中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
21期
3205-3207
,共3页
慢性精神分裂症%氯丙嗪%奥氮平%齐拉西酮%认知功能
慢性精神分裂癥%氯丙嗪%奧氮平%齊拉西酮%認知功能
만성정신분렬증%록병진%오담평%제랍서동%인지공능
Schizophrenia%Chlorpromazine%Olanzapine%Ziprasidone%Cognitive function
目的 比较氯丙嗪、奥氮平和齐拉西酮对慢性精神分裂症患者认知功能的影响.方法 将120例慢性精神分裂症患者按数字表法随机分为三组,分别为氯丙嗪组(38例)、奥氮平组(41例)和齐拉西酮组(41例),于入组前、治疗后第12周时采用简明精神病量表(BPRS)、个人和社会功能量表(PSP)、威斯康星卡片分类测验(WCST)、修订韦氏成人智力量表(WAIS-RC)进行随访评定.结果 经12周治疗,三组治疗前后BPRS测试结果差异均有统计学意义[F(5,41) =6.49,P＜0.05],而三组之间差异无统计学意义；第12周末,齐拉西酮组和奥氮平组WCST[F(5,47)=18.30,P＜0.05]、PSP[F(5,47)=10.02,P＜0.05]和WAIS-RC[F(5,47) =6.74,P ＜0.05]评分显著优于氯丙嗪组.结论 氯丙嗪、奥氮平和齐拉西酮均可改善慢性精神分裂症患者精神症状和认知功能,齐拉西酮和奥氮平对认知功能损害的改善效果优于氯丙嗪.
目的 比較氯丙嗪、奧氮平和齊拉西酮對慢性精神分裂癥患者認知功能的影響.方法 將120例慢性精神分裂癥患者按數字錶法隨機分為三組,分彆為氯丙嗪組(38例)、奧氮平組(41例)和齊拉西酮組(41例),于入組前、治療後第12週時採用簡明精神病量錶(BPRS)、箇人和社會功能量錶(PSP)、威斯康星卡片分類測驗(WCST)、脩訂韋氏成人智力量錶(WAIS-RC)進行隨訪評定.結果 經12週治療,三組治療前後BPRS測試結果差異均有統計學意義[F(5,41) =6.49,P＜0.05],而三組之間差異無統計學意義；第12週末,齊拉西酮組和奧氮平組WCST[F(5,47)=18.30,P＜0.05]、PSP[F(5,47)=10.02,P＜0.05]和WAIS-RC[F(5,47) =6.74,P ＜0.05]評分顯著優于氯丙嗪組.結論 氯丙嗪、奧氮平和齊拉西酮均可改善慢性精神分裂癥患者精神癥狀和認知功能,齊拉西酮和奧氮平對認知功能損害的改善效果優于氯丙嗪.
목적 비교록병진、오담평화제랍서동대만성정신분렬증환자인지공능적영향.방법 장120례만성정신분렬증환자안수자표법수궤분위삼조,분별위록병진조(38례)、오담평조(41례)화제랍서동조(41례),우입조전、치료후제12주시채용간명정신병량표(BPRS)、개인화사회공능량표(PSP)、위사강성잡편분류측험(WCST)、수정위씨성인지역량표(WAIS-RC)진행수방평정.결과 경12주치료,삼조치료전후BPRS측시결과차이균유통계학의의[F(5,41) =6.49,P＜0.05],이삼조지간차이무통계학의의；제12주말,제랍서동조화오담평조WCST[F(5,47)=18.30,P＜0.05]、PSP[F(5,47)=10.02,P＜0.05]화WAIS-RC[F(5,47) =6.74,P ＜0.05]평분현저우우록병진조.결론 록병진、오담평화제랍서동균가개선만성정신분렬증환자정신증상화인지공능,제랍서동화오담평대인지공능손해적개선효과우우록병진.
Objective To compare the effects of chlorpromazine,olanzapine and ziprasidone on cognitive function of patients with chronic schizophrenia.Methods A total of 120 patients with chronic schizophrenia were randomly divided into chlorpromazine group(n =38),olanzapine group(n =41) and ziprasidone group(n =41).The patients were subjected to the Brief Psychiatric Rating Scale(BPRS),Wisconsin Card Sorting Test(WCST),Personal and Social Function of Scale (PSP) and Wechsler Adult Intelligence Scale-Revised (WAIS-RC) assessment respectively,before and after treatment for 12 weeks.Results After treatment for 12 weeks,the score of BPRS significantly decreased in three groups compared with that before treatment [F (5,41) =6.49,P ＜ 0.05].After treatment for 12 weeks,the results of WCST [F (5,47) =18.30,P ＜ 0.05],PSP [F (5,47) =10.02,P ＜ 0.05] and WAIS-RC [F(5,47) =6.74,P ＜ 0.05] test in ziprasidone and olanzapine group were better than that of chlorpromazine group.Conclusion Chlorpromazine,olanzapine and ziprasidone could improve the cognitive function and mental syndrome of patients with chronic schizophrenia.In addition,the effect of ziprasidone and olanzapine was better than chlorpromazine.
