中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
20期
3067-3069
,共3页
脑梗死%奥拉西坦%神经生长因子%磷脂酶A%S100蛋白质类
腦梗死%奧拉西坦%神經生長因子%燐脂酶A%S100蛋白質類
뇌경사%오랍서탄%신경생장인자%린지매A%S100단백질류
Cerebral infarction%Oxiracetam%Nerve growth factor%Phospholipases A%S100 proteins
目的 探讨奥拉西坦联合鼠神经生长因子对急性脑梗死脂蛋白磷脂酶A2 (Lp-PLA2)和S100B蛋白的影响.方法 124例急性脑梗死患者按照数字表法分为两组,观察组62例,对照组62例,对照组采用常规治疗,观察组在常规治疗的基础上加用奥拉西坦和鼠神经生长因子治疗,共治疗21 d.测定患者血清Lp-PLA2和S100B蛋白.结果 观察组总有效率为98.4％,高于对照组的90.3％(x2=3.96,P＜0.05).两组治疗后患者血清Lp-PLA2和S100B蛋白均有明显降低,并且与对照组治疗后比较,观察组降低更明显(t=20.9091、3.7273,均P＜0.05).结论 奥拉西坦联合鼠神经生长因子可以减少急性脑梗死患者血清Lp-PLA2和S100B蛋白的表达.
目的 探討奧拉西坦聯閤鼠神經生長因子對急性腦梗死脂蛋白燐脂酶A2 (Lp-PLA2)和S100B蛋白的影響.方法 124例急性腦梗死患者按照數字錶法分為兩組,觀察組62例,對照組62例,對照組採用常規治療,觀察組在常規治療的基礎上加用奧拉西坦和鼠神經生長因子治療,共治療21 d.測定患者血清Lp-PLA2和S100B蛋白.結果 觀察組總有效率為98.4％,高于對照組的90.3％(x2=3.96,P＜0.05).兩組治療後患者血清Lp-PLA2和S100B蛋白均有明顯降低,併且與對照組治療後比較,觀察組降低更明顯(t=20.9091、3.7273,均P＜0.05).結論 奧拉西坦聯閤鼠神經生長因子可以減少急性腦梗死患者血清Lp-PLA2和S100B蛋白的錶達.
목적 탐토오랍서탄연합서신경생장인자대급성뇌경사지단백린지매A2 (Lp-PLA2)화S100B단백적영향.방법 124례급성뇌경사환자안조수자표법분위량조,관찰조62례,대조조62례,대조조채용상규치료,관찰조재상규치료적기출상가용오랍서탄화서신경생장인자치료,공치료21 d.측정환자혈청Lp-PLA2화S100B단백.결과 관찰조총유효솔위98.4％,고우대조조적90.3％(x2=3.96,P＜0.05).량조치료후환자혈청Lp-PLA2화S100B단백균유명현강저,병차여대조조치료후비교,관찰조강저경명현(t=20.9091、3.7273,균P＜0.05).결론 오랍서탄연합서신경생장인자가이감소급성뇌경사환자혈청Lp-PLA2화S100B단백적표체.
Objective To study the influence of oxiracetam plus mouse nerve growth factor(mNGF) on serum lysophosphatidic acid 2(Lp-PLA2) and S 100B protein in patients with acute cerebral infarction.Methods 124 patients with acute cerebral infarction were randomly divided into the observation group (n =62 cases) and the control group(n =62 cases).The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated by oxiracetam plus mNGF on the basis of conventional therapy.They were treated for 21 days.Serum Lp-PLA2 and S100B were detected.Results The total effective rate of the observation group was 98.4％,which was significantly higher than 90.3％ of the control group (x2 =3.96,P ＜ 0.05).Serum LpPLA2 and S100B were decreased in two groups after treatment.Serum Lp-PLA2 and S100B in the observation group were lower than those in the control group(t =20.9091,3.7273,all P ＜ 0.05).Conclusion Oxiracetam plus mNGF can decrease serum Lp-PLA2 and mNGF in patients with acute cerebral infarction.
