CAJ | 학술논문

目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)联合重组人干扰素α-2b凝胶治疗肛肠内多发性尖锐湿疣的疗效.方法 95例男性舡肠内尖锐湿疣患者按数字表法随机分为两组:治疗组50例,对照组45例.治疗组采用ALA-PDT联合重组人干扰素α-2 b凝胶外用治疗,每7～10天做1次ALA-PDT治疗,期间使用重组人干扰素α-2b凝胶外用；对照组仅采用ALA-PDT治疗.治疗l～3次后判断临床效果.对完全缓解的病例追加治疗1次,对部分缓解的患者继续治疗,直至症状完全缓解再追加治疗1次为止.在治疗结束后每月随访1次,共随访3次,观察皮疹复发情况、不良反应及患者对治疗的评价.结果治疗组痊愈率94.0％ (47/50),有效率98.0％ (49/50),对照组痊愈率88.9％(40/45),有效率91.1％ (41/45),两组治疗后痊愈率差异无统计学意义(x2 =0.290,P＞0.05).治疗组复发率2.0％ (1/50),对照组复发率13.3％ (6/45),两组差异有统计学意义(x2 =4.457,P=0.035).两组患者治疗后均无明显不良反应.结论 ALA-PDT联合重组人干扰素α-2b凝胶治疗肛肠内多发性尖锐湿疣安全、有效、复发率低.
목적 관찰5-안기동무산광동력요법(ALA-PDT)연합중조인간우소α-2b응효치료항장내다발성첨예습우적료효.방법 95례남성강장내첨예습우환자안수자표법수궤분위량조:치료조50례,대조조45례.치료조채용ALA-PDT연합중조인간우소α-2 b응효외용치료,매7～10천주1차ALA-PDT치료,기간사용중조인간우소α-2b응효외용；대조조부채용ALA-PDT치료.치료l～3차후판단림상효과.대완전완해적병례추가치료1차,대부분완해적환자계속치료,직지증상완전완해재추가치료1차위지.재치료결속후매월수방1차,공수방3차,관찰피진복발정황、불량반응급환자대치료적평개.결과 치료조전유솔94.0％ (47/50),유효솔98.0％ (49/50),대조조전유솔88.9％(40/45),유효솔91.1％ (41/45),량조치료후전유솔차이무통계학의의(x2 =0.290,P＞0.05).치료조복발솔2.0％ (1/50),대조조복발솔13.3％ (6/45),량조차이유통계학의의(x2 =4.457,P=0.035).량조환자치료후균무명현불량반응.결론 ALA-PDT연합중조인간우소α-2b응효치료항장내다발성첨예습우안전、유효、복발솔저.
Objective To investigate the clinical efficacy and safety of 5-aminolaevulinic acid-photodynamic therapy(ALA-PDT) in treatment of anorectal condyloma acuminatum.Methods 95 cases who suffered from male multiple condyloma acuminatum were randomly divided into two groups.There were 50 cases in the treatment group and 45 cases in the control group.There were no statistically significant between two groups in age,sex,course of disease,skin lesions,the size and the distribution.The treatment group was treated by photodynamic therapy combined with recombinant human interferon α-2b Gel while the control group was treated only by photodynamic therapy.The treatment time lasted 7-10 days later if the Lesion was not completely removed.Totally,1-4 treatment sessions were given.Then the rate of recovery and recurernce of the two groups were compared.Results The recovery rate in treatment group was 94.0％ (47/50) and 88.9％ (40/45) were found in control group.There were no significant difference in the two groups (x2 =0.290,P ＞ 0.05) ;The recurernce rate of the treatment group was 2.0％ (1/50) and the control group was 13.3％ (6/45),the two groups had significant differences (x2 =4.457,P =0.035).Conclusion ALA-PDT combined with recombinant human interferon α-2b Gel in the topical treatment of anorectal condyloma acuminatum is safe and effective,whcih may serve a therapeutic option for anorectal condyloma acuminatum.