CAJ | 학술논문

目的探讨砷暴露对女性月经情况的影响.方法 2004年,采用整群抽样方法,对内蒙古巴彦淖尔市临河区、杭锦后旗和五原县5个乡10个社的所有10 ～ 65岁的女性,采集家中饮用水水样检测水砷,并按照水砷不同,调查对象分为对照组(≤0.01 mg/L)、低砷组(＞0.01～0.10 mg/L)、中砷组(＞0.10～0.20 mg/L)和高砷组(＞ 0.20 mg/L)进行月经相关情况调查.结果共计调查602名女性,其中月经初潮前有砷暴露者83人,其月经初潮年龄为(14.37±1.54)岁；停经前有砷暴露者90人,停经年龄为(48.13±0.41)岁.经过相关性分析,月经初潮年龄和停经年龄与砷暴露年限均呈正相关,相关系数分别为0.268、0.278(P均＜0.05).与对照组[14.0％(16/112)]比较,中砷组月经异常率[18.2％(16/88)]有所增加,低砷组[12.1％(21/173)]、高砷组[10.2％(19/186)]有所降低,但4组比较差异无统计学意义(x2=3.664,P＞ 0.05).结论长期砷暴露可以使女性月经的初潮年龄和停经年龄有所推迟,提示砷具有一定的内分泌干扰作用或雌激素样效应.
목적 탐토신폭로대녀성월경정황적영향.방법 2004년,채용정군추양방법,대내몽고파언뇨이시림하구、항금후기화오원현5개향10개사적소유10 ～ 65세적녀성,채집가중음용수수양검측수신,병안조수신불동,조사대상분위대조조(≤0.01 mg/L)、저신조(＞0.01～0.10 mg/L)、중신조(＞0.10～0.20 mg/L)화고신조(＞ 0.20 mg/L)진행월경상관정황조사.결과 공계조사602명녀성,기중월경초조전유신폭로자83인,기월경초조년령위(14.37±1.54)세；정경전유신폭로자90인,정경년령위(48.13±0.41)세.경과상관성분석,월경초조년령화정경년령여신폭로년한균정정상관,상관계수분별위0.268、0.278(P균＜0.05).여대조조[14.0％(16/112)]비교,중신조월경이상솔[18.2％(16/88)]유소증가,저신조[12.1％(21/173)]、고신조[10.2％(19/186)]유소강저,단4조비교차이무통계학의의(x2=3.664,P＞ 0.05).결론 장기신폭로가이사녀성월경적초조년령화정경년령유소추지,제시신구유일정적내분비간우작용혹자격소양효응.
Objective To study the influence of arsenic exposure on menstruation.Methods A cluster sampling method was applied to select the subjects of women aged 10 to 65 from Linhe,Hangjinhouqi and Wuyuan counties in Inner Mongolia in 2004.Drinking water samples were collected to detect arsenic levels,and menstrual related situation was surveyed.The subjects were divided into four groups according to drinking water arsenic concentration:control(≤0.01 mg/L),low(＞ 0.01-0.10 mg/L),moderate(＞ 0.10-0.20 mg/L) and high(＞ 0.20mag/L).Results A total of 602 women were surveyed.There were 83 subjects exposed to arsenic before menarche and their menarche age was (14.37 ± 1.54) years old.There were 90 people exposed to arsenic before menopause and the menopause age was (48.13-0.41) years old.The age of menarche and menopause were positively related to the years of arsenic exposure,and correlation coefficients were 0.268 and 0.278 (all P ＜ 0.05).Compared to control group(14.0％,16/112),menstrual abnormality rate decreased in low(12.1％,21/173) and high dose groups(10.2％,19/186),while increased in the moderate dose group(18.2％,16/88),but the differences were not statistically significant(x2 =3.664,P ＞ 0.05).Conclusions Long-term arsenic exposure delays the menarche and menopause age,suggesting that arsenic has certain endocrine disruption or estrogen-like effects.