中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
20期
3083-3084
,共2页
拉米夫定%结核,肺%肝炎,乙型,慢性%治疗结果
拉米伕定%結覈,肺%肝炎,乙型,慢性%治療結果
랍미부정%결핵,폐%간염,을형,만성%치료결과
Lamivudine%Tuberculosis,pulmonary%Hepatitis B,chronic%Treatment outcome
目的 探讨拉米夫定治疗肺结核合并慢性乙型肝炎患者的临床疗效.方法 选择肺结核合并慢性乙型肝炎患者98例作为研究对象,按数字表法随机分为两组,对照组49例采用常规治疗措施,观察组49例在常规治疗基础上加用拉米夫定治疗,比较两组临床疗效及不良反应.结果 治疗过程中,观察组肝功能损害率为10.20％,明显低于对照组的18.37％(x2=4.21,P＜0.05)；在治疗后,观察组的肝功能相关指标以及HBV-DNA等均明显低于对照组(t=10.72、10.11、7.68,均P＜0.05).结论 拉米夫定治疗肺结核合并慢性乙型肝炎具有十分显著的疗效,有利于患者的早期恢复,值得临床广泛推广和应用.
目的 探討拉米伕定治療肺結覈閤併慢性乙型肝炎患者的臨床療效.方法 選擇肺結覈閤併慢性乙型肝炎患者98例作為研究對象,按數字錶法隨機分為兩組,對照組49例採用常規治療措施,觀察組49例在常規治療基礎上加用拉米伕定治療,比較兩組臨床療效及不良反應.結果 治療過程中,觀察組肝功能損害率為10.20％,明顯低于對照組的18.37％(x2=4.21,P＜0.05)；在治療後,觀察組的肝功能相關指標以及HBV-DNA等均明顯低于對照組(t=10.72、10.11、7.68,均P＜0.05).結論 拉米伕定治療肺結覈閤併慢性乙型肝炎具有十分顯著的療效,有利于患者的早期恢複,值得臨床廣汎推廣和應用.
목적 탐토랍미부정치료폐결핵합병만성을형간염환자적림상료효.방법 선택폐결핵합병만성을형간염환자98례작위연구대상,안수자표법수궤분위량조,대조조49례채용상규치료조시,관찰조49례재상규치료기출상가용랍미부정치료,비교량조림상료효급불량반응.결과 치료과정중,관찰조간공능손해솔위10.20％,명현저우대조조적18.37％(x2=4.21,P＜0.05)；재치료후,관찰조적간공능상관지표이급HBV-DNA등균명현저우대조조(t=10.72、10.11、7.68,균P＜0.05).결론 랍미부정치료폐결핵합병만성을형간염구유십분현저적료효,유리우환자적조기회복,치득림상엄범추엄화응용.
Objective To evaluate the clinical efficacy of lamivudine in the treatment of pulmonary tuberculosis patients with chronic hepatitis B.Methods 98 pulmonary tuberculosis patients with chronic hepatitis B were divided into two groups.49 patients in the control group were given conventional treatment,and 49 patients in the observation group received lamivudine on the basis of conventional treatment.The clinical efficacy and adverse reactions of two groups were compared.Results During treatment,the liver dysfunction rate of the observation group was 10.20％,which was significantly lower than 18.37％ of the control group(x2 =4.21,P ＜ 0.05).After treatment,the relevant indicators of liver function and HBV-DNA in the observation group were significantly lower than those in the control group(t =10.72,10.11,7.68,all P＜0.05).Conclusion Lamivudine in the treatment of pulmonary tuberculosis patients with chronic hepatitis B has significant effect,which is beneficial to the patients' early recovery,and it is worthy of extensive promotion and application.
