CAJ | 학술논문

目的观察补充叶黄素对长时间暴露于强光下的职业人群视功能的影响.方法选取40例从事电焊工作的正常人纳入研究,随机分为叶黄素干预组和安慰剂对照剂组.干预组每日口服叶黄素20 mg,持续12周.对照组服用安慰剂.检测视力、血清叶黄素含量、黄斑色素密度值、对比敏感度及眩光敏感度,分析补充叶黄素对长期曝光职业人群黄斑色素密度与视功能相关指标的影响.结果干预组矫正视力有升高趋势,差异无统计学意义(tV1=1.729,tV2=1.645,tV3=1.559,P＞0.05).干预组与对照组相比,血清叶黄素含量(t=2.649,P＜0.01)及中央黄斑色素密度(F=3.48,p=0.041)有明显升高,对比敏感度及眩光敏感度明显升高(tCS =2.684,tGS =2.815,P＜0.05).结论补充叶黄素对长时间光暴露职业人群黄斑色素密度及视功能有保护作用,尤其体现在对暗光照环境下对比敏感度及眩光敏感度的保护,可考虑作为职业保护的补充手段.
목적 관찰보충협황소대장시간폭로우강광하적직업인군시공능적영향.방법 선취40례종사전한공작적정상인납입연구,수궤분위협황소간예조화안위제대조제조.간예조매일구복협황소20 mg,지속12주.대조조복용안위제.검측시력、혈청협황소함량、황반색소밀도치、대비민감도급현광민감도,분석보충협황소대장기폭광직업인군황반색소밀도여시공능상관지표적영향.결과 간예조교정시력유승고추세,차이무통계학의의(tV1=1.729,tV2=1.645,tV3=1.559,P＞0.05).간예조여대조조상비,혈청협황소함량(t=2.649,P＜0.01)급중앙황반색소밀도(F=3.48,p=0.041)유명현승고,대비민감도급현광민감도명현승고(tCS =2.684,tGS =2.815,P＜0.05).결론 보충협황소대장시간광폭로직업인군황반색소밀도급시공능유보호작용,우기체현재대암광조배경하대비민감도급현광민감도적보호,가고필작위직업보호적보충수단.
Objective To examine the influence of lutein supplementation on visual performance in healthy occupational population with long-term light exposure.Methods The study was a randomized,placebo-controlled,12-week intervention study.40 normal subjects (welder) were recruited.The Active (A) group consumed 20 mg of lutein daily.Subjects were assessed at baseline,one,four,and twelve weeks (V0,V1,V2 and V3,respectively),including visual acuity,serum lutein concentrations,macular pigment optical density (MPOD) and visual performance.Results There was a trend (in the Active group) towards an increase in visual acuity,but there were no significant differences.Serum lutein and central MPOD in the Active group increased significantly,whereas no change was observed in the Placebo group.We observed significant increases in the contrast sensitivity and glare sensitivity,especially on mesopic condition in the Active group.Conclusion Daily supplementation with 20 mg of lutein increases MPOD levels and visual performance.Lutein may benefit the occupational population with long-term light exposure.