中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
3期
391-393
,共3页
阿托伐他汀%脑心通胶囊%脑梗死%动脉硬化%颈动脉
阿託伐他汀%腦心通膠囊%腦梗死%動脈硬化%頸動脈
아탁벌타정%뇌심통효낭%뇌경사%동맥경화%경동맥
Atorvastatin%Naoxintong capsule%Cerebral infarction%Arteriosclerosis%Carotid arteries
目的 探讨阿托伐他汀联合脑心通胶囊治疗脑梗死并颈动脉粥样硬化的临床效果.方法 选择134例经MRI或者头颅CT检查确诊为脑梗死并颈动脉粥样硬化患者,简单随机化法分为两组,对照组67例给予阿托伐他汀与阿司匹林行常规治疗；观察组67例则在常规治疗的基础上,加用脑心通胶囊,两组均治疗1个疗程(6个月).比较分析两组治疗前后血脂、超敏C-反应蛋白水平(hs-CRP)、神经功能缺损评分(NIHSS),颈动脉内中膜厚度(IMT).结果 治疗后两组血脂与治疗前比较,差异均有统计学意义(均P＜0.05)；且治疗后观察组与对照组比较,差异均有统计学意义(均P＜0.05).治疗后两组NIHSS评分、IMT、hs-CRP水平与治疗前比较,差异均有统计学意义(均P＜0.05)；且观察组治疗后NIHSS评分、IMT、hs-CRP水平[分别为(10.08±1.82)分、(1.06±0.13)mm、(3.89±1.41) mg/L]较对照组治疗后[分别为(13.92±2.01)分、(1.24 ±0.15)mm、(5.02±1.52)mg/L]下降明显,差异均有统计学意义(均P＜0.05).结论 阿托伐他汀联合脑心通胶囊治疗脑梗死并颈动脉粥样硬化,疗效明显,值得临床推广使用.
目的 探討阿託伐他汀聯閤腦心通膠囊治療腦梗死併頸動脈粥樣硬化的臨床效果.方法 選擇134例經MRI或者頭顱CT檢查確診為腦梗死併頸動脈粥樣硬化患者,簡單隨機化法分為兩組,對照組67例給予阿託伐他汀與阿司匹林行常規治療；觀察組67例則在常規治療的基礎上,加用腦心通膠囊,兩組均治療1箇療程(6箇月).比較分析兩組治療前後血脂、超敏C-反應蛋白水平(hs-CRP)、神經功能缺損評分(NIHSS),頸動脈內中膜厚度(IMT).結果 治療後兩組血脂與治療前比較,差異均有統計學意義(均P＜0.05)；且治療後觀察組與對照組比較,差異均有統計學意義(均P＜0.05).治療後兩組NIHSS評分、IMT、hs-CRP水平與治療前比較,差異均有統計學意義(均P＜0.05)；且觀察組治療後NIHSS評分、IMT、hs-CRP水平[分彆為(10.08±1.82)分、(1.06±0.13)mm、(3.89±1.41) mg/L]較對照組治療後[分彆為(13.92±2.01)分、(1.24 ±0.15)mm、(5.02±1.52)mg/L]下降明顯,差異均有統計學意義(均P＜0.05).結論 阿託伐他汀聯閤腦心通膠囊治療腦梗死併頸動脈粥樣硬化,療效明顯,值得臨床推廣使用.
목적 탐토아탁벌타정연합뇌심통효낭치료뇌경사병경동맥죽양경화적림상효과.방법 선택134례경MRI혹자두로CT검사학진위뇌경사병경동맥죽양경화환자,간단수궤화법분위량조,대조조67례급여아탁벌타정여아사필림행상규치료；관찰조67례칙재상규치료적기출상,가용뇌심통효낭,량조균치료1개료정(6개월).비교분석량조치료전후혈지、초민C-반응단백수평(hs-CRP)、신경공능결손평분(NIHSS),경동맥내중막후도(IMT).결과 치료후량조혈지여치료전비교,차이균유통계학의의(균P＜0.05)；차치료후관찰조여대조조비교,차이균유통계학의의(균P＜0.05).치료후량조NIHSS평분、IMT、hs-CRP수평여치료전비교,차이균유통계학의의(균P＜0.05)；차관찰조치료후NIHSS평분、IMT、hs-CRP수평[분별위(10.08±1.82)분、(1.06±0.13)mm、(3.89±1.41) mg/L]교대조조치료후[분별위(13.92±2.01)분、(1.24 ±0.15)mm、(5.02±1.52)mg/L]하강명현,차이균유통계학의의(균P＜0.05).결론 아탁벌타정연합뇌심통효낭치료뇌경사병경동맥죽양경화,료효명현,치득림상추엄사용.
Objective To investigate the effect of Atorvastatin Combined Naoxintong Capsule treats to cerebral infarction and carotid atherosclerosis.Methods 134 patients with cerebral infarction and carotid atherosclerosis were diagnosed by MRI or CT scan.They were randomly divided into two groups.67 cases were given atorvastatin versus aspirin received routine treatment in the control group and 67 cases were used Naoxintong capsule in observation group on the basis of routine treatment in the observation group.The blood lipid,serum high sensitive C-reactive protein (hs-CRP) level,neural function defect score (NIHSS),carotid artery intima-media thickness (IMT) were comperred before and after treatment in two groups for treated with 1 courses (6 months).Results The blood lipid had no significant difference between two groups before and after treatment (P ＜ 0.05).The IMT,NIHSS score of high sensitivity C-reactive protein levels had no significant difference in two groups before and after treatment (P ＜ 0.05).The scores of NIHSS,IMT,high sensitive C-reactive protein level respectively (10.08 ± 1.82) ％,(1.06 ± 0.13)mm,(3.89 ± 1.41) mg/L of observation group were more decreased significantly than the control group (respectively (13.92 ±2.01)％,(1.24 ±0.15)mm,(5.02 ± 1.52) mg/L after treatment.Conclusion Atorvastatin Combined Naoxintong Capsule in treatment of cerebral infarction and carotid artery gruel kind hardening shows good therapeutic effect,it is worth for clinical use.
