中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
20期
3041-3044
,共4页
袁双凤%汤庆娅%马淑焕%时艳丽%陈爱民%马海秀%孙亚娟%邵彩红%孙燕
袁雙鳳%湯慶婭%馬淑煥%時豔麗%陳愛民%馬海秀%孫亞娟%邵綵紅%孫燕
원쌍봉%탕경아%마숙환%시염려%진애민%마해수%손아연%소채홍%손연
获得性免疫缺陷综合征%肠道营养%谷氨酰胺%T淋巴细胞%儿童
穫得性免疫缺陷綜閤徵%腸道營養%穀氨酰胺%T淋巴細胞%兒童
획득성면역결함종합정%장도영양%곡안선알%T림파세포%인동
Acquired immunodeficiency syndrome%Enteral nutrition%Glutamine%T-Lymphocytes%Child
目的 观察谷氨酰胺(Gln)强化的肠内营养干预对艾滋病患儿营养状况和T淋巴细胞免疫功能的影响.方法 将符合纳入标准的60例艾滋病患儿用随机数字表随机纳入观察组(Gln强化组30例)与对照组(常规型肠内营养组30例).干预前和干预第28天分别检测两组患儿营养相关指标、细胞免疫指标及血清Gln浓度变化.结果 干预第28天观察组患儿的外固血总淋巴细胞计数(TLC)[(2.81 ±0.25)×109/L比(2.53±0.24)×109/L]、血清Gln水平[(7.2±2.1) μmol/L比(5.5±1.2) μmol/L]较对照组升高明显(P＜0.05)；观察组血清白蛋白(ALB)[(40.5±3.1)g/L比(38.6±2.1)g/L]、CD4+百分比[(39.0±7.5)％比(35.3±9.9)％]、CD;/CD;比值[(1.6±0.8)比(1.2±0.6)]明显高于对照组(P＜0.01)；观察组胃肠道并发症的发生率也较对照组低(16.7％比40.0％,P＜0.01).结论 强化肠内营养干预能改善艾滋病患儿营养状况,提高其T淋巴细胞免疫水平,降低胃肠道并发症发生率,值得临床应用推广.
目的 觀察穀氨酰胺(Gln)彊化的腸內營養榦預對艾滋病患兒營養狀況和T淋巴細胞免疫功能的影響.方法 將符閤納入標準的60例艾滋病患兒用隨機數字錶隨機納入觀察組(Gln彊化組30例)與對照組(常規型腸內營養組30例).榦預前和榦預第28天分彆檢測兩組患兒營養相關指標、細胞免疫指標及血清Gln濃度變化.結果 榦預第28天觀察組患兒的外固血總淋巴細胞計數(TLC)[(2.81 ±0.25)×109/L比(2.53±0.24)×109/L]、血清Gln水平[(7.2±2.1) μmol/L比(5.5±1.2) μmol/L]較對照組升高明顯(P＜0.05)；觀察組血清白蛋白(ALB)[(40.5±3.1)g/L比(38.6±2.1)g/L]、CD4+百分比[(39.0±7.5)％比(35.3±9.9)％]、CD;/CD;比值[(1.6±0.8)比(1.2±0.6)]明顯高于對照組(P＜0.01)；觀察組胃腸道併髮癥的髮生率也較對照組低(16.7％比40.0％,P＜0.01).結論 彊化腸內營養榦預能改善艾滋病患兒營養狀況,提高其T淋巴細胞免疫水平,降低胃腸道併髮癥髮生率,值得臨床應用推廣.
목적 관찰곡안선알(Gln)강화적장내영양간예대애자병환인영양상황화T림파세포면역공능적영향.방법 장부합납입표준적60례애자병환인용수궤수자표수궤납입관찰조(Gln강화조30례)여대조조(상규형장내영양조30례).간예전화간예제28천분별검측량조환인영양상관지표、세포면역지표급혈청Gln농도변화.결과 간예제28천관찰조환인적외고혈총림파세포계수(TLC)[(2.81 ±0.25)×109/L비(2.53±0.24)×109/L]、혈청Gln수평[(7.2±2.1) μmol/L비(5.5±1.2) μmol/L]교대조조승고명현(P＜0.05)；관찰조혈청백단백(ALB)[(40.5±3.1)g/L비(38.6±2.1)g/L]、CD4+백분비[(39.0±7.5)％비(35.3±9.9)％]、CD;/CD;비치[(1.6±0.8)비(1.2±0.6)]명현고우대조조(P＜0.01)；관찰조위장도병발증적발생솔야교대조조저(16.7％비40.0％,P＜0.01).결론 강화장내영양간예능개선애자병환인영양상황,제고기T림파세포면역수평,강저위장도병발증발생솔,치득림상응용추엄.
Objective To investigate the effect of enhanced glutamine (Gln) enteral nutrition intervention on the nutrition status and T lymphocytes-mediated immune function in children with HIV/AIDS.Methods According to the inclusion criteria,60 children with AIDS were randomly divided into observation group(Gln improved group 30 cases) and control group (conventional enteral nutrition group 30 cases).Before intervention and 28 days after intervention,the nutrition related index,index of cellular immunity and serum Gln changes were detected in two groups.Results In the observation group 28 days after intervention,the TLC and serum level of Gln was (2.81 ± 0.25) ×109/L,(7.2 ±2.1) μmol/L,which were significantly higher than those in the control group (2.53 ±0.24) × 109/L,(5.5 ± 1.2) μmol/L (P ＜ 0.05).In observation group,ALB was (40.5 ± 3.1) g/L,the percentage of CD4+ was (39.0 ± 7.5) ％,CD4+/CD8+ ratio was (1.6 ± 0.8),which were significantly higher than those in the control group (38.6 ± 2.1) g/L,(35.3 ± 9.9) ％,(1.2 ± 0.6) (P ＜ 0.01).Observation group had lower incidence rate of gastrointestinal complications (16.7％ vs 40.0％,P ＜ 0.01).Conclusion Enhanced enteral nutrition intervention can improve nutritional status in children with HIV/AIDS,raise the level of T lymphocyte immunity,reduce the incidence of gastrointestinal complications,which was worthy of clinical promotion.
