CAJ | 학술논문

目的探讨依那普利联合叶酸治疗对原发性高血压患者血管内皮功能及尿微量白蛋白(UMA)的影响.方法 120例原发性高血压患者按数字表法随机分为对照组和治疗组,各60例.对照组给予依那普利降压治疗(10 mg,每天1次),观察组给予依那普利联合叶酸片(0.4 mg,每天1次)治疗,疗程8周.观察治疗前后血压、血浆同型半胱氨酸(Hcy)、肱动脉内皮依赖性舒张功能(FMD)和UMA变化.结果观察组与对照组降压有效率差异无统计学意义(75.0％与71.7％,P＞0.05)；观察组Hcy、FMD和UMA均较对照组明显改善[分别为(10.2±5.8) μmol/L与(16.6±8.1)μmol/L、(14.8±5.4)％与(8.2±3.5)％、(14.8±5.4)mg/L与(31.6±9.5) mg/L,t=3.641、7.325、8.221,均P＜0.05].结论依那普利联合叶酸治疗原发性高血压能降低Hcy,修复血管内皮功能,减少UMA.
목적 탐토의나보리연합협산치료대원발성고혈압환자혈관내피공능급뇨미량백단백(UMA)적영향.방법 120례원발성고혈압환자안수자표법수궤분위대조조화치료조,각60례.대조조급여의나보리강압치료(10 mg,매천1차),관찰조급여의나보리연합협산편(0.4 mg,매천1차)치료,료정8주.관찰치료전후혈압、혈장동형반광안산(Hcy)、굉동맥내피의뢰성서장공능(FMD)화UMA변화.결과 관찰조여대조조강압유효솔차이무통계학의의(75.0％여71.7％,P＞0.05)；관찰조Hcy、FMD화UMA균교대조조명현개선[분별위(10.2±5.8) μmol/L여(16.6±8.1)μmol/L、(14.8±5.4)％여(8.2±3.5)％、(14.8±5.4)mg/L여(31.6±9.5) mg/L,t=3.641、7.325、8.221,균P＜0.05].결론 의나보리연합협산치료원발성고혈압능강저Hcy,수복혈관내피공능,감소UMA.
Objective To explore the effect of enalapril combined with folate acid on endothelial function and urine microalbumin(UMA) in patients with hypertension.Methods 120 patients with hypertension were randomly divided into two groups:control group (n =60) was given enalapril 10.0mg/d,observation group (n =60) received enalapril 10.0mg + folic acid 0.4mg/d.The total treatment period was 8 weeks.Blood pressure,plasma homocysteine (Hcy),flow mediated dilation (FMD) and UMA were examined.Results The efficacy of pressure releasinghad no significant difference between two groups.Hcy[(10.2 ± 5.8) μmol/L vs (16.6 ±-8.1) μmol/L,t =3.641],FMD[(14.8 ±5.4)％ vs (8.2±3.5)％,t =7.325] and UMA[(14.8 ±5.4)mg/L vs (31.6 ±9.5)mg/L,t =8.221] of two groups were significantly different after treatment.Conclusion Combination therapy of enalapril and folate acid can decrease plasma Hey and UMA,restore vascular endothelium function in patients with hypertension.