中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
5期
708-710
,共3页
新辅助化疗%局部晚期宫颈癌%肿瘤体积%转移
新輔助化療%跼部晚期宮頸癌%腫瘤體積%轉移
신보조화료%국부만기궁경암%종류체적%전이
Neoadjuvant chemotherapy%Locally advanced cervical cancer%Tumor volume%Transfer
目的 探讨新辅助化疗方案在局部晚期宫颈癌患者中的应用效果及临床价值.方法 将102例局部晚期宫颈癌患者按数字表法随机分为观察组和对照组,观察组在新辅助化疗后给予手术治疗,对照组直接给予手术治疗,观察两组患者手术时间、术中出血量及术后病理检查结果情况,并对观察组患者化疗疗效及毒副反应进行评价.结果 观察组化疗有效率为74.51％,毒副反应均可耐受；观察组手术时间及术中出血量均明显低于对照组(均P＜0.05);观察组患者手术损伤及术后并发症的发生率均明显低于对照组(均P＜0.05)；观察组术后盆腔淋巴结转移及阴道切缘残留的发生率均明显低于对照组(均P＜0.05).结论 NACT用于局部晚期宫颈癌中,能在缩小肿瘤体积、降低肿瘤分期的同时可降低其手术难度,对减轻手术损伤、减少术后并发症、防止复发和转移均有积极意义,可作为目前治疗局部晚期宫颈癌的一种较佳辅助治疗方案..
目的 探討新輔助化療方案在跼部晚期宮頸癌患者中的應用效果及臨床價值.方法 將102例跼部晚期宮頸癌患者按數字錶法隨機分為觀察組和對照組,觀察組在新輔助化療後給予手術治療,對照組直接給予手術治療,觀察兩組患者手術時間、術中齣血量及術後病理檢查結果情況,併對觀察組患者化療療效及毒副反應進行評價.結果 觀察組化療有效率為74.51％,毒副反應均可耐受；觀察組手術時間及術中齣血量均明顯低于對照組(均P＜0.05);觀察組患者手術損傷及術後併髮癥的髮生率均明顯低于對照組(均P＜0.05)；觀察組術後盆腔淋巴結轉移及陰道切緣殘留的髮生率均明顯低于對照組(均P＜0.05).結論 NACT用于跼部晚期宮頸癌中,能在縮小腫瘤體積、降低腫瘤分期的同時可降低其手術難度,對減輕手術損傷、減少術後併髮癥、防止複髮和轉移均有積極意義,可作為目前治療跼部晚期宮頸癌的一種較佳輔助治療方案..
목적 탐토신보조화료방안재국부만기궁경암환자중적응용효과급림상개치.방법 장102례국부만기궁경암환자안수자표법수궤분위관찰조화대조조,관찰조재신보조화료후급여수술치료,대조조직접급여수술치료,관찰량조환자수술시간、술중출혈량급술후병리검사결과정황,병대관찰조환자화료료효급독부반응진행평개.결과 관찰조화료유효솔위74.51％,독부반응균가내수；관찰조수술시간급술중출혈량균명현저우대조조(균P＜0.05);관찰조환자수술손상급술후병발증적발생솔균명현저우대조조(균P＜0.05)；관찰조술후분강림파결전이급음도절연잔류적발생솔균명현저우대조조(균P＜0.05).결론 NACT용우국부만기궁경암중,능재축소종류체적、강저종류분기적동시가강저기수술난도,대감경수술손상、감소술후병발증、방지복발화전이균유적겁의의,가작위목전치료국부만기궁경암적일충교가보조치료방안..
Objective To investigate the effects and clinical value of neoadjuvant chemotherapy in patients with locally advanced cervical cancer.Methods 102 cases with locally advanced cervical cancer treated were randomly divided into observation group and control group,the observation group received the surgery after the neoadjuvant chemotherapy,and the control group was given a direct surgical treatment.Operative time,blood loss and postoperative pathologic results were observed,and chemotherapy and toxicity evaluation were made for the observation group.Results The chemotherapy effective rate of the observation group was 74.51％,and the toxicity could be tolerated;the operation time and blood loss of the observation group were significantly lower than those of the control group(all P ＜ 0.05) ;surgical trauma and postoperative complications' occurrence rate of the observation group were significantly lower than those of the control group (all P ＜ 0.05) ; pelvic lymph node metastasis and vaginal cutting edge of the residues of the observation group were significantly lower than those of the control group (all P ＜ 0.05).Conclusion For locally advanced cervical cancer,NACT has a positive significance in reducing the tumor volume,low-er tumor stage,and at the same time reducing the difficulty of operation,surgical trauma,postoperative complications,and preventing recurrence and metastasis,which can be used as a better adjuvant treatment program for locally advanced cervical cancer.
