中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
12期
1837-1839
,共3页
关节炎,类风湿%人软骨糖蛋白39%骨桥蛋白%类风湿因子
關節炎,類風濕%人軟骨糖蛋白39%骨橋蛋白%類風濕因子
관절염,류풍습%인연골당단백39%골교단백%류풍습인자
Arthritis,rheumatoid%Human cartilage glycoprotein-39%Osteopontin%Rheumatoid factor
目的 探讨类风湿关节炎患者血清人软骨糖蛋白39(HC gP39)、骨桥蛋白(OPN)及类风湿因子(RF)水平变化及其临床意义.方法 采用ELISA法检测98例类风湿关节炎患者(观察组)血清HC gP39、OPN含量,免疫散射浊度法检测RF水平,并与98例健康人(对照组)比较分析.结果 观察组HC gP39、OPN和RF水平均显著高于对照组(t=20.25、32.71、36.34,均P＜0.01),且观察组中活动期患者血清HC gP39、OPN和RF水平高于非活动期(t=24.22、45.62、50.15,均P＜0.05)；RA患者Ⅰ期与Ⅱ期、Ⅱ期与Ⅲ期、Ⅲ期与Ⅳ期血清HC gP39、OPN水平差异均有统计学意义(F=18.48、12.36,均P＜0.05)；相关性分析表明,RA患者血清RF水平与HC gP39、OPN水平呈正相关(r=0.682、0.656,均P＜0.01),HC gP39水平与OPN也呈正相关(r =0.608,P＜0.01).结论 HC gP39、OPN及RF在类风湿关节炎发生发展过程中可能起重要作用,其可作为判断类风湿关节炎活动性和不同分期的重要指标之一.
目的 探討類風濕關節炎患者血清人軟骨糖蛋白39(HC gP39)、骨橋蛋白(OPN)及類風濕因子(RF)水平變化及其臨床意義.方法 採用ELISA法檢測98例類風濕關節炎患者(觀察組)血清HC gP39、OPN含量,免疫散射濁度法檢測RF水平,併與98例健康人(對照組)比較分析.結果 觀察組HC gP39、OPN和RF水平均顯著高于對照組(t=20.25、32.71、36.34,均P＜0.01),且觀察組中活動期患者血清HC gP39、OPN和RF水平高于非活動期(t=24.22、45.62、50.15,均P＜0.05)；RA患者Ⅰ期與Ⅱ期、Ⅱ期與Ⅲ期、Ⅲ期與Ⅳ期血清HC gP39、OPN水平差異均有統計學意義(F=18.48、12.36,均P＜0.05)；相關性分析錶明,RA患者血清RF水平與HC gP39、OPN水平呈正相關(r=0.682、0.656,均P＜0.01),HC gP39水平與OPN也呈正相關(r =0.608,P＜0.01).結論 HC gP39、OPN及RF在類風濕關節炎髮生髮展過程中可能起重要作用,其可作為判斷類風濕關節炎活動性和不同分期的重要指標之一.
목적 탐토류풍습관절염환자혈청인연골당단백39(HC gP39)、골교단백(OPN)급류풍습인자(RF)수평변화급기림상의의.방법 채용ELISA법검측98례류풍습관절염환자(관찰조)혈청HC gP39、OPN함량,면역산사탁도법검측RF수평,병여98례건강인(대조조)비교분석.결과 관찰조HC gP39、OPN화RF수평균현저고우대조조(t=20.25、32.71、36.34,균P＜0.01),차관찰조중활동기환자혈청HC gP39、OPN화RF수평고우비활동기(t=24.22、45.62、50.15,균P＜0.05)；RA환자Ⅰ기여Ⅱ기、Ⅱ기여Ⅲ기、Ⅲ기여Ⅳ기혈청HC gP39、OPN수평차이균유통계학의의(F=18.48、12.36,균P＜0.05)；상관성분석표명,RA환자혈청RF수평여HC gP39、OPN수평정정상관(r=0.682、0.656,균P＜0.01),HC gP39수평여OPN야정정상관(r =0.608,P＜0.01).결론 HC gP39、OPN급RF재류풍습관절염발생발전과정중가능기중요작용,기가작위판단류풍습관절염활동성화불동분기적중요지표지일.
Objective To explore the changes and clinical significance of serum human cartilage glycoprotein-39(HC gP39),osteopontin (OPN) and rheumatoid factor (RF) in patients with rheumatoid arthritis (RA).Methods Serum HC gP39,OPN levels were measured by ELISA in 98 patients with RA and 98 healthy controls.Serum RF was detected by nephelometric immunoassay.Results The serum HC gP39,OPN and RF levels of RA group were significantly higher than the healthy control group (t =20.25,32.71,36.34,all P ＜ 0.01),and serum HC gP39,OPN and RF levels in active phase patients were higher than the inactive phase patients (t =24.22,45.62,50.15,all P ＜0.01).The levels of serum HC gP39,OPN increased gradually with the increase of the staging severity(F =18.48,12.36,all P ＜0.05).The serum level of RF was positively correlated with the levels of HC gP39,OPN in patients with RA (r =0.682,0.656,all P ＜ 0.01),the serum level of HC gP39 was positively correlated with the level of OPN (r =0.608,P ＜ 0.01).Conclusion The HC gP39,OPN and RF reflect situation of RA patients and have close relationship with the clinical progression of RA,which can be used as one of important indexes to judge RA activity and different staging.
