中华地方病学杂志
中華地方病學雜誌
중화지방병학잡지
Chinese Journal of Endemiology
2014年
3期
335-338
,共4页
苏丽琴%程义斌%梁超轲%马凤%陈晨%刘静怡%李平%金银龙
囌麗琴%程義斌%樑超軻%馬鳳%陳晨%劉靜怡%李平%金銀龍
소려금%정의빈%량초가%마봉%진신%류정이%리평%금은룡
硒%环境暴露%血压%老年人群
硒%環境暴露%血壓%老年人群
서%배경폭로%혈압%노년인군
Selenium%Environmental exposure%Blood pressure%Elderly population
目的 探讨环境低硒与我国农村老年人群血压的相关性.方法 从环境低硒地区和适宜硒地区分别抽取≥65周岁的农村老年人群各500名,开展流行病学调查和人体学测量(包括血压测量);收集手指甲样品,采用2,3-二氨基萘荧光法检测硒含量.结果 低硒地区人群指甲硒含量为(0.211±0.057)μg/g,适宜硒地区人群指甲硒含量为(0.434±0.136)μg/g,二者比较,差异有统计学意义(t=33.87,P＜0.05).调整性别、年龄、吸烟、饮酒、体质指数(BMI)、教育程度后,总人群指甲硒含量与收缩压和舒张压均呈显著正相关(r值分别为0.231、0.188,P均＜0.05),但低硒地区人群和适宜硒地区人群分别独立分析均未发现明显相关性(P均＞0.05).适宜硒地区人群高血压检出率(68.4％,342/500)显著高于低硒地区人群(41.2％,206/500),二者比较,差异有统计学意义(x2=74.67,P＜0.05).按照指甲硒水平五分位数将观察对象划分成5组后,未发现5组间高血压检出率的差异有统计学意义(P均＞ 0.05).结论 环境低硒暴露可能与老年人血压存在关联,但尚需大规模纵向人群研究来进行论证.
目的 探討環境低硒與我國農村老年人群血壓的相關性.方法 從環境低硒地區和適宜硒地區分彆抽取≥65週歲的農村老年人群各500名,開展流行病學調查和人體學測量(包括血壓測量);收集手指甲樣品,採用2,3-二氨基萘熒光法檢測硒含量.結果 低硒地區人群指甲硒含量為(0.211±0.057)μg/g,適宜硒地區人群指甲硒含量為(0.434±0.136)μg/g,二者比較,差異有統計學意義(t=33.87,P＜0.05).調整性彆、年齡、吸煙、飲酒、體質指數(BMI)、教育程度後,總人群指甲硒含量與收縮壓和舒張壓均呈顯著正相關(r值分彆為0.231、0.188,P均＜0.05),但低硒地區人群和適宜硒地區人群分彆獨立分析均未髮現明顯相關性(P均＞0.05).適宜硒地區人群高血壓檢齣率(68.4％,342/500)顯著高于低硒地區人群(41.2％,206/500),二者比較,差異有統計學意義(x2=74.67,P＜0.05).按照指甲硒水平五分位數將觀察對象劃分成5組後,未髮現5組間高血壓檢齣率的差異有統計學意義(P均＞ 0.05).結論 環境低硒暴露可能與老年人血壓存在關聯,但尚需大規模縱嚮人群研究來進行論證.
목적 탐토배경저서여아국농촌노년인군혈압적상관성.방법 종배경저서지구화괄의서지구분별추취≥65주세적농촌노년인군각500명,개전류행병학조사화인체학측량(포괄혈압측량);수집수지갑양품,채용2,3-이안기내형광법검측서함량.결과 저서지구인군지갑서함량위(0.211±0.057)μg/g,괄의서지구인군지갑서함량위(0.434±0.136)μg/g,이자비교,차이유통계학의의(t=33.87,P＜0.05).조정성별、년령、흡연、음주、체질지수(BMI)、교육정도후,총인군지갑서함량여수축압화서장압균정현저정상관(r치분별위0.231、0.188,P균＜0.05),단저서지구인군화괄의서지구인군분별독립분석균미발현명현상관성(P균＞0.05).괄의서지구인군고혈압검출솔(68.4％,342/500)현저고우저서지구인군(41.2％,206/500),이자비교,차이유통계학의의(x2=74.67,P＜0.05).안조지갑서수평오분위수장관찰대상화분성5조후,미발현5조간고혈압검출솔적차이유통계학의의(P균＞ 0.05).결론 배경저서폭로가능여노년인혈압존재관련,단상수대규모종향인군연구래진행론증.
Objective To preliminarily explore the relationship between environmental low selenium exposure and blood pressure in rural elderly Chinese.Methods Respectively 500 subjects aged 65 or older were recruited from environmental low and optimal selenium rural areas.Questionnaire survey and physical measurement including blood pressure,were carried out.Finger nail samples were collected and the trace amount of selenium was detected with 2,3-diaminonaphthalenet fluorometric determination method.Results Finger nail selenium level [(0.211 ± 0.057)μg/g] of subjects in low selenium areas was significantly lower than that[(0.431 ± 0.136) μg/g] of subjects in optimal selenium areas (t =33.87,P ＜ 0.05).Systolic blood pressure (SBP) and diastolic blood pressure(DBP) were positively associated with finger nail selenium levels in overall population(rSBP =0.231,rDBP=0.188,all P ＜ 0.05),but no such association was observed in population of optimal selenium areas or low selenium areas.The detection rate of hypertension [68.4％ (342/500)] in optimal selenium areas was significantly higher than that[41.2％(206/500)] of low selenium areas(x2 =74.672,P ＜ 0.05),but no significant difference was observed among 5 groups of subjects in different selenium quintiles(all P ＞ 0.05).Conclusions Low environmental selenium exposure may be associated with blood pressure in elderly population.Large-scale and longitudinal population studies are needed to verify the possible association.
