中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
15期
2288-2289
,共2页
他汀类药物%肝损害,药物性%危险因素
他汀類藥物%肝損害,藥物性%危險因素
타정류약물%간손해,약물성%위험인소
Statins%Liver injury,drug-induced%Risk factors
目的 分析他汀类药物所致肝损害的特点及危险因素,为预防提供依据.方法 收集应用他汀类药物患者401例,出现肝损害者64例,分析临床特点并对相关因素如年龄、性别、饮酒、乙肝表面抗原携带者等进行统计学分析.结果 401例患者中,15.96％发生肝损害,其中HBsAg(+)、每周饮酒≥500 g、多次服用、≥60岁高龄者肝损害的发生率分别为41.07％、25.68％、19.67％、26.97％(均P＜0.05)；而性别与药物性肝损害无相关性(P＞0.05).结论 HBsAg(+)、饮酒、多次服用及老年人是发生肝损害高危人群,应引起临床重视.
目的 分析他汀類藥物所緻肝損害的特點及危險因素,為預防提供依據.方法 收集應用他汀類藥物患者401例,齣現肝損害者64例,分析臨床特點併對相關因素如年齡、性彆、飲酒、乙肝錶麵抗原攜帶者等進行統計學分析.結果 401例患者中,15.96％髮生肝損害,其中HBsAg(+)、每週飲酒≥500 g、多次服用、≥60歲高齡者肝損害的髮生率分彆為41.07％、25.68％、19.67％、26.97％(均P＜0.05)；而性彆與藥物性肝損害無相關性(P＞0.05).結論 HBsAg(+)、飲酒、多次服用及老年人是髮生肝損害高危人群,應引起臨床重視.
목적 분석타정류약물소치간손해적특점급위험인소,위예방제공의거.방법 수집응용타정류약물환자401례,출현간손해자64례,분석림상특점병대상관인소여년령、성별、음주、을간표면항원휴대자등진행통계학분석.결과 401례환자중,15.96％발생간손해,기중HBsAg(+)、매주음주≥500 g、다차복용、≥60세고령자간손해적발생솔분별위41.07％、25.68％、19.67％、26.97％(균P＜0.05)；이성별여약물성간손해무상관성(P＞0.05).결론 HBsAg(+)、음주、다차복용급노년인시발생간손해고위인군,응인기림상중시.
Objective To analyze the characteristics and risk factors of hepatic lesion caused by statins drugs,and to provide evidence for prevention.Methods 401 patients using statins were collected,64 cases occurred liver damage.Clinical features and related factors such as age,sex,alcohol,TB category,hepatitis B surface antigen carriers were statistically analyzed.Results In 401 cases,15.96％ of patients occurred liver damage.Statistical analysis showed that the incidence rates of liver function damage in HBsAg (+),weekly drinking ≥ 500g,retreatment,≥60 years old were 41.07％,25.68％,19.67％,26.97％ respectively(all P ＜ 0.05).Sex was not relate with drug induced liver damage(P ＞ 0.05).Conclusion HBsAg(+),alcohol consumption,the retreatment and old TB patients are high-risk groups occurred hepatic dysfunction,which should attract clinical attention.
