中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
12期
1814-1816
,共3页
冠状动脉疾病%心室功能,左%C反应蛋白质%肌钙蛋白T
冠狀動脈疾病%心室功能,左%C反應蛋白質%肌鈣蛋白T
관상동맥질병%심실공능,좌%C반응단백질%기개단백T
Coronary heart disease%Ventricular function,left%C-reactive protein%Troponin T
目的 研究冠心病患者血清超敏C-反应蛋白(Hs-CRP)、超敏肌钙蛋白T(Hs-cTnT)的测定及分析两者与左心室功能的关系.方法 100例冠心病患者(观察组)和50例(对照组)年龄相当的健康受试者纳入该研究,分别测定左心室功能以及血清Hs-CRP和Hs-cTnT水平.结果 与对照组相比,观察组Hs-CRF和Hs-cTnT水平明显升高(t=11.745、7.803,均P＜0.01),观察组左室舒张末内径(LVEDD)水平显著升高(t =4.984,P＜0.01),而左室射血分数(LVEF)和左室短轴缩短率(FS)均显著降低(t=5.021、4.672,均P＜0.01).观察组不同YNHA分级,其Hs-CRF、Hs-cTnT水平、LVEF、LVEDD及FS等差异均有统计学意义(F=89.463、143.463、24.352、30.621、15.724,均P＜0.01).相关分析结果显示,Hs-CRP、Hs-cTnT水平分别与NYHA分级、LVEDD正相关(r=0.849、0.752、0.807、0.785,均P＜0.05),Hs-CRP、Hs-cTnT水平分别与LVEF、FS负相关(r=-0.605、-0.754、-0.536、-0.806,均P＜0.05).结论 冠心病患者血清Hs-CRP和Hs-cTnT水平显著升高,并且与心脏功能显著相关,可作为诊断冠心病心脏功能的指标.
目的 研究冠心病患者血清超敏C-反應蛋白(Hs-CRP)、超敏肌鈣蛋白T(Hs-cTnT)的測定及分析兩者與左心室功能的關繫.方法 100例冠心病患者(觀察組)和50例(對照組)年齡相噹的健康受試者納入該研究,分彆測定左心室功能以及血清Hs-CRP和Hs-cTnT水平.結果 與對照組相比,觀察組Hs-CRF和Hs-cTnT水平明顯升高(t=11.745、7.803,均P＜0.01),觀察組左室舒張末內徑(LVEDD)水平顯著升高(t =4.984,P＜0.01),而左室射血分數(LVEF)和左室短軸縮短率(FS)均顯著降低(t=5.021、4.672,均P＜0.01).觀察組不同YNHA分級,其Hs-CRF、Hs-cTnT水平、LVEF、LVEDD及FS等差異均有統計學意義(F=89.463、143.463、24.352、30.621、15.724,均P＜0.01).相關分析結果顯示,Hs-CRP、Hs-cTnT水平分彆與NYHA分級、LVEDD正相關(r=0.849、0.752、0.807、0.785,均P＜0.05),Hs-CRP、Hs-cTnT水平分彆與LVEF、FS負相關(r=-0.605、-0.754、-0.536、-0.806,均P＜0.05).結論 冠心病患者血清Hs-CRP和Hs-cTnT水平顯著升高,併且與心髒功能顯著相關,可作為診斷冠心病心髒功能的指標.
목적 연구관심병환자혈청초민C-반응단백(Hs-CRP)、초민기개단백T(Hs-cTnT)적측정급분석량자여좌심실공능적관계.방법 100례관심병환자(관찰조)화50례(대조조)년령상당적건강수시자납입해연구,분별측정좌심실공능이급혈청Hs-CRP화Hs-cTnT수평.결과 여대조조상비,관찰조Hs-CRF화Hs-cTnT수평명현승고(t=11.745、7.803,균P＜0.01),관찰조좌실서장말내경(LVEDD)수평현저승고(t =4.984,P＜0.01),이좌실사혈분수(LVEF)화좌실단축축단솔(FS)균현저강저(t=5.021、4.672,균P＜0.01).관찰조불동YNHA분급,기Hs-CRF、Hs-cTnT수평、LVEF、LVEDD급FS등차이균유통계학의의(F=89.463、143.463、24.352、30.621、15.724,균P＜0.01).상관분석결과현시,Hs-CRP、Hs-cTnT수평분별여NYHA분급、LVEDD정상관(r=0.849、0.752、0.807、0.785,균P＜0.05),Hs-CRP、Hs-cTnT수평분별여LVEF、FS부상관(r=-0.605、-0.754、-0.536、-0.806,균P＜0.05).결론 관심병환자혈청Hs-CRP화Hs-cTnT수평현저승고,병차여심장공능현저상관,가작위진단관심병심장공능적지표.
Objective To research the determination of hypersensitivity C-reactive protein(Hs-CRP) and cardiac troponin T(Hs-cTnT) in patients with coronary heart disease,and to analyze the correlation with cardiac function.Methods The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT in 100 patients with coronary heart disease and 50 healthy subjects were detected.Results The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT were significantly different in patients with coronary heart disease and healthy subjects(P ＜0.01).The function of left ventricle and the serum levels of Hs-CRP and Hs-cTnT were significantly different in coronary heart disease patients with different New York Heart Association class(P ＜ 0.01).The serum levels of Hs-CRP and Hs-cTnT were positively correlated with class of New York Heart Association,left ventricular end diastolic diameter,and negatively correlated with left ventricular ejection fraction and fraction shortening (Absolute value of r:0.536 ～ 0.849,P ＜ 0.05).Conclusion The serum levels of Hs-CRP and Hs-cTnT significantly increase in patients with coronary heart disease,which is correlated to function of left ventricle,and it can be used as the indicators of cardiac function in patients with coronary heart disease.
