CAJ | 학술논문

目的探讨降钙素原(PCT)在重型颅脑损伤患者医院感染早期诊断中的临床应用价值.方法纳入因重型颅脑损伤人住ICU患者58例,在入住ICU时及人住第3天时检测PCT、C反应蛋白水平及白细胞计数,监测医院感染发生情况.结果两组入住ICU时血清PCT水平差异无统计学意义(P＞0.05),入住ICU第3天时感染组血清PCT水平明显升高,与非感染组差异有统计学意义(t=5.44,P＜0.01)；两组间C反应蛋白、白细胞计数在入住ICU时及入住ICU第3天时差异均无统计学意义(均P＞0.05).结论降钙素原测定有助于早期诊断急性颅脑疾病患者医院感染,早期合理选用抗生素,减少细菌耐药性的发生,可降低病死率.
목적 탐토강개소원(PCT)재중형로뇌손상환자의원감염조기진단중적림상응용개치.방법 납입인중형로뇌손상인주ICU환자58례,재입주ICU시급인주제3천시검측PCT、C반응단백수평급백세포계수,감측의원감염발생정황.결과 량조입주ICU시혈청PCT수평차이무통계학의의(P＞0.05),입주ICU제3천시감염조혈청PCT수평명현승고,여비감염조차이유통계학의의(t=5.44,P＜0.01)；량조간C반응단백、백세포계수재입주ICU시급입주ICU제3천시차이균무통계학의의(균P＞0.05).결론 강개소원측정유조우조기진단급성로뇌질병환자의원감염,조기합리선용항생소,감소세균내약성적발생,가강저병사솔.
Objective To investigate clinical value of serum procalcition(PCT) in early diagnosis of nosocomial infection in severe cerebral injury.Methods 58 patients with severe cerebral injury needing ICU monitoring were enrolled.Levels of serum PCT and C-reactive protein(CRP) and white blood cell(WBC) and nosocomial infection when entering ICU or on days 3 were observed.Results There were not difference in level Serum PCT when entering ICU in infection group compared with non-infection group(P ＞ 0.05).Serum PCT increeassd remarkably when entering ICU on days 3 in infection group as compared with non-infection group,the difference was significant (t =5.44,P ＜ 0.01).There were not difference in CRP and WBC level when entering ICU or on days 3 (all P ＞ 0.05).Conclusion Detection of serum PCT helps diagnosis early nosocomial infection in patients with severe cerebral injury.It is suggested that antibiotics should be chosen early in patients with obviously increased PCT,control abuse of antibiotics contributes to reduce incidence of drug resistance and mortality.