中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
15期
2281-2283
,共3页
脑梗死%阿托伐他汀%同型半胱氨酸%基质金属蛋白酶-9
腦梗死%阿託伐他汀%同型半胱氨痠%基質金屬蛋白酶-9
뇌경사%아탁벌타정%동형반광안산%기질금속단백매-9
Cerebral infarction%Atorvastatin%Homocysteine%Matrix metalloproteinase-9
目的 观察不同剂量阿托伐他汀对急性脑梗死患者血同型半胱氨酸(Hcy)和基质金属蛋白酶-9 (MMP-9)的影响.方法 将90例急性脑梗死患者采用随机数字表法分为观察组、对照组各45例,观察组在常规治疗基础上加用阿托伐他汀40 mg/d,对照组在常规治疗基础上加用阿托伐他汀20 mg/d,治疗1月后观察疗效.治疗前后测定患者血Hcy和MMP-9.结果 观察组有效率为95.6％,对照组有效率为86.7％,两组差异有统计学意义(x2 =2.1951,P＜0.05).两组治疗后血Hcy和MMP-9均较治疗前有明显降低,并且治疗后两组差异亦有统计学意义(均P＜0.05).结论 大剂量阿托伐他汀可以通过更明显降低Hcy和MMP-9而改善病情
目的 觀察不同劑量阿託伐他汀對急性腦梗死患者血同型半胱氨痠(Hcy)和基質金屬蛋白酶-9 (MMP-9)的影響.方法 將90例急性腦梗死患者採用隨機數字錶法分為觀察組、對照組各45例,觀察組在常規治療基礎上加用阿託伐他汀40 mg/d,對照組在常規治療基礎上加用阿託伐他汀20 mg/d,治療1月後觀察療效.治療前後測定患者血Hcy和MMP-9.結果 觀察組有效率為95.6％,對照組有效率為86.7％,兩組差異有統計學意義(x2 =2.1951,P＜0.05).兩組治療後血Hcy和MMP-9均較治療前有明顯降低,併且治療後兩組差異亦有統計學意義(均P＜0.05).結論 大劑量阿託伐他汀可以通過更明顯降低Hcy和MMP-9而改善病情
목적 관찰불동제량아탁벌타정대급성뇌경사환자혈동형반광안산(Hcy)화기질금속단백매-9 (MMP-9)적영향.방법 장90례급성뇌경사환자채용수궤수자표법분위관찰조、대조조각45례,관찰조재상규치료기출상가용아탁벌타정40 mg/d,대조조재상규치료기출상가용아탁벌타정20 mg/d,치료1월후관찰료효.치료전후측정환자혈Hcy화MMP-9.결과 관찰조유효솔위95.6％,대조조유효솔위86.7％,량조차이유통계학의의(x2 =2.1951,P＜0.05).량조치료후혈Hcy화MMP-9균교치료전유명현강저,병차치료후량조차이역유통계학의의(균P＜0.05).결론 대제량아탁벌타정가이통과경명현강저Hcy화MMP-9이개선병정
Objective To study the effects of different doses of atorvastatin on serum homocysteine (Hcy) and matrix metallopmteinase-9 (MMP-9) in patients with acute cerebral infarction.Methods Ninety-patients with acute cerebral infarction were randomly divided into two groups,the observation group (n =45 cases) and the control group(n =45 cases).The patients in the observation group were treated by the conventional therapy plus atorvastatin 40mg/d,while the patients in the control group were treated by the conventional therapy plus atorvastatin 20mg/d.Hcy and MMP-9 were detected before and after treatment for one month.Results The total effective rate was 95.6％in the observation group and 86.7％ in the control group.There was significant difference between two groups(x2 =2.1951,P ＜ 0.05).Hcy and MMP-9 were decreased after treatment in both groups and those in the observation group were lower than in the control group (all P ＜ 0.05).Conclusion High-dose atorvastatin can improve patients with acute cerebral infarction through decreasing Hcy and MMP-9.
