中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
1期
34-36
,共3页
匹维溴铵%益生菌%腹泻%肠易激综合征
匹維溴銨%益生菌%腹瀉%腸易激綜閤徵
필유추안%익생균%복사%장역격종합정
Pinaverium bromide%Probiotics%Diarrhea%Irritable bowel syndrome
目的 分析匹维溴铵联合益生菌治疗肠易激综合征的临床疗效.方法 156例腹泻型肠易激综合征患者数字表法随机分为观察组和对照组,对照组口服匹维溴铵片,观察组在服用匹维溴铵的基础上,口服双歧三联活菌制剂,两组疗程均为4周.治疗结束后评价两组的临床疗效.结果 观察组和对照组总有效率分别为85.9％和70.5％,观察组临床疗效显著优于对照组(x2=8.557,P＜0.05)；治疗后观察组肛门直肠收缩压较对照组显著降低(t=4.432,P＜0.01),而静息压和舒张压差异无统计学意义(t=0.812、0.142,均P＞0.05)；治疗后观察组的初始感觉阈值、排便阈值和疼痛阈值均显著高于对照组(=3.440、4.671、3.697,均P＜0.01).结论 匹维溴铵联合益生菌治疗肠易激综合征的临床疗效显著,显著改善患者的肛门直肠动力和内脏敏感性.
目的 分析匹維溴銨聯閤益生菌治療腸易激綜閤徵的臨床療效.方法 156例腹瀉型腸易激綜閤徵患者數字錶法隨機分為觀察組和對照組,對照組口服匹維溴銨片,觀察組在服用匹維溴銨的基礎上,口服雙歧三聯活菌製劑,兩組療程均為4週.治療結束後評價兩組的臨床療效.結果 觀察組和對照組總有效率分彆為85.9％和70.5％,觀察組臨床療效顯著優于對照組(x2=8.557,P＜0.05)；治療後觀察組肛門直腸收縮壓較對照組顯著降低(t=4.432,P＜0.01),而靜息壓和舒張壓差異無統計學意義(t=0.812、0.142,均P＞0.05)；治療後觀察組的初始感覺閾值、排便閾值和疼痛閾值均顯著高于對照組(=3.440、4.671、3.697,均P＜0.01).結論 匹維溴銨聯閤益生菌治療腸易激綜閤徵的臨床療效顯著,顯著改善患者的肛門直腸動力和內髒敏感性.
목적 분석필유추안연합익생균치료장역격종합정적림상료효.방법 156례복사형장역격종합정환자수자표법수궤분위관찰조화대조조,대조조구복필유추안편,관찰조재복용필유추안적기출상,구복쌍기삼련활균제제,량조료정균위4주.치료결속후평개량조적림상료효.결과 관찰조화대조조총유효솔분별위85.9％화70.5％,관찰조림상료효현저우우대조조(x2=8.557,P＜0.05)；치료후관찰조항문직장수축압교대조조현저강저(t=4.432,P＜0.01),이정식압화서장압차이무통계학의의(t=0.812、0.142,균P＞0.05)；치료후관찰조적초시감각역치、배편역치화동통역치균현저고우대조조(=3.440、4.671、3.697,균P＜0.01).결론 필유추안연합익생균치료장역격종합정적림상료효현저,현저개선환자적항문직장동력화내장민감성.
Objective To investigate clinical effect of pinaverium bromide combined with probiotics in the treatment of patients with irritable bowel syndrome (IBS).Methods 156 patients with IBS were randomly divided into observation group and control group.Cases in control group received pinaverium bromide tablets,and cases in observation group received bifid triple viable capsule plus pinaverium bromide tablets.Duration of treatment was 4 weeks in both groups.Clinical efficacy was evaluated after treatment.Results Total effective rates of observation group and control group were respectively 85.9％ and 70.5％.Total effective rate of observation group was significantly better than that of control group(x2 =8.557,P ＜ 0.05).The systolic pressure of anorectum was significantly lower than that of control group after treatment(t =4.432,P ＜ 0.01),but resting pressure and diastolic pressure were not significantly different after treatment(t =0.812,0.142,all P ＞ 0.05).First sensation volume,defecating sensation volume and pain volume in observation group were significantly lower than those in control group (t =3.440,4.671,3.697,all P ＜ 0.01).Conclusion Treatment of IBS with pinaverium bromide combined with probiotics is effective,and it can improve the anorectal dynamic and isceral sensitivity in patients with IBS.
