CAJ | 학술논문

目的检查经综合治理后的燃煤污染型地方性氟中毒(地氟病)病区人群血脂改变(包括总胆固醇、甘油三酯和高密度脂蛋白),寻找经综合防治措施后病区人群病情好转的健康判别指标.方法 2011年,在贵州省毕节市选择燃煤污染型地氟病病区人群,按综合治理时间长短和病情轻重分为4个组,轻病区+治理短组(98例)、轻病区+治理长组(70例)、重病区+治理短组(61例)、重病区+治理长组(164例)；在贵阳市选择非地氟病病区人群(125例)作为对照组.两组人群空腹采血,采用酶联免疫吸附试验(ELISA)法测定血清中总胆固醇、甘油三酯和高密度脂蛋白含量.结果轻病区+治理短组、轻病区+治理长组、重病区+治理短组、重病区+治理长组人群血清总胆固醇水平[(5.75±3.16)、(5.56±2.86)、(7.25±3.84)、(6.51±3.48)mmolL]、甘油三酯水平[(256±1.45)、(2.98±1.50)、(3.20±1.65)、(2.94±1.49)mmol/L]均高于对照组[(3.97±1.80)、(1.25±0.97) mmol/L,P均＜0.05],而高密度脂蛋白水平[(0.72±0.40)、(0.96±0.60)、(0.46±0.27)、(0.81±0.43)mmol/L]明显低于对照组[(1.15±0.67) mmol/,P均＜0.05]；在综合治理时间较长的地氟病轻、重病区人群,仅高密度脂蛋白水平较综合治理时间较短的氟中毒轻、重病区人群明显改善(P均＜ 0.05).结论通过综合治理,地氟病病区人群血清中高密度脂蛋白的水平明显增高,其机制可能与综合治理后减弱氟对心血管的损伤有关,但对血清总胆固醇和甘油三酯水平无明显影响,人体血清中高密度脂蛋白水平可考虑为评估综合治理后病区人群血脂水平改善的指标.
목적 검사경종합치리후적연매오염형지방성불중독(지불병)병구인군혈지개변(포괄총담고순、감유삼지화고밀도지단백),심조경종합방치조시후병구인군병정호전적건강판별지표.방법 2011년,재귀주성필절시선택연매오염형지불병병구인군,안종합치리시간장단화병정경중분위4개조,경병구+치리단조(98례)、경병구+치리장조(70례)、중병구+치리단조(61례)、중병구+치리장조(164례)；재귀양시선택비지불병병구인군(125례)작위대조조.량조인군공복채혈,채용매련면역흡부시험(ELISA)법측정혈청중총담고순、감유삼지화고밀도지단백함량.결과 경병구+치리단조、경병구+치리장조、중병구+치리단조、중병구+치리장조인군혈청총담고순수평[(5.75±3.16)、(5.56±2.86)、(7.25±3.84)、(6.51±3.48)mmolL]、감유삼지수평[(256±1.45)、(2.98±1.50)、(3.20±1.65)、(2.94±1.49)mmol/L]균고우대조조[(3.97±1.80)、(1.25±0.97) mmol/L,P균＜0.05],이고밀도지단백수평[(0.72±0.40)、(0.96±0.60)、(0.46±0.27)、(0.81±0.43)mmol/L]명현저우대조조[(1.15±0.67) mmol/,P균＜0.05]；재종합치리시간교장적지불병경、중병구인군,부고밀도지단백수평교종합치리시간교단적불중독경、중병구인군명현개선(P균＜ 0.05).결론 통과종합치리,지불병병구인군혈청중고밀도지단백적수평명현증고,기궤제가능여종합치리후감약불대심혈관적손상유관,단대혈청총담고순화감유삼지수평무명현영향,인체혈청중고밀도지단백수평가고필위평고종합치리후병구인군혈지수평개선적지표.
Objective To detect the level of serum high-density lipoprotein,total cholesterol and triglycerides in coal-burning-borne endemic fluorosis areas in Guizhou and to look for health improvement index after implementation of comprehensive control measures.Methods People in coal-burning-borne endemic fluorosis areas in Bijie city of Guizhou were selected and divided into four groups according to the duration of comprehensive treatments and the severity of fluorosis:moderate illness district + short treatment group(98 cases),moderate illness district + long treatment group(70 cases),serious illness district + short treatment group(61 cases),serious illness district + long treatment group (164 cases) ; in addition,the people in Guiyang were selected as non-fluorosis controls in 2011.Fasting blood samples were collected for detection of serum high-density lipoprotein,total cholesterol and triglycerides using enzyme linked immunosorbent assay (ELISA) method.Results As compared to controls [(3.97 ± 1.80),(1.25 ± 0.97),(1.15 ± 0.67) mmol/L],the levels of total cholesterol[(5.75 ± 3.16),(5.56 ± 2.86),(7.25 ± 3.84),(6.51 ± 3.48)mmol/L] and triglycerides[(2.56 ± 1.45),(2.98 ± 1.50),(3.20 ±1.65),(294 ± 1.49)mmol/L] were significantly increased(all P ＜ 0.05),whereas the amount of high-density lipoprotein [(0.72 ± 0.40),(0.96 ± 0.60),(0.46 ± 0.27),(0.81 ± 0.43)mmol/L] were significantly declined(all P ＜ 0.05)in all fluorosis groups.In these two fluorosis groups with long period of comprehensive treatment,only the declined high-density lipoprotein was not so lower than those in the fluorosis groups with short period of treatment(all P ＜ 0.05).Conclusions Certain period of comprehensive prevention treatment can obviously increase the declined contents of high-density lipoprotein in serum of population living in coal-burning-borne endemic fluorosis areas,and the mechanism might be weakened damage of fluorosis to cardiovascular system.The contents of total cholesterol and triglycerides are not significantly changed.The content of high-density lipoprotein may be considered as an indicator for assessment of comprehensive treatment in coal-burning-borne endemic fluorosis areas.