中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
4期
489-491
,共3页
冠状动脉疾病%心钠素%心肌梗死
冠狀動脈疾病%心鈉素%心肌梗死
관상동맥질병%심납소%심기경사
Coronary disease%Atrial natriuretic factor%Myocardial infarction
目的 探讨冠心病(CHD)患者检测外周血脑钠肽临床意义.方法 选择260例CHD患者,根据造影及临床诊断分为稳定型心绞痛(SAP)组95例、不稳定型心绞痛(UAP)组85例,急性心肌梗死(AMI)组80例.另外选择体检的健康人群80例为健康对照组.检测各组研究对象的外周血血浆脑钠肽浓度,冠状动脉病变程度程度采用冠状动脉Gensini积分量化.结果 UAP组和AMI组外周血脑钠肽平均浓度分别为(498.00±87.00) ng/L和(936.00±102.25) ng/L,均明显高于SAP组的(213.46±98.35) ng/L和对照组的(97.63 ±20.07) ng/L(t =8.78、12.01、6.26、2.38,均P＜0.05).Gensini积分≥20分患者外周血脑钠肽明显高于Gensini积分＜20分的患者(P＜0.05).结论 CHD患者外周血脑钠肽浓度高低与冠脉斑块稳定型和病变严重程度有关.
目的 探討冠心病(CHD)患者檢測外週血腦鈉肽臨床意義.方法 選擇260例CHD患者,根據造影及臨床診斷分為穩定型心絞痛(SAP)組95例、不穩定型心絞痛(UAP)組85例,急性心肌梗死(AMI)組80例.另外選擇體檢的健康人群80例為健康對照組.檢測各組研究對象的外週血血漿腦鈉肽濃度,冠狀動脈病變程度程度採用冠狀動脈Gensini積分量化.結果 UAP組和AMI組外週血腦鈉肽平均濃度分彆為(498.00±87.00) ng/L和(936.00±102.25) ng/L,均明顯高于SAP組的(213.46±98.35) ng/L和對照組的(97.63 ±20.07) ng/L(t =8.78、12.01、6.26、2.38,均P＜0.05).Gensini積分≥20分患者外週血腦鈉肽明顯高于Gensini積分＜20分的患者(P＜0.05).結論 CHD患者外週血腦鈉肽濃度高低與冠脈斑塊穩定型和病變嚴重程度有關.
목적 탐토관심병(CHD)환자검측외주혈뇌납태림상의의.방법 선택260례CHD환자,근거조영급림상진단분위은정형심교통(SAP)조95례、불은정형심교통(UAP)조85례,급성심기경사(AMI)조80례.령외선택체검적건강인군80례위건강대조조.검측각조연구대상적외주혈혈장뇌납태농도,관상동맥병변정도정도채용관상동맥Gensini적분양화.결과 UAP조화AMI조외주혈뇌납태평균농도분별위(498.00±87.00) ng/L화(936.00±102.25) ng/L,균명현고우SAP조적(213.46±98.35) ng/L화대조조적(97.63 ±20.07) ng/L(t =8.78、12.01、6.26、2.38,균P＜0.05).Gensini적분≥20분환자외주혈뇌납태명현고우Gensini적분＜20분적환자(P＜0.05).결론 CHD환자외주혈뇌납태농도고저여관맥반괴은정형화병변엄중정도유관.
Objective To explore the detection significance of brain natriuretic peptide in peripheral blood of patients with coronary heart disease(CHD).Methods 260 patients with CHD were selected and divided into 95 cases of stable angina pectoris(SAP) group,85 cases of unstable angina pectoris(UAP) group and 80 cases of acute myocardial infarction(AMI) group according to angiographic and clinical diagnosis.Another 80 cases of healthy people which were taken medical examination were selected as the healthy control group.The peripheral blood plasma brain natriuretic peptide concentration of the study objects were detected,and the severity of coronary lesions was quantified by the coronary Gensini score.Results The peripheral blood brain natriuretic peptide average concentration of UAP group and AMI group was (498.00 ± 87.00) ng/L and (936.00 ± 102.25) ng/L,respectively,which were significantly higher than that of the SAP group [(213.46 ± 98.35) ng/L] and the control group [(97.63 ±20.07) ng/L] (t =8.78,12.01,6.26,2.38,all P ＜ 0.05).The peripheral blood brain natriuretic peptide concentration of patients with Gensini score≥20 points was significantly higher than that of the patients with Gensini score ＜20points(P ＜ 0.05).Conclusion The peripheral blood brain natriuretic peptide concentration of patients with CHD is correlated with coronary plaque stabilization and lesion severity.
