拭子标本,细菌培养阳性率为100％,共检测出15种细菌；检出率最高的4种菌为甲型链球菌、卡他奈瑟菌、表皮葡萄球菌与肺炎克雷伯菌；在用药(10±1)d与停药(23±3)d时,有部分菌群的检出率出现下降与回升的现象；甲型链球菌、表皮葡萄球菌对环丙沙星的耐药率在用药(10±1)d时出现上升.结论 抗生素滴眼液对口咽部细菌检出率存在一定影响并有可能改变细菌的耐药率.
目的 瞭解老年性白內障患者圍手術期使用抗生素滴眼液前後口嚥部細菌分佈與耐藥性的變化情況.方法 前瞻性觀察研究老年性白內障手術110例(110眼),分彆于用藥前、用藥(10±1)d與停藥(23 ±3)d 3箇時間點取嚥拭子送檢,對分離菌株做鑒定與藥敏試驗,結果作統計學分析.結果 手術前後共收集318份嚥拭子標本,細菌培養暘性率為100％,共檢測齣15種細菌；檢齣率最高的4種菌為甲型鏈毬菌、卡他奈瑟菌、錶皮葡萄毬菌與肺炎剋雷伯菌；在用藥(10±1)d與停藥(23±3)d時,有部分菌群的檢齣率齣現下降與迴升的現象；甲型鏈毬菌、錶皮葡萄毬菌對環丙沙星的耐藥率在用藥(10±1)d時齣現上升.結論 抗生素滴眼液對口嚥部細菌檢齣率存在一定影響併有可能改變細菌的耐藥率.
목적 료해노년성백내장환자위수술기사용항생소적안액전후구인부세균분포여내약성적변화정황.방법 전첨성관찰연구노년성백내장수술110례(110안),분별우용약전、용약(10±1)d여정약(23 ±3)d 3개시간점취인식자송검,대분리균주주감정여약민시험,결과작통계학분석.결과 수술전후공수집318빈인식자표본,세균배양양성솔위100％,공검측출15충세균；검출솔최고적4충균위갑형련구균、잡타내슬균、표피포도구균여폐염극뢰백균；재용약(10±1)d여정약(23±3)d시,유부분균군적검출솔출현하강여회승적현상；갑형련구균、표피포도구균대배병사성적내약솔재용약(10±1)d시출현상승.결론 항생소적안액대구인부세균검출솔존재일정영향병유가능개변세균적내약솔.
Objective To investigate the distribution and drug resistance of oropharyngeal flora in patients with senile cataract undergoing antibiotic eyedrops used for perioperative period.Methods Prospective and observational study design.Totally 110 cases(110 eyes) with senile cataract were enrolled in this study.An oropharyngeal swabs were taken from each patient at three time point:before medications,after application of antibiotic eye drops (10 ± 1) d and after stopping medication (23 ± 3) d.The bacterial culture,identification,distribution and drug resistance were statistical analyzed.Results Totally 318 throat swab samples were collected and 15 kinds of bacteria were isolated.The prevalence of oropharyngeal bacterial carriage was 100％.The top four bacteria were alpha hemolytic streptococcus,Moraxella catarrhalis,staphylococcus epidermidis and Klebsiella pneumoniae.There were some positive rates of bacteria showed an downward tendency at the second time-point and some showed an upward tendency at endpoint.The rates of resistance to Ciprofloxacin increased by alpha hemolytic streptococcus and staphylococcus epidermidis after application of antibiotic eye drops (10 ± 1) d.Conclusion The antibiotic eye drops may affect the detected rates and drug resistance of oropharyngeal bacteria.
