中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
12期
1801-1802
,共2页
头痛%乙哌立松%普罗喹宗
頭痛%乙哌立鬆%普囉喹宗
두통%을고립송%보라규종
Headache%Eperisone%Proquazone
目的 观察乙哌立松联合普罗喹宗治疗紧张性头痛的临床疗效以及不良反应的发生情况.方法 285例紧张性头痛的患者按数字表法随机分成A、B、C三组,A组95例患者单纯使用乙哌立松治疗,B组95例患者单纯采用普罗喹宗治疗,C组95例患者联合使用乙哌立松和普罗喹宗法进行治疗.观察患者头痛发作的频率、发作平均时间,并对患者进行VAS评分,从而评价患者症状缓解的情况.结果 C组患者治疗后头痛的发作频率、发作持续时间及VAS评分分别为(2.01±1.02)次/周、(4.28±2.14)h、(3.42±1.03)分,显著小于A组、B组(t=8.682、7.879、13.396、14.140、16.408、21.481,均P＜0.05).C组不良反应发生率37.89％,与A组(36.84％)、B组(34.74％)差异均无统计学意义(均P＞0.05),但C组嗜睡淡漠的发生率显著高于A、B组(x2=34.381、13.821,均P＜0.05).结论 乙哌立松联合普罗喹宗可以有效减少紧张性头痛患者发作的频率、持续时间及疼痛程度,不会增加不良反应的发生,具有较好的安全性,值得推广.但因中枢抑制作用,不适用于高危险职业或户外操作人员.
目的 觀察乙哌立鬆聯閤普囉喹宗治療緊張性頭痛的臨床療效以及不良反應的髮生情況.方法 285例緊張性頭痛的患者按數字錶法隨機分成A、B、C三組,A組95例患者單純使用乙哌立鬆治療,B組95例患者單純採用普囉喹宗治療,C組95例患者聯閤使用乙哌立鬆和普囉喹宗法進行治療.觀察患者頭痛髮作的頻率、髮作平均時間,併對患者進行VAS評分,從而評價患者癥狀緩解的情況.結果 C組患者治療後頭痛的髮作頻率、髮作持續時間及VAS評分分彆為(2.01±1.02)次/週、(4.28±2.14)h、(3.42±1.03)分,顯著小于A組、B組(t=8.682、7.879、13.396、14.140、16.408、21.481,均P＜0.05).C組不良反應髮生率37.89％,與A組(36.84％)、B組(34.74％)差異均無統計學意義(均P＞0.05),但C組嗜睡淡漠的髮生率顯著高于A、B組(x2=34.381、13.821,均P＜0.05).結論 乙哌立鬆聯閤普囉喹宗可以有效減少緊張性頭痛患者髮作的頻率、持續時間及疼痛程度,不會增加不良反應的髮生,具有較好的安全性,值得推廣.但因中樞抑製作用,不適用于高危險職業或戶外操作人員.
목적 관찰을고립송연합보라규종치료긴장성두통적림상료효이급불량반응적발생정황.방법 285례긴장성두통적환자안수자표법수궤분성A、B、C삼조,A조95례환자단순사용을고립송치료,B조95례환자단순채용보라규종치료,C조95례환자연합사용을고립송화보라규종법진행치료.관찰환자두통발작적빈솔、발작평균시간,병대환자진행VAS평분,종이평개환자증상완해적정황.결과 C조환자치료후두통적발작빈솔、발작지속시간급VAS평분분별위(2.01±1.02)차/주、(4.28±2.14)h、(3.42±1.03)분,현저소우A조、B조(t=8.682、7.879、13.396、14.140、16.408、21.481,균P＜0.05).C조불량반응발생솔37.89％,여A조(36.84％)、B조(34.74％)차이균무통계학의의(균P＞0.05),단C조기수담막적발생솔현저고우A、B조(x2=34.381、13.821,균P＜0.05).결론 을고립송연합보라규종가이유효감소긴장성두통환자발작적빈솔、지속시간급동통정도,불회증가불량반응적발생,구유교호적안전성,치득추엄.단인중추억제작용,불괄용우고위험직업혹호외조작인원.
Objective To observe the clinical efficacy and adverse reactions of proquazone combined with eperisone in treating tension headache.Methods 285 tension headache patients in our hospital from 2009 to 2011were randomly divided into A,B,C three groups.Group A with 95 cases used only eperisone treatment,while B group with 95 cases used only proquazone.Group C with 95 cases received eperisone combined with proquazone treatment.The frequency of migraine attacks,the attack average time,and VAS score of patients were observed.Results The headache frequency,seizure duration and VAS score of group C was (2.01 ± 1.02) times/week,(4.28 ± 2.14) h,(3.42 ± 1.03) points,which were significantly less than those in group A and group B (t =8.682,7.879,13.396,14.140,16.408,21.481,all P ＜ 0.05).The incidence rate of adverse reaction of group C was 37.89％,that in group A was 36.84％,and group B was 34.73％.The difference among them was not statistically significant(P ＞ 0.05).But the incidence rate of drowsiness and indifferent symptom in group C was significandy higher than A and B group.The difference was statistically significant (x2 =34.381,13.821,all P ＜ 0.05).Conclusion Eperisone combined with proquazone could treat tension headaches well,because it can effectively reduce the frequency of migraine attacks in patients as well as the degree of pain.And it could also alleviate the patients' symptoms.In addition,the combination therapy did not increase the incidence rate of adverse reactions in patients.So it has better security and good cilinical promotion.But it couldn't be proscribed to the people with high-risk occupation for its suppression to CNS.
