CAJ | 학술논문

目的观察西格列汀联合参麦注射液治疗2型糖尿病的临床疗效.方法选择2型糖尿病患者60例,随机分为治疗组和对照组,治疗组给予磷酸西格列汀片+参麦注射液,对照组予阿卡波糖,两组均治疗14周.检测治疗前后空腹血糖(FBG)及餐后2h血糖(2hBG)、糖化血红蛋白(HbA1c)、血脂(TC、TG、LDL-C、HDL-C)、体质量指数(BMI)、低血糖发生率、血液流变学、经颅多普勒超声(TCD)、肝肾功能及尿蛋白.结果治疗后两组FBG、2hBG、HbA1c、TC、TG、LDL-C、HDL-C水平与治疗前差异均有统计学意义(P＜0.05或P＜0.01),但治疗组对血脂的控制更优于对照组;治疗组在减少低血糖和体质量增加的风险方面优于对照组(P＜0.05);治疗组全血黏度、血浆黏度、低切黏度和红细胞比容治疗后较治疗前有明显降低(P＜0.05),而对照组无明显改变;TCD颅内血管血流速度异常数治疗前后相比,治疗组异常率为52.6％,明显优于对照组的86.5％(P＜0.05).结论西格列汀与参麦注射液联合治疗2型糖尿病效果显著,相对于传统降糖药,该组合具有有效降糖控脂,较少不良反应等优势.
목적 관찰서격렬정연합삼맥주사액치료2형당뇨병적림상료효.방법 선택2형당뇨병환자60례,수궤분위치료조화대조조,치료조급여린산서격렬정편+삼맥주사액,대조조여아잡파당,량조균치료14주.검측치료전후공복혈당(FBG)급찬후2h혈당(2hBG)、당화혈홍단백(HbA1c)、혈지(TC、TG、LDL-C、HDL-C)、체질량지수(BMI)、저혈당발생솔、혈액류변학、경로다보륵초성(TCD)、간신공능급뇨단백.결과 치료후량조FBG、2hBG、HbA1c、TC、TG、LDL-C、HDL-C수평여치료전차이균유통계학의의(P＜0.05혹P＜0.01),단치료조대혈지적공제경우우대조조;치료조재감소저혈당화체질량증가적풍험방면우우대조조(P＜0.05);치료조전혈점도、혈장점도、저절점도화홍세포비용치료후교치료전유명현강저(P＜0.05),이대조조무명현개변;TCD로내혈관혈류속도이상수치료전후상비,치료조이상솔위52.6％,명현우우대조조적86.5％(P＜0.05).결론 서격렬정여삼맥주사액연합치료2형당뇨병효과현저,상대우전통강당약,해조합구유유효강당공지,교소불량반응등우세.
Objective To observe the effect of Sitagliptin Phosphate Tablets combined with shenmai on type 2 diabetes.Methods Sixty diabetes patients were divided into two groups randomly:treatment group were received Sitagliptin Phosphate Tablets and shenmai;the control group were given acarbose.14 weeks later,the indications FBG,2HBG,HbA1 C,TC,TG,LDL-C,HDL-C,hypoglycemia happen rate,BMI,blood rheology,transcranial Doppler ultrasound(TCD)were tested to see if there is any change.Results After treatment,two groups of FBG,2hBG,HbA1 C,TC,TG,LDL-C,HDL-C levels compared with those before treatment were statistically significant(P＜0.05 or P＜0.01),but the treatment group on lipid control more than those in the control group;treatment group therapy in reducing the risk of hypoglycaemia and weight gain than the control group(P＜0.05);the whole blood viscosity,plasma viscosity,low viscosity and hematocrit of treatment group were significantly lower(P＜0.05),while the control group showed no significant change;the abnormal rate of treatment group was 52.6％,significantly better than the control group 86.5％(P＜0.05).Conclusion The effect of Sitagliptin Phosphate Tablets combined with shenmai on type 2 diabetes was significant,compared with the traditional antidiabetic drugs,the combination is effective hypoglycemic control fat and less adverse reactions.