中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
19期
2960-2962
,共3页
糖尿病,2型%甘精胰岛素%阿卡波糖%血糖%胰岛β细胞
糖尿病,2型%甘精胰島素%阿卡波糖%血糖%胰島β細胞
당뇨병,2형%감정이도소%아잡파당%혈당%이도β세포
Diabetes mellitus,2 type%Insulin glargine%Blood sugar%Pancreaticβ cell
目的 探讨甘精胰岛素联合阿卡波糖对2型糖尿病患者血糖达标率及胰岛β细胞功能的影响.方法 选择2型糖尿病患者70例,按就诊病历号顺序随机分为观察组与对照组.两组患者均予以饮食控制和体育锻炼等基础治疗.观察组在此基础上予以甘精胰岛素联合阿卡波糖治疗,对照组在此基础上予以精蛋白生物合成人胰岛素(预混胰岛素诺和灵30R)治疗,两组疗程均为8周.结果 治疗8周后,观察组患者空腹血糖、餐后2h血糖和糖化血红蛋白的达标率(95.0％、85.0％和77.5％)明显高于对照组(77.5％、62.5％和55.0％)(x2=5.16、5.23和4.53,均P＜0.05)；两组患者空腹C肽及餐后C肽水平均较前明显上升(t=2.43、2.32、2.28、2.19,均P＜0.05),且观察组上升幅度与对照组比较更明显(t=2.17、2.13,均P＜0.05).观察组治疗期间低血糖事件的发生率明显低于对照组(x2 =4.11,P＜0.05).结论 甘精胰岛素联合阿卡波糖治疗2型糖尿病有利于患者的血糖及糖化血红蛋白的达标,减少低血糖事件发生率；同时能更好地保护与改善胰岛β细胞功能,延缓患者减少急慢性并发症的发生和发展.
目的 探討甘精胰島素聯閤阿卡波糖對2型糖尿病患者血糖達標率及胰島β細胞功能的影響.方法 選擇2型糖尿病患者70例,按就診病歷號順序隨機分為觀察組與對照組.兩組患者均予以飲食控製和體育鍛煉等基礎治療.觀察組在此基礎上予以甘精胰島素聯閤阿卡波糖治療,對照組在此基礎上予以精蛋白生物閤成人胰島素(預混胰島素諾和靈30R)治療,兩組療程均為8週.結果 治療8週後,觀察組患者空腹血糖、餐後2h血糖和糖化血紅蛋白的達標率(95.0％、85.0％和77.5％)明顯高于對照組(77.5％、62.5％和55.0％)(x2=5.16、5.23和4.53,均P＜0.05)；兩組患者空腹C肽及餐後C肽水平均較前明顯上升(t=2.43、2.32、2.28、2.19,均P＜0.05),且觀察組上升幅度與對照組比較更明顯(t=2.17、2.13,均P＜0.05).觀察組治療期間低血糖事件的髮生率明顯低于對照組(x2 =4.11,P＜0.05).結論 甘精胰島素聯閤阿卡波糖治療2型糖尿病有利于患者的血糖及糖化血紅蛋白的達標,減少低血糖事件髮生率；同時能更好地保護與改善胰島β細胞功能,延緩患者減少急慢性併髮癥的髮生和髮展.
목적 탐토감정이도소연합아잡파당대2형당뇨병환자혈당체표솔급이도β세포공능적영향.방법 선택2형당뇨병환자70례,안취진병력호순서수궤분위관찰조여대조조.량조환자균여이음식공제화체육단련등기출치료.관찰조재차기출상여이감정이도소연합아잡파당치료,대조조재차기출상여이정단백생물합성인이도소(예혼이도소낙화령30R)치료,량조료정균위8주.결과 치료8주후,관찰조환자공복혈당、찬후2h혈당화당화혈홍단백적체표솔(95.0％、85.0％화77.5％)명현고우대조조(77.5％、62.5％화55.0％)(x2=5.16、5.23화4.53,균P＜0.05)；량조환자공복C태급찬후C태수평균교전명현상승(t=2.43、2.32、2.28、2.19,균P＜0.05),차관찰조상승폭도여대조조비교경명현(t=2.17、2.13,균P＜0.05).관찰조치료기간저혈당사건적발생솔명현저우대조조(x2 =4.11,P＜0.05).결론 감정이도소연합아잡파당치료2형당뇨병유리우환자적혈당급당화혈홍단백적체표,감소저혈당사건발생솔；동시능경호지보호여개선이도β세포공능,연완환자감소급만성병발증적발생화발전.
Objective To explore the effect of insulin glargine combined with carbose onblood glucose attaining standard and pancreatic β cell function of type 2 diabetic patients.Methods 70 type 2 diabetic patients were divided into observation group and control group.All the patients got fundamental treatment as diet control and physical exercise.Patients of observing group got extra treatment as using insulin glargine combined with carbose,while patients of control group got extra treatment as using premixed insulin 30R(isophane protamine biosynthetic human insulin),all the treatment lasted for 8 weeks.Results 8 weeks after treatment,the rate of reaching standard of FBG and 2h postprandial plasma glucose and glycosylated hemoglobin (95.0％,85.0％ and 77.5％) of observing group were significantly higher than those of control group (77.5％,62.5％ and 55.0％) (x2 =5.16,5.23 and 4.53,all P ＜0.05).The levels of FCP and PCP increased significantly in both groups than that of before treatment (t =2.43,2.32,2.28,2.19,all P ＜ 0.05),and the change of observation group was more obviously than that of control group (t =2.17,2.13,all P ＜ 0.05).The occurrence rate of hypoglycemia of observation group was significantly lower than that of control group(x2 =4.11,P ＜0.05).Conclusion Treating diabetic patient by insulin glargine combined with acarbose has high safety,and helps to reach the standard of FBG and glycosylated hemoglobin,reduce the incurrence rate of hypoglycemia,protect and improve the function of pancreatic 3 cell,and postpone the beginning and progress of complication.
