中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
4期
496-498
,共3页
乳腺肿瘤%化学疗法%胃肠外营养%营养状况%免疫功能
乳腺腫瘤%化學療法%胃腸外營養%營養狀況%免疫功能
유선종류%화학요법%위장외영양%영양상황%면역공능
Breast tumor%Chemotherapy%Parenterai nutrition%Nutritional status%Immune function
目的 探讨肠外营养(PN)支持对乳腺癌术后化疗患者的营养状况、免疫功能的影响.方法 将94例乳腺癌术后患者随机分为治疗组(47例)和对照组(47例).所有患者给予CEF方案化疗,治疗组给予谷氨酰胺强化的PN支持治疗,对照组仅给予常规营养支持治疗.比较患者化疗前后营养指标、免疫指标的变化及不良反应.结果 化疗后,治疗组的血清白蛋白(ALB)、前白蛋白(PA)及血红蛋白(Hb)水平较化疗前下降不明显(均P＞0.05),但对照组ALB、PA及HB水平较化疗前显著下降(均P＜0.05)；化疗后,两组CD4、CD8、CD4/CD8和IgA、IgG、IgM水平均较化疗前有所下降(均P＜0.05),而治疗组免疫指标水平均显著高于对照组(均P＜0.05)；两组均表现为恶心呕吐、腹泻及轻度骨髓抑制等不良反应,但对照组患者体质量减少(0.91 ±0.53) kg,治疗组体质量增加(0.45 ±0.21) kg,差异有统计学意义(=5.53,P＜0.05).结论 乳腺癌患者术后化疗期间给予PN治疗,可改善化疗患者的营养状况以及免疫功能,提高其对化疗的耐受性,从而提高疗效及改善预后.
目的 探討腸外營養(PN)支持對乳腺癌術後化療患者的營養狀況、免疫功能的影響.方法 將94例乳腺癌術後患者隨機分為治療組(47例)和對照組(47例).所有患者給予CEF方案化療,治療組給予穀氨酰胺彊化的PN支持治療,對照組僅給予常規營養支持治療.比較患者化療前後營養指標、免疫指標的變化及不良反應.結果 化療後,治療組的血清白蛋白(ALB)、前白蛋白(PA)及血紅蛋白(Hb)水平較化療前下降不明顯(均P＞0.05),但對照組ALB、PA及HB水平較化療前顯著下降(均P＜0.05)；化療後,兩組CD4、CD8、CD4/CD8和IgA、IgG、IgM水平均較化療前有所下降(均P＜0.05),而治療組免疫指標水平均顯著高于對照組(均P＜0.05)；兩組均錶現為噁心嘔吐、腹瀉及輕度骨髓抑製等不良反應,但對照組患者體質量減少(0.91 ±0.53) kg,治療組體質量增加(0.45 ±0.21) kg,差異有統計學意義(=5.53,P＜0.05).結論 乳腺癌患者術後化療期間給予PN治療,可改善化療患者的營養狀況以及免疫功能,提高其對化療的耐受性,從而提高療效及改善預後.
목적 탐토장외영양(PN)지지대유선암술후화료환자적영양상황、면역공능적영향.방법 장94례유선암술후환자수궤분위치료조(47례)화대조조(47례).소유환자급여CEF방안화료,치료조급여곡안선알강화적PN지지치료,대조조부급여상규영양지지치료.비교환자화료전후영양지표、면역지표적변화급불량반응.결과 화료후,치료조적혈청백단백(ALB)、전백단백(PA)급혈홍단백(Hb)수평교화료전하강불명현(균P＞0.05),단대조조ALB、PA급HB수평교화료전현저하강(균P＜0.05)；화료후,량조CD4、CD8、CD4/CD8화IgA、IgG、IgM수평균교화료전유소하강(균P＜0.05),이치료조면역지표수평균현저고우대조조(균P＜0.05)；량조균표현위악심구토、복사급경도골수억제등불량반응,단대조조환자체질량감소(0.91 ±0.53) kg,치료조체질량증가(0.45 ±0.21) kg,차이유통계학의의(=5.53,P＜0.05).결론 유선암환자술후화료기간급여PN치료,가개선화료환자적영양상황이급면역공능,제고기대화료적내수성,종이제고료효급개선예후.
Objective To explore the influence of parenterai nutrition(PN) on nutritional status and immune function in breast cancer patients undergoing postoperative chemotherapy.Methods 94 patients with breast cancer postoperative patients were randomly divided into the treatment group(47 cases) and the control group(47 cases).All the patients were given chemotherapy with VBP.The treatment group was given glutamine fortified PN,and the control group was given normal nutrition support,respectively.The nutritional status and immune function before and after chemotherapy,and main toxicities were observed.Results Compared with those before chemotherapy,there were no significant decrease on the level of ALB,PA and HB in treatment group(all P ＞ 0.05),while those indicators in control group was significantly decreased (all P ＜ 0.05).After chemotherapy,CD4,CD8,CD4/CD8 and IgA,IgG,IgM levels of the two groups were lower than those before chemotherapy (all P ＜ 0.05),and the levels of immune indicators of the treatment group were significantly higher than those of the control group(all P ＜ 0.05).The main toxicities in two groups were nausea and vomiting,diarrhea and mild bone marrow suppression,and the body weight in control group decreased (0.91 ± 0.53)kg,while it increased (0.45 ± 0.21)kg in treatment group (t =5.53,P ＜0.05).Conclusion PN treatment for breast cancer patients during chemotherapy can improve nutrition status and immune function,enhance the tolerance of chemotherapy,so as to improve curative effect and prognosis.
