中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
3期
399-401
,共3页
奥美拉唑%伊托必利%消化不良
奧美拉唑%伊託必利%消化不良
오미랍서%이탁필리%소화불량
Omeprazole%Itopride%Dyspepsia
目的 探讨奥美拉唑联合伊托必利治疗功能性消化不良的临床疗效,并评价其安全性.方法 功能性消化不良(FD)患者246例,按入院顺序随机分为三组,A组82例,口服奥美拉唑20 mg,2次/d;B组82例,口服伊托必利50 mg,3次/d;C组82例,口服奥美拉唑和伊托必利联合治疗,用法同上,三组均治疗4周.治疗结束后观察三组的症状改善情况和临床疗效,并评价安全性.结果 C组改善早饱和餐后饱胀症状的有效率显著高于A组(95.1％、95.3％与64.6％、63.6％),C组改善上腹痛和上腹烧灼感症状的有效率显著高于B组(93.1％、90.8％与67.2％、65.1％),C组治疗的总有效率显著高于A组和B组(分别为91.5％、69.5％、73.2％),差异均有统计学意义(均P＜0.05).结论 奥美拉唑联合伊托必利治疗FD临床疗效确切,安全可靠,值得临床推广和普及.
目的 探討奧美拉唑聯閤伊託必利治療功能性消化不良的臨床療效,併評價其安全性.方法 功能性消化不良(FD)患者246例,按入院順序隨機分為三組,A組82例,口服奧美拉唑20 mg,2次/d;B組82例,口服伊託必利50 mg,3次/d;C組82例,口服奧美拉唑和伊託必利聯閤治療,用法同上,三組均治療4週.治療結束後觀察三組的癥狀改善情況和臨床療效,併評價安全性.結果 C組改善早飽和餐後飽脹癥狀的有效率顯著高于A組(95.1％、95.3％與64.6％、63.6％),C組改善上腹痛和上腹燒灼感癥狀的有效率顯著高于B組(93.1％、90.8％與67.2％、65.1％),C組治療的總有效率顯著高于A組和B組(分彆為91.5％、69.5％、73.2％),差異均有統計學意義(均P＜0.05).結論 奧美拉唑聯閤伊託必利治療FD臨床療效確切,安全可靠,值得臨床推廣和普及.
목적 탐토오미랍서연합이탁필리치료공능성소화불량적림상료효,병평개기안전성.방법 공능성소화불량(FD)환자246례,안입원순서수궤분위삼조,A조82례,구복오미랍서20 mg,2차/d;B조82례,구복이탁필리50 mg,3차/d;C조82례,구복오미랍서화이탁필리연합치료,용법동상,삼조균치료4주.치료결속후관찰삼조적증상개선정황화림상료효,병평개안전성.결과 C조개선조포화찬후포창증상적유효솔현저고우A조(95.1％、95.3％여64.6％、63.6％),C조개선상복통화상복소작감증상적유효솔현저고우B조(93.1％、90.8％여67.2％、65.1％),C조치료적총유효솔현저고우A조화B조(분별위91.5％、69.5％、73.2％),차이균유통계학의의(균P＜0.05).결론 오미랍서연합이탁필리치료FD림상료효학절,안전가고,치득림상추엄화보급.
Objective To study the effect of omeprazole combined itopride in treatment of functional dyspepsia and the safety.Methods 246 patients with functional dyspepsia were randomly divided into three groups,each group of 82 cases.Group A was treated with omeprazole,20mg each time,twice every day.Group B was treated with itopride,50mg each time,three times every day.Group C was treated with omeprazole combined itopride.All groups were treated for four weeks.Improvement of symptoms,clinical curative effect and safety were observed.Results The effective rate of early enough and after dinner full bilge symptoms of group C were 95.1％ and 95.3％,which were significantly higher than 64.6％ and 63.6％ of group A.The effective rate of abdominal pain and epigastric voiding symptoms of group C were 93.1％ and 90.8％,which were significantly higher than 67.2％ and 65.1％ of group B.The total effective rate of group C was 91.5％,which was significantly higher than 69.5％ of group A and 73.2％ of group B.All differences were statistically significant (P ＜ 0.05).Conclusion Omeprazole combined itopride in treatment of functional dyspepsia has definite curative effect,which is safety and worth of clinical promotion and popularization.
