中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
17期
2587-2589
,共3页
N-三甲基壳聚糖%甲氧沙林脂质体凝胶%透皮促进作用
N-三甲基殼聚糖%甲氧沙林脂質體凝膠%透皮促進作用
N-삼갑기각취당%갑양사림지질체응효%투피촉진작용
N-trimethyl chitosan%8-methoxypsoralen-loaded liposomal gels%Transdermal enhancement
目的 观察N-三甲基壳聚糖(TMC)对药物初级制剂凝胶的透皮吸收促进作用.方法 以季铵化程度为60％的TMC(TMC60)为促渗剂,加入到甲氧沙林脂质体(LMOP)凝胶中或对LMOP进行包衣处理,再制备成凝胶.采用Franz扩散池,以不含促渗剂的LMOP凝胶为阴性对照,1％氮酮+丙二醇为促渗剂的LMOP凝胶为阳性对照,考察游离TMC及TMC包衣对LMOP凝胶的体外透皮促进作用.结果 三种含促渗剂的LMOP凝胶与阴性对照相比,透皮效果及24h后皮肤蓄积量差异均有统计学意义(x2=8.65,P＜0.05),且以游离的TMC60促渗作用最优.结论 TMC可促进LMOP凝胶的体外透皮吸收,值得进一步研究.
目的 觀察N-三甲基殼聚糖(TMC)對藥物初級製劑凝膠的透皮吸收促進作用.方法 以季銨化程度為60％的TMC(TMC60)為促滲劑,加入到甲氧沙林脂質體(LMOP)凝膠中或對LMOP進行包衣處理,再製備成凝膠.採用Franz擴散池,以不含促滲劑的LMOP凝膠為陰性對照,1％氮酮+丙二醇為促滲劑的LMOP凝膠為暘性對照,攷察遊離TMC及TMC包衣對LMOP凝膠的體外透皮促進作用.結果 三種含促滲劑的LMOP凝膠與陰性對照相比,透皮效果及24h後皮膚蓄積量差異均有統計學意義(x2=8.65,P＜0.05),且以遊離的TMC60促滲作用最優.結論 TMC可促進LMOP凝膠的體外透皮吸收,值得進一步研究.
목적 관찰N-삼갑기각취당(TMC)대약물초급제제응효적투피흡수촉진작용.방법 이계안화정도위60％적TMC(TMC60)위촉삼제,가입도갑양사림지질체(LMOP)응효중혹대LMOP진행포의처리,재제비성응효.채용Franz확산지,이불함촉삼제적LMOP응효위음성대조,1％담동+병이순위촉삼제적LMOP응효위양성대조,고찰유리TMC급TMC포의대LMOP응효적체외투피촉진작용.결과 삼충함촉삼제적LMOP응효여음성대조상비,투피효과급24h후피부축적량차이균유통계학의의(x2=8.65,P＜0.05),차이유리적TMC60촉삼작용최우.결론 TMC가촉진LMOP응효적체외투피흡수,치득진일보연구.
Objective To explore the enhancement effect of N-trimethyl chitosan(TMC) on transdermal absorption of 8-methoxypsoralen-loaded liposomal(LMOP) gels in vitro.Methods TMC with quaternization degree of 60％ (TMC60) as the enhancer,the LMOP gels were prepared with free TMC60 or TMC60-coating.The enhancement of free TMC60 or TMC60-coating was studied by using Franz diffusion,cells with LMOP gels as the negative control and LMOP gels including 1％ Azone + propylene glycol as the positive control.Results Compared with the negative control,enhancement and drug amount in skin of LMOP gels with enhancer all showed significant difference (x2 =8.65,P ＜ 0.05),and the free TMC.60 was the best.Conclusion TMC can enhance the transdermal penetration of LMOP gels in vitro and is valuable to be studied further.
