中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
1期
49-51
,共3页
脑梗塞%C反应蛋白质%淀粉样蛋白A%法舒地尔
腦梗塞%C反應蛋白質%澱粉樣蛋白A%法舒地爾
뇌경새%C반응단백질%정분양단백A%법서지이
Brain infarction%C-Reactive protein%Amyloid protein A%Fasudil
目的 探讨法舒地尔对急性脑梗死患者血清超敏C反应蛋白(hs-CRP)和淀粉样蛋白A(SAA)的影响.方法 100例急性脑梗死患者数字表法随机分为两组,对照组50例,治疗组50例,对照组采用丹参注射液治疗,治疗组采用法舒地尔治疗,两组共治疗14 d.治疗前后测定患者血清hs-CRP和SAA.结果 治疗组总有效率为92％,对照组总有效率为84％,两组差异有统计学意义(x2=1.5152,P＜0.05).治疗组治疗前后hs-CRP分别为(11.3±3.7) mg/L、(3.6±1.1)mg/L,对照组治疗前后hs-CRP分别为(10.9 ±3.5) mg/L、(7.2 ±2.8) mg/L,两组治疗前后差异均有统计学意义(t=14.1053、5.8371,均P＜0.01)；两组治疗后差异有统计学意义(t =8.4618,P＜0.05).治疗组治疗前后SAA分别为(17.6±5.2) mg/L、(2.7±0.9)mg/L,对照组治疗前后SAA分别为(17.1±4.9)mg/L、(5.2±1.8) mg/L,两组治疗前后差异均有统计学意义(t=2.0096、2.0096,均P＜0.01)；两组治疗后差异有统计学意义(=8.7841,P＜0.05).结论 法舒地尔通过减轻炎性反应而缓解急性脑梗死患者的病情.
目的 探討法舒地爾對急性腦梗死患者血清超敏C反應蛋白(hs-CRP)和澱粉樣蛋白A(SAA)的影響.方法 100例急性腦梗死患者數字錶法隨機分為兩組,對照組50例,治療組50例,對照組採用丹參註射液治療,治療組採用法舒地爾治療,兩組共治療14 d.治療前後測定患者血清hs-CRP和SAA.結果 治療組總有效率為92％,對照組總有效率為84％,兩組差異有統計學意義(x2=1.5152,P＜0.05).治療組治療前後hs-CRP分彆為(11.3±3.7) mg/L、(3.6±1.1)mg/L,對照組治療前後hs-CRP分彆為(10.9 ±3.5) mg/L、(7.2 ±2.8) mg/L,兩組治療前後差異均有統計學意義(t=14.1053、5.8371,均P＜0.01)；兩組治療後差異有統計學意義(t =8.4618,P＜0.05).治療組治療前後SAA分彆為(17.6±5.2) mg/L、(2.7±0.9)mg/L,對照組治療前後SAA分彆為(17.1±4.9)mg/L、(5.2±1.8) mg/L,兩組治療前後差異均有統計學意義(t=2.0096、2.0096,均P＜0.01)；兩組治療後差異有統計學意義(=8.7841,P＜0.05).結論 法舒地爾通過減輕炎性反應而緩解急性腦梗死患者的病情.
목적 탐토법서지이대급성뇌경사환자혈청초민C반응단백(hs-CRP)화정분양단백A(SAA)적영향.방법 100례급성뇌경사환자수자표법수궤분위량조,대조조50례,치료조50례,대조조채용단삼주사액치료,치료조채용법서지이치료,량조공치료14 d.치료전후측정환자혈청hs-CRP화SAA.결과 치료조총유효솔위92％,대조조총유효솔위84％,량조차이유통계학의의(x2=1.5152,P＜0.05).치료조치료전후hs-CRP분별위(11.3±3.7) mg/L、(3.6±1.1)mg/L,대조조치료전후hs-CRP분별위(10.9 ±3.5) mg/L、(7.2 ±2.8) mg/L,량조치료전후차이균유통계학의의(t=14.1053、5.8371,균P＜0.01)；량조치료후차이유통계학의의(t =8.4618,P＜0.05).치료조치료전후SAA분별위(17.6±5.2) mg/L、(2.7±0.9)mg/L,대조조치료전후SAA분별위(17.1±4.9)mg/L、(5.2±1.8) mg/L,량조치료전후차이균유통계학의의(t=2.0096、2.0096,균P＜0.01)；량조치료후차이유통계학의의(=8.7841,P＜0.05).결론 법서지이통과감경염성반응이완해급성뇌경사환자적병정.
Objective To study the effectiveness of fasudil on the serum high sensitive C-reactive protein (hs-CRP) and serum amyloid A (SAA) in the patients with acute cerebral infarction.Methods 100 patients with acute cerebral infarction were randomly divided into two groups,the control group (n =50 cases) and the treatment group(n =50 cases).The patients in the control group were treated through salvia injection,while the patients in the treatment group were treated through fasudil.They were treated for forteen days.The hs-CRP and SAA in the serum were detected before and after treatment.Results The total efficienties were 92％ in the treatment group and 84％ in the control group.There was a significant difference between two groups(x2 =1.5152,P ＜ 0.05).The treatment group before and after treament with hs-CRP were (11.3 ± 3.7) mg/L,(3.6 ± 1.1) mg/L.The control group before and after treatment with hs-CRP were (10.9 ± 3.5) mg/L,(7.2 ± 2.8) mg/L.Before and after treatment two groups had significant difference (t =14.1053,P ＜ 0.01) ; after the treatment in the two groups had significant diffecence (t =8.4618,P ＜ 0.05).The treatment group before and after treatment with SAA were (17.6 ± 5.2) mg/L,(2.7 ± 0.9)mg/L,control group before and after SAA treatment were (17.1 ± 4.9) mg/L,(5.2 ± 1.8) mg/L.Before and after treatment,two groups had significant difference (t =2.0096,2.0096,all P ＜ 0.01) ; after the treatment in the two groups had significant difference(t =8.7841,P ＜ 0.05).Conclusion Fasudil can improve acute cerebral infarction throughmitigating inflammation.
