中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
20期
3104-3106
,共3页
支气管哮喘%布地奈德%硫酸镁%免疫球蛋白E%白细胞介素-17
支氣管哮喘%佈地奈德%硫痠鎂%免疫毬蛋白E%白細胞介素-17
지기관효천%포지내덕%류산미%면역구단백E%백세포개소-17
Bronchial asthma%Budesonide%Magnesium sulfate%IgE%IL-17
目的 观察布地奈德联合硫酸镁对支气管哮喘急性期患儿血清免疫球蛋白E(IgE)和白细胞介素-17 (IL-17)的影响.方法 86例支气管哮喘急性发作患儿采用随机数字表法分为两组,观察组43例,对照组43例,对照组采用常规治疗加用静脉激素,观察组采用常规治疗加用雾化吸入布地奈德联合硫酸镁治疗,共治疗7d.测定患者血清IgE和IL-17.结果 治疗后观察组总有效率为97.7％,高于对照组的88.4％(x2=5.24,P＜0.01).两组治疗后患者血清IgE和IL-17均有明显降低(t=21.7119、13.0190、11.2647、7.1588,均P＜0.01),与对照组治疗后比较,观察组降低更明显(t=13.8141、5.1214,均P＜0.05).结论 布地奈德联合硫酸镁可以明显减少支气管哮喘急性发作患儿血清IgE和IL-17表达.
目的 觀察佈地奈德聯閤硫痠鎂對支氣管哮喘急性期患兒血清免疫毬蛋白E(IgE)和白細胞介素-17 (IL-17)的影響.方法 86例支氣管哮喘急性髮作患兒採用隨機數字錶法分為兩組,觀察組43例,對照組43例,對照組採用常規治療加用靜脈激素,觀察組採用常規治療加用霧化吸入佈地奈德聯閤硫痠鎂治療,共治療7d.測定患者血清IgE和IL-17.結果 治療後觀察組總有效率為97.7％,高于對照組的88.4％(x2=5.24,P＜0.01).兩組治療後患者血清IgE和IL-17均有明顯降低(t=21.7119、13.0190、11.2647、7.1588,均P＜0.01),與對照組治療後比較,觀察組降低更明顯(t=13.8141、5.1214,均P＜0.05).結論 佈地奈德聯閤硫痠鎂可以明顯減少支氣管哮喘急性髮作患兒血清IgE和IL-17錶達.
목적 관찰포지내덕연합류산미대지기관효천급성기환인혈청면역구단백E(IgE)화백세포개소-17 (IL-17)적영향.방법 86례지기관효천급성발작환인채용수궤수자표법분위량조,관찰조43례,대조조43례,대조조채용상규치료가용정맥격소,관찰조채용상규치료가용무화흡입포지내덕연합류산미치료,공치료7d.측정환자혈청IgE화IL-17.결과 치료후관찰조총유효솔위97.7％,고우대조조적88.4％(x2=5.24,P＜0.01).량조치료후환자혈청IgE화IL-17균유명현강저(t=21.7119、13.0190、11.2647、7.1588,균P＜0.01),여대조조치료후비교,관찰조강저경명현(t=13.8141、5.1214,균P＜0.05).결론 포지내덕연합류산미가이명현감소지기관효천급성발작환인혈청IgE화IL-17표체.
Objective To observe the effect of budesonide plus magnesium sulfate on serum IgE and interleukin-17 (IL-17) in children with acute bronchial asthma.Methods 86 children with acute bronchial asthma were randomly divided into the observation group (n =43 cases) and the control group (n =43 cases).The children in control group were treated through the conventional treatment plus intraveneous hormone,and the children in the observation group were treated through the conventional treatment plus budesonide and magnesium sulfate.They were treated for 7 days.Serum IgE and IL-17 were detected before and after treatment.Results The total effective rate of the observation group was 97.7 ％,which was significantly higher than 88.4％ of the control group (x2 =5.24,P ＜ 0.05).Serum IgE and IL-17 levels were decreased after treatment in both two groups (t =21.7119,13.0190,11.2647,7.1588,P ＜ 0.01),and compared with the control group,those in the observation group were significantly lower (t =13.8141,5.1214,all P ＜0.05).Conclusion Budesonide plus magnesium sulfate can significantly decrease serum IgE and IL-17 in children with acute bronchial asthma.
