CAJ | 학술논문

目的探讨代谢综合征大鼠肝肾功能的变化和肾动脉形态结构的改变.方法分别用普通及高果糖饲料喂养大鼠(60只)10周,然后取血及解剖观察,了解大鼠肝肾功能和肾动脉形态结构的变化.结果对照组大鼠和MS组大鼠血清ALT、AST、UA、BUN、CR浓度随着喂养时间延长均有上升趋势,但MS组大鼠上升速度明显快于对照组大鼠,表现出肝肾功能损害,与临床上MS病例类似；与对照组相比较,MS组大鼠肾动脉内膜呈不均一增厚、结构紊乱,中膜平滑肌细胞向内膜增生,内弹力膜有不同程度破坏、断裂,中膜层弹力纤维增厚,结构紊乱,平滑肌细胞增生明显,内中膜明显增厚,出现了MS病例所呈现的病理改变.结论代谢综合征大鼠有轻度的肝肾功能损害,肾动脉内中膜有异常改变.
목적 탐토대사종합정대서간신공능적변화화신동맥형태결구적개변.방법 분별용보통급고과당사료위양대서(60지)10주,연후취혈급해부관찰,료해대서간신공능화신동맥형태결구적변화.결과 대조조대서화MS조대서혈청ALT、AST、UA、BUN、CR농도수착위양시간연장균유상승추세,단MS조대서상승속도명현쾌우대조조대서,표현출간신공능손해,여림상상MS병례유사；여대조조상비교,MS조대서신동맥내막정불균일증후、결구문란,중막평활기세포향내막증생,내탄력막유불동정도파배、단렬,중막층탄력섬유증후,결구문란,평활기세포증생명현,내중막명현증후,출현료MS병례소정현적병리개변.결론 대사종합정대서유경도적간신공능손해,신동맥내중막유이상개변.
Objective Toinvestigate the changes of liver and kidney function and morphology of the renal artery of the metabolic syndrome (MS) rats.Methods The rats were respectively fed with ordinary or high-fructose diet for 10 weeks,and then took the blood and anatomical observation,to explore the changes of liver and kidney function and morphology of the renal artery of the rats.Results The serum levels of ALT,AST,UA,BUN,CR in the control group and MS group were gradually increased with the feeding time.But those in MS rats were significantly increased than the control rats.MS rats showed dysfunction of liver and kidney,which similar to the clinical MS cases.Compared with the control group,the renal artery of MS rats had the same pathological changes as MS cases,presented with intima uneven thickening and structural disorder,medial smooth muscle cells hyperplasia to intimal,the internal elastic membrane with different degrees of damage and fracture,the film elastic fibers thickening and structural disorder,smooth muscle cell proliferation apparently,medial obvious thickening.Conclusion MS rats have mild dysfunction of liver and kidney and abnormal changes in intima and tunica media of renal artery.