中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
7期
1020-1021
,共2页
精神病%血药浓度%碳酸锂
精神病%血藥濃度%碳痠鋰
정신병%혈약농도%탄산리
Psychosis disorders%Plasma concentration%Lithium carbonate
目的 对应用碳酸锂治疗精神病患者进行血锂浓度监测,分析其影响因素,为临床合理用药提供参考依据.方法 收集2011年9月至2012年9月服用碳酸锂治疗的252例精神病患者的临床资料,采用上海迅达DX684电解质分析仪血锂浓度,并分析结果及影响因素.结果 服碳酸锂的252例患者中,有56例(22％)血锂浓度小于0.6 mmol/L,188例(75％)在0.6～ 1.2 mmol/L,8例(3％)大于1.2 mmol/L.有179例(71％)患者有效,有69例(27％)患者无效,有4例(2％)患者发生锂中毒.随口服给药浓度逐渐增加,患者有效率也逐渐增高,发生锂中毒患者也逐渐增加.血锂浓度与血脂异常、溶血、肾功能不全、检测季节(夏季)等因素有关(P＜0.05).结论 临床应用碳酸锂应根据血锂浓度监测和临床特征实施个体化给药方案,并注意排除影响因素,为临床治疗提供依据.
目的 對應用碳痠鋰治療精神病患者進行血鋰濃度鑑測,分析其影響因素,為臨床閤理用藥提供參攷依據.方法 收集2011年9月至2012年9月服用碳痠鋰治療的252例精神病患者的臨床資料,採用上海迅達DX684電解質分析儀血鋰濃度,併分析結果及影響因素.結果 服碳痠鋰的252例患者中,有56例(22％)血鋰濃度小于0.6 mmol/L,188例(75％)在0.6～ 1.2 mmol/L,8例(3％)大于1.2 mmol/L.有179例(71％)患者有效,有69例(27％)患者無效,有4例(2％)患者髮生鋰中毒.隨口服給藥濃度逐漸增加,患者有效率也逐漸增高,髮生鋰中毒患者也逐漸增加.血鋰濃度與血脂異常、溶血、腎功能不全、檢測季節(夏季)等因素有關(P＜0.05).結論 臨床應用碳痠鋰應根據血鋰濃度鑑測和臨床特徵實施箇體化給藥方案,併註意排除影響因素,為臨床治療提供依據.
목적 대응용탄산리치료정신병환자진행혈리농도감측,분석기영향인소,위림상합리용약제공삼고의거.방법 수집2011년9월지2012년9월복용탄산리치료적252례정신병환자적림상자료,채용상해신체DX684전해질분석의혈리농도,병분석결과급영향인소.결과 복탄산리적252례환자중,유56례(22％)혈리농도소우0.6 mmol/L,188례(75％)재0.6～ 1.2 mmol/L,8례(3％)대우1.2 mmol/L.유179례(71％)환자유효,유69례(27％)환자무효,유4례(2％)환자발생리중독.수구복급약농도축점증가,환자유효솔야축점증고,발생리중독환자야축점증가.혈리농도여혈지이상、용혈、신공능불전、검측계절(하계)등인소유관(P＜0.05).결론 림상응용탄산리응근거혈리농도감측화림상특정실시개체화급약방안,병주의배제영향인소,위림상치료제공의거.
Objective To monitor the lithium level in serum of patients who has taken lithium carbonate and analyze its influencing factor,to explore the relationship between lithium level in serum and chronic lithium intoxication.Methods The lithium level was determined by electrolytic analyzer with electrode method and results from September in 2011 to September in 2012 were retrospectively analyzed.Results The lithium levels of 252 cases were 56cases (22％) under 0.6mmol/L,188 cases (75 ％) between 0.6-1.2mmol/L and 8 cases (3％) above 1.2mmol/L.179 cases (71％) were effective and 69 cases (27 ％) were ineffective,4 cases (2％) showed lithium toxic.The clinical therapeutic effect was improved with the concentration gradually in creasing,and the poisoning rate was getting higher.Plasma lithium concentration is closely related to hyperlipoidemia,hemolysis,nephropathy and the incidence seasons.Conclusion We should attach importance to the therapy drug monitoring dosage,clinical feature,and removing influencing factor which are the basis to guide the clinical medication.This way can adjust the dosage for individual administration.
