CAJ | 학술논문

目的评估静脉注射用丙种球蛋白(IVIG)治疗重症EV71感染手足口病患儿的疗效.方法回顾性分析重症EV71感染手足口病患儿的临床资料,按收治时间及治疗原则不同分为2010年组及2012年组,2010年组患儿常规应用MG治疗,2012年组患儿仅对有发展成危重症可能的患儿应用MG,比较两组患儿的显效率、有效率、无效率、危重症发生率及病死率.结果两组患儿显效率(86.0％与85.2％)、有效率(9.6％与11.8％)、无效率(4.4％与3.0％)、危重症发生率(4.0％与2.2％)差异均无统计学意义(x2=0.011、1.269、1.657、3.304,均P＞0.05)；2010年组病死率(2.8％)高于2012年组(0.6％)(x2=8.213,P＜0.05).结论 IVIG在治疗重症EV71感染手足口病患儿中无优势,不建议使用.
목적 평고정맥주사용병충구단백(IVIG)치료중증EV71감염수족구병환인적료효.방법 회고성분석중증EV71감염수족구병환인적림상자료,안수치시간급치료원칙불동분위2010년조급2012년조,2010년조환인상규응용MG치료,2012년조환인부대유발전성위중증가능적환인응용MG,비교량조환인적현효솔、유효솔、무효솔、위중증발생솔급병사솔.결과 량조환인현효솔(86.0％여85.2％)、유효솔(9.6％여11.8％)、무효솔(4.4％여3.0％)、위중증발생솔(4.0％여2.2％)차이균무통계학의의(x2=0.011、1.269、1.657、3.304,균P＞0.05)；2010년조병사솔(2.8％)고우2012년조(0.6％)(x2=8.213,P＜0.05).결론 IVIG재치료중증EV71감염수족구병환인중무우세,불건의사용.
Objective To evaluate the efficacy of intravenous immunoglobulin (IVIG) in the treatment of severe EV71 infection in children.Methods The clinical data of children with severe EV71 infection,who admitted in our hospital from January 2010 to November 2012 were retrospectively analyzed.According to the time of admission and treatment principles,the patients were divided into the 2010 group and the 2012 group.The patients of the 2010 group routinely received IVIG treatment,but patients in the 2012 group received IVIG treatment in serious condition.The obvious effective rate,effective rate,ineffective rate,the incidence rate of critically ill and mortality of the two groups were compared.Results There were no significant differences in the obvious effective rate (86.0％ and 85.2％),effective rate (9.6％ and 11.8％),ineffective rate (4.4％ and 3.0％),the incidence rate of critically ill (4.0％ and 2.2％) between the two groups (x2 =0.011,1.269,1.657,3.304,all P ＞ 0.05).The mortality of the 2010 group (2.8％) was higher than that of the 2012 group (0.6％)(x2 =8.213,P ＜0.05).Conclusion IVIG has no effect on patients with severe EV71 infection,and is not recommended.