CAJ | 학술논문

目的研究慢性肾功能衰竭(CRF)患者血清总同型半胱氨酸(tHcy)浓度的变化,探讨血清tHcy浓度对CRF患者诊断及病情评估的价值.方法采用循环酶法测定105例CRF患者和35例对照组血清tHcy浓度.结果肾功能失代偿期患者的血清tHcy浓度显著高于对照组(t=3.12,P＜0.05).肾功能衰竭期患者显著高于肾功能失代偿期患者(t=6.41,P＜0.05),尿毒症期患者显著高于肾功能衰竭期患者(t=11.27,P＜0.05).结论血清tHcy浓度在CRF患者中明显升高,并且血清tHcy浓度随着病情的加重而呈逐渐上升的趋势,检测血清tHcy浓度对CRF患者的诊断及了解CRF患者的病情具有重要价值.
목적 연구만성신공능쇠갈(CRF)환자혈청총동형반광안산(tHcy)농도적변화,탐토혈청tHcy농도대CRF환자진단급병정평고적개치.방법 채용순배매법측정105례CRF환자화35례대조조혈청tHcy농도.결과 신공능실대상기환자적혈청tHcy농도현저고우대조조(t=3.12,P＜0.05).신공능쇠갈기환자현저고우신공능실대상기환자(t=6.41,P＜0.05),뇨독증기환자현저고우신공능쇠갈기환자(t=11.27,P＜0.05).결론 혈청tHcy농도재CRF환자중명현승고,병차혈청tHcy농도수착병정적가중이정축점상승적추세,검측혈청tHcy농도대CRF환자적진단급료해CRF환자적병정구유중요개치.
Objective To study the concentration of plasma total homocysteine(tHcy) in patients with chronic renal failure(CRF).Methods 105 chronic renal failure patients and 35 health individuals to our hospital were chosen to measure the level of tHcy using enzymatic cycling assay method.Results The mean level of tHcy in renal failure period C RF patients was significantly higher than that in normal controls (t =3.12,P ＜ 0.05),and the level of plasma tHcy was significantly higher in Uremia stage than in renal failure period in CRF patients (t =6.41,P ＜0.05),and the level of plasma tHcy was significantly higher in renal failure period than in renal function decompensated period in CRF patients (t =11.27,P ＜ 0.05).Conclusion The level of plasma tHcy were significantly elevated in patients with CRF,and there is a trend that the level of plasma tHcy increases with severity of CRF.Serum tHcy concentration have significant value in the diagnosis and understanding the condition of patients with CRF.