CAJ | 학술논문

目的探讨血、尿β_2-微球蛋白(β_2-mG)检测对顺铂化疗时肾毒性早期诊断的临床意义.方法动态监测64例共接受HD-DDP(80～110 mg/m~2)化疗86周期患者的血、尿β_2-mG及血清尿素氮(BUN)、肌酐(Cr)水平变化.结果化疗后前3 d(d_(1～3))血、尿β_2-mG值逐渐升高,第5天开始逐渐下降,其中以尿β_2-mG异常为主(P＜0.01),血清BUN、Cr异常在化疗后第5、7、14天明显升高,晚于血、尿β_2-mG异常改变.结论血、尿β_2-mG尤其是后者,对顺铂肾毒性的早期诊断十分敏感且简便,具有重要的临床推广价值.
목적 탐토혈、뇨β_2-미구단백(β_2-mG)검측대순박화료시신독성조기진단적림상의의.방법 동태감측64례공접수HD-DDP(80～110 mg/m~2)화료86주기환자적혈、뇨β_2-mG급혈청뇨소담(BUN)、기항(Cr)수평변화.결과 화료후전3 d(d_(1～3))혈、뇨β_2-mG치축점승고,제5천개시축점하강,기중이뇨β_2-mG이상위주(P＜0.01),혈청BUN、Cr이상재화료후제5、7、14천명현승고,만우혈、뇨β_2-mG이상개변.결론 혈、뇨β_2-mG우기시후자,대순박신독성적조기진단십분민감차간편,구유중요적림상추엄개치.
Objective To explore the early diagnosis value of serum and urine β_2-microglobulin(β_2-MG) in HD-DDP nephrotoxicity.Methods The level changes of serumβ_2-MG,BUN,Cr and urine β_2-MG were measured dynami-cally in 64 cases receiving high-dose DDP(80-110 mg/m~2) chemotherapy during 86 cycles.Results In the early stage of chemotherapy(d_(1～3)),the level of serum and urine β_2-mG increased gradually,and lowered gradully from the fifth day.The level changes of urine β_2-mG was significantly higher than that of serum β_2-mG(P ＜0.01).The level of serum BUN and Cr increased ingnificantly in the cases of late period of chemotherapy(d 5,d 7,d 14).Conclusion The measurement of serum and urine β_2-MG,especially the latter,has an important clinical value for early diagnosis of DDP nephrotoxicity.