中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
17期
2561-2563
,共3页
许国斌%张近波%董美平%朱金强%史朝红%鄢来超%曹烈祥%吴仙丹
許國斌%張近波%董美平%硃金彊%史朝紅%鄢來超%曹烈祥%吳仙丹
허국빈%장근파%동미평%주금강%사조홍%언래초%조렬상%오선단
连续性肾替代治疗%胰腺炎,急性坏死性
連續性腎替代治療%胰腺炎,急性壞死性
련속성신체대치료%이선염,급성배사성
Continuous renal replacement therapy%Pancreatitis,acute necrosis
目的 研究连续性肾脏替代疗法(CRRT)对重症急性胰腺炎(SAP)患者的治疗效果.方法 按照平行对照设计原理,将70例患者按数字表法随机分为对照组35例和CRRT组35例,对照组采用常规治疗,CRRT组在常规治疗基础上行CRRT治疗,比较两组临床疗效.结果 两组治疗前急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)评分、C反应蛋白(CRP)水平差异均无统计学意义；治疗后对照组、CRRT组A-PACHEⅡ评分分别为(16.85±2.01)分、(11.52 ±1.85)分,两组差异有统计学意义(t=2.176,P＜0.05)；CRP水平分别为(23.77±4.15) mg/L、(11.98±2.04) mg/L,两组差异有统计学意义(t=2.793,P＜0.01)；对照组、CRRT组ICU住院时间分别为(19.92 ±2.28)d、(12.73±1.95)d,两组差异有统计学意义(t=2.313,P＜0.05)；对照组病死率为45.1％,高于CRRT组的14.3％(x2=7.000,P＜0.01).结论 在常规治疗基础上早期行CRRT治疗,能降低SAP患者的ICU住院时间,降低病死率.
目的 研究連續性腎髒替代療法(CRRT)對重癥急性胰腺炎(SAP)患者的治療效果.方法 按照平行對照設計原理,將70例患者按數字錶法隨機分為對照組35例和CRRT組35例,對照組採用常規治療,CRRT組在常規治療基礎上行CRRT治療,比較兩組臨床療效.結果 兩組治療前急性生理學及慢性健康狀況評分Ⅱ(APACHEⅡ)評分、C反應蛋白(CRP)水平差異均無統計學意義；治療後對照組、CRRT組A-PACHEⅡ評分分彆為(16.85±2.01)分、(11.52 ±1.85)分,兩組差異有統計學意義(t=2.176,P＜0.05)；CRP水平分彆為(23.77±4.15) mg/L、(11.98±2.04) mg/L,兩組差異有統計學意義(t=2.793,P＜0.01)；對照組、CRRT組ICU住院時間分彆為(19.92 ±2.28)d、(12.73±1.95)d,兩組差異有統計學意義(t=2.313,P＜0.05)；對照組病死率為45.1％,高于CRRT組的14.3％(x2=7.000,P＜0.01).結論 在常規治療基礎上早期行CRRT治療,能降低SAP患者的ICU住院時間,降低病死率.
목적 연구련속성신장체대요법(CRRT)대중증급성이선염(SAP)환자적치료효과.방법 안조평행대조설계원리,장70례환자안수자표법수궤분위대조조35례화CRRT조35례,대조조채용상규치료,CRRT조재상규치료기출상행CRRT치료,비교량조림상료효.결과 량조치료전급성생이학급만성건강상황평분Ⅱ(APACHEⅡ)평분、C반응단백(CRP)수평차이균무통계학의의；치료후대조조、CRRT조A-PACHEⅡ평분분별위(16.85±2.01)분、(11.52 ±1.85)분,량조차이유통계학의의(t=2.176,P＜0.05)；CRP수평분별위(23.77±4.15) mg/L、(11.98±2.04) mg/L,량조차이유통계학의의(t=2.793,P＜0.01)；대조조、CRRT조ICU주원시간분별위(19.92 ±2.28)d、(12.73±1.95)d,량조차이유통계학의의(t=2.313,P＜0.05)；대조조병사솔위45.1％,고우CRRT조적14.3％(x2=7.000,P＜0.01).결론 재상규치료기출상조기행CRRT치료,능강저SAP환자적ICU주원시간,강저병사솔.
Objective To investigate the effect of continuous renal replacement therapy(CRRT) on severe acute pancreatitis(SAP).Methods 70 patients with SAP were collected and divided into the control group and CRRT treatment group.The clinical data and the score of APACHE Ⅱ were compared between the two groups.Results There were no significant differences between control group and CRRT treatment group in APACHE Ⅱ score,C-reactive protein(CRP) before treatment(P ＞ 0.05).After treatment,the score of APACHE Ⅱ was significantly lower in CRRT treatment group than that in control group[(11.52 ± 1.85) points vs (16.85 ± 2.01) points,t =2.176,P ＜0.05],the level of CRP was significantly lower in CRRT treatment group than that in control group[(11.98 ±2.04)ng/L vs (23.77 ± 4.15)ng/L,t =2.793,P ＜ 0.01] ;the hospitalizing time was significantly lower in CRRT treatment group than that in control group[(12.73 ± 1.95)d vs (19.92 ±2.28)d,t =2.313,P ＜0.05],the mortality rate was significantly lower in CRRT treatment group than that in control group(14.3％ vs 45.1％,x2 =7.000,P ＜ 0.01).Conclusion CRRT could decrease both the hospitalizing time and mortality in SAP patients based on traditional treatment.
