中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
7期
966-968
,共3页
刘伟华%杨宾%张北宁%亢秋芳
劉偉華%楊賓%張北寧%亢鞦芳
류위화%양빈%장북저%항추방
紫癜,过敏性%肾功能不全%胱抑素C%乙酰氨基葡糖苷酶
紫癜,過敏性%腎功能不全%胱抑素C%乙酰氨基葡糖苷酶
자전,과민성%신공능불전%광억소C%을선안기포당감매
Purpura,schoenlein-henoch%Renal insufficiency%Cystatin C%Acetylglucosaminidase
目的 研究血清胱抑素C、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)水平在小儿过敏性紫癜(HSP)肾损伤中的变化及临床意义.方法 60例过敏性紫癜患儿按照尿常规和生化检查结果异常程度分为肾损A组、肾损B组、非肾损组;同龄健康人28例为对照组.采用酶联免疫双抗夹心法检测血清胱抑素C和尿NAG酶.结果 尿NAG酶水平:肾损A组(127.11±15.63) ng/L、肾损B组(132.75±19.83) ng/L,均高于非肾损组的(111.36 ±20.10)ng/L(F =7.324,P＜0.05);而非肾损组与对照组(108.14±13.83) ng/L差异无统计学意义.血清胱抑素C水平:肾损A组(1.18 ±0.13)mg/L、肾损B组(1.19 ±0.17) mg/L、非肾损组(1.16 ±0.11)mg/L,均显著高于对照组的(0.79 ±0.14) mg/L(P ＜0.05).结论 尿NAG酶、血清胱抑素C可反映HSP患儿肾脏损害程度,联合检测可以作为小儿HSP肾脏损伤的早期、灵敏诊断指标.
目的 研究血清胱抑素C、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)水平在小兒過敏性紫癜(HSP)腎損傷中的變化及臨床意義.方法 60例過敏性紫癜患兒按照尿常規和生化檢查結果異常程度分為腎損A組、腎損B組、非腎損組;同齡健康人28例為對照組.採用酶聯免疫雙抗夾心法檢測血清胱抑素C和尿NAG酶.結果 尿NAG酶水平:腎損A組(127.11±15.63) ng/L、腎損B組(132.75±19.83) ng/L,均高于非腎損組的(111.36 ±20.10)ng/L(F =7.324,P＜0.05);而非腎損組與對照組(108.14±13.83) ng/L差異無統計學意義.血清胱抑素C水平:腎損A組(1.18 ±0.13)mg/L、腎損B組(1.19 ±0.17) mg/L、非腎損組(1.16 ±0.11)mg/L,均顯著高于對照組的(0.79 ±0.14) mg/L(P ＜0.05).結論 尿NAG酶、血清胱抑素C可反映HSP患兒腎髒損害程度,聯閤檢測可以作為小兒HSP腎髒損傷的早期、靈敏診斷指標.
목적 연구혈청광억소C、뇨N-을선-β-D-안기포도당감매(NAG)수평재소인과민성자전(HSP)신손상중적변화급림상의의.방법 60례과민성자전환인안조뇨상규화생화검사결과이상정도분위신손A조、신손B조、비신손조;동령건강인28례위대조조.채용매련면역쌍항협심법검측혈청광억소C화뇨NAG매.결과 뇨NAG매수평:신손A조(127.11±15.63) ng/L、신손B조(132.75±19.83) ng/L,균고우비신손조적(111.36 ±20.10)ng/L(F =7.324,P＜0.05);이비신손조여대조조(108.14±13.83) ng/L차이무통계학의의.혈청광억소C수평:신손A조(1.18 ±0.13)mg/L、신손B조(1.19 ±0.17) mg/L、비신손조(1.16 ±0.11)mg/L,균현저고우대조조적(0.79 ±0.14) mg/L(P ＜0.05).결론 뇨NAG매、혈청광억소C가반영HSP환인신장손해정도,연합검측가이작위소인HSP신장손상적조기、령민진단지표.
Objective To investigate the change of the serum levels of cystatin C,urinary NAG enzyme in the children affected by HSP and its cliracal significance.Methods 60 children with HSP were divided into three groups based on urine routine and abnormal degrees of biochemícal examination results,which were kidney injury group A (KI-Group A),kidney injury group B (KI-Group B),and non-kidney injury group (non-KI-Group).Selected 28 healthy children with the same phase and the same age as the control group.A sandwich enzyme-linked immunosorbent assay(ELISA) was employed to determine the values of cystatin C,urinary NAG enzyme.Results Urinary NAG enzyme in KI-Group A (127.11 ± 15.63) ng/L and KI-Group B (132.75 ± 19.83) ng/L were significantly higher than the control group (111.36 ± 20.10) ng/L (F =7.324,P ＜ 0.05),and there was no difference between non-KI-Group (108.14 ± 13.83) ng/L and the control group.Cystatin C in KI-Group A (1.18 ±0.13) mg/L,KI-Group B (1.19 ±0.17)mg/L and non-KI-Group (1.16 ±0.11)mg/L were all significantly higher than the control group (0.79 ±0.14)mg/L (P ＜ 0.05).Conclusion Cystatin C and urinary NAG enzyme in children with HSP were significantly abnormal,and may be used as early indexes reflecting the glomerular injury.The relationship of the two above indicators had positive correlation,and the combined employment of them had the dadvantages of early detection,high sensitivity and accurate diagnosis.
