中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
3期
375-377
,共3页
子宫内膜异位症%腹腔镜检查%戈舍瑞林%米非司酮
子宮內膜異位癥%腹腔鏡檢查%戈捨瑞林%米非司酮
자궁내막이위증%복강경검사%과사서림%미비사동
Endometriosis%Laparoscopy%Goserelin%Mifepristone
目的 探讨中重度子宫内膜异位症腹腔镜保守性手术治疗后应用戈舍瑞林、米非司酮治疗的临床疗效及不良反应.方法 选择经腹腔镜保守手术后确诊的中重度子宫内膜异位症患者68例,随机区组法分为戈舍瑞林组34例、米非司酮组34例,疗程6个月,定期随访.比较两组临床疗效及不良反应.结果 两组患者痛经症状均得到不同程度缓解,有效率均91％以上,复发率米非司酮组高于戈舍瑞林组(14.71％与2.94％,P＜0.05),停药1年内累计妊娠率米非司酮组低于戈舍瑞林组(20.59％与38.23％,P＜0.05)；戈舍瑞林组肝功能损害发生率低于米非司酮组(2.94％与23.53％,P＜0.05).结论 中重度子宫内膜异位症腹腔镜保守性手术治疗后加用抑制卵巢功能药物对提高妊娠率、降低复发率有重要意义.
目的 探討中重度子宮內膜異位癥腹腔鏡保守性手術治療後應用戈捨瑞林、米非司酮治療的臨床療效及不良反應.方法 選擇經腹腔鏡保守手術後確診的中重度子宮內膜異位癥患者68例,隨機區組法分為戈捨瑞林組34例、米非司酮組34例,療程6箇月,定期隨訪.比較兩組臨床療效及不良反應.結果 兩組患者痛經癥狀均得到不同程度緩解,有效率均91％以上,複髮率米非司酮組高于戈捨瑞林組(14.71％與2.94％,P＜0.05),停藥1年內纍計妊娠率米非司酮組低于戈捨瑞林組(20.59％與38.23％,P＜0.05)；戈捨瑞林組肝功能損害髮生率低于米非司酮組(2.94％與23.53％,P＜0.05).結論 中重度子宮內膜異位癥腹腔鏡保守性手術治療後加用抑製卵巢功能藥物對提高妊娠率、降低複髮率有重要意義.
목적 탐토중중도자궁내막이위증복강경보수성수술치료후응용과사서림、미비사동치료적림상료효급불량반응.방법 선택경복강경보수수술후학진적중중도자궁내막이위증환자68례,수궤구조법분위과사서림조34례、미비사동조34례,료정6개월,정기수방.비교량조림상료효급불량반응.결과 량조환자통경증상균득도불동정도완해,유효솔균91％이상,복발솔미비사동조고우과사서림조(14.71％여2.94％,P＜0.05),정약1년내루계임신솔미비사동조저우과사서림조(20.59％여38.23％,P＜0.05)；과사서림조간공능손해발생솔저우미비사동조(2.94％여23.53％,P＜0.05).결론 중중도자궁내막이위증복강경보수성수술치료후가용억제란소공능약물대제고임신솔、강저복발솔유중요의의.
Objective To investigate the effect and severe adverse reactions of goserelin combined with mifepristone after operation for moderate and endometriosis laparoscopic conservative.Methods 68 cases with moderate to severe endometriosis diagnosed after laparoscopic conservative operation were randomly divided into the Gore Sherry Lin group and mifepristone group with 34 cases for 6 months of a course,regular follow-up.Clinical efficacy and adverse reaction for two groups were compared.Results The dysmenorrhea symptoms for two groups of patients have been alleviated,the efficiency rate was above 91％.The recurrence rate of the mifepristone group was higher than the goserelin group (14.71％ vs 2.94％,P ＜ 0.05).The cumulative pregnancy rate of mifepristone group was lower than the goserelin group (20.59％ vs 38.23 ％,P ＜ 0.05) discontinued for 1 years.The liver function damage of the goserelin group was significantly lower than the mifepristone group (2.94％ vs 23.53％,P ＜ 0.05).Conclusion It is more significance for using suppression of ovarian function after laparoscopic conservative operation for severe endometriosis.It can increase the pregnancy rate and decrease the recurrence rate.
