中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
21期
3280-3282
,共3页
呼吸道感染%儿童%羧甲淀粉钠%细胞免疫%体液免疫
呼吸道感染%兒童%羧甲澱粉鈉%細胞免疫%體液免疫
호흡도감염%인동%최갑정분납%세포면역%체액면역
Respiratory tract infection%Child%Sodium Starch Glycolate%Cell immunologic function%Humoral immunological
目的 探讨羧甲淀粉钠对反复呼吸道感染(RRI)患儿细胞、体液免疫功能及疗效的影响.方法 选择RRI患儿50例(治疗组)予以羧甲淀粉钠溶液口服,连用12周.比较患儿治疗前后细胞及体液免疫功能的变化,并进行临床疗效及药物不良反应观察.选择同期儿内科门诊治疗的非RRI的急性呼吸道感染患儿30例作为对照组.结果 治疗组患儿治疗前血清CD4+水平和CD4+/CD8+比值明显低于对照组,而CD8水平明显高于对照组(=2.27、2.25、2.91,P＜0.05或P＜0.01).治疗12周后,患儿血清CD4+水平和CD4+/CD8+比值明显上升,而CD8+水平明显下降(t=2.12、2.17、2.43,均P＜0.05).治疗组治疗前血清免疫球蛋白IgG、IgA和IgM水平明显低于对照组(=2.45、2.91、2.44,P＜0.05或P＜0.01).治疗12周后,患儿血清IgG、IgA和IgM水平均明显上升(t=2.14、2.25、2.31,均P＜0.05)；治疗组患儿治疗12周后,总有效率高达96.0％ (48/50),治疗期间未发生明显的药物不良反应事件.结论 羧甲淀粉钠治疗儿童RRI具有较好的效果及安全性,作用机制与调节T淋巴细胞亚群和免疫球蛋白水平紊乱,增强儿童的细胞和体液免疫功能密切相关.
目的 探討羧甲澱粉鈉對反複呼吸道感染(RRI)患兒細胞、體液免疫功能及療效的影響.方法 選擇RRI患兒50例(治療組)予以羧甲澱粉鈉溶液口服,連用12週.比較患兒治療前後細胞及體液免疫功能的變化,併進行臨床療效及藥物不良反應觀察.選擇同期兒內科門診治療的非RRI的急性呼吸道感染患兒30例作為對照組.結果 治療組患兒治療前血清CD4+水平和CD4+/CD8+比值明顯低于對照組,而CD8水平明顯高于對照組(=2.27、2.25、2.91,P＜0.05或P＜0.01).治療12週後,患兒血清CD4+水平和CD4+/CD8+比值明顯上升,而CD8+水平明顯下降(t=2.12、2.17、2.43,均P＜0.05).治療組治療前血清免疫毬蛋白IgG、IgA和IgM水平明顯低于對照組(=2.45、2.91、2.44,P＜0.05或P＜0.01).治療12週後,患兒血清IgG、IgA和IgM水平均明顯上升(t=2.14、2.25、2.31,均P＜0.05)；治療組患兒治療12週後,總有效率高達96.0％ (48/50),治療期間未髮生明顯的藥物不良反應事件.結論 羧甲澱粉鈉治療兒童RRI具有較好的效果及安全性,作用機製與調節T淋巴細胞亞群和免疫毬蛋白水平紊亂,增彊兒童的細胞和體液免疫功能密切相關.
목적 탐토최갑정분납대반복호흡도감염(RRI)환인세포、체액면역공능급료효적영향.방법 선택RRI환인50례(치료조)여이최갑정분납용액구복,련용12주.비교환인치료전후세포급체액면역공능적변화,병진행림상료효급약물불량반응관찰.선택동기인내과문진치료적비RRI적급성호흡도감염환인30례작위대조조.결과 치료조환인치료전혈청CD4+수평화CD4+/CD8+비치명현저우대조조,이CD8수평명현고우대조조(=2.27、2.25、2.91,P＜0.05혹P＜0.01).치료12주후,환인혈청CD4+수평화CD4+/CD8+비치명현상승,이CD8+수평명현하강(t=2.12、2.17、2.43,균P＜0.05).치료조치료전혈청면역구단백IgG、IgA화IgM수평명현저우대조조(=2.45、2.91、2.44,P＜0.05혹P＜0.01).치료12주후,환인혈청IgG、IgA화IgM수평균명현상승(t=2.14、2.25、2.31,균P＜0.05)；치료조환인치료12주후,총유효솔고체96.0％ (48/50),치료기간미발생명현적약물불량반응사건.결론 최갑정분납치료인동RRI구유교호적효과급안전성,작용궤제여조절T림파세포아군화면역구단백수평문란,증강인동적세포화체액면역공능밀절상관.
Objective To explore the curative effect of Sodium Starch Glycolate on children with recurrent respiratory tract infection(RRI) and its influence on cellular and humoral immunologic function.Methods 50 RRI children were selected as treatment group and treated by Sodium Starch Glycolate orally for 12 weeks.The changes of cellular and humoral immunologic function before and after treatment,and the curative effect and adverse reaction were observed.Another 3 0 non RRI but ARI children who received outpatient medical treatment during the same period were selected as control group.Results Before treatment,the level of CD4+ and CD4+/CD8+ of treatment group were significantly lower than that of control group,but the level of CD8+ was the opposite(t =2.27,2.25,2.91,P ＜0.05 or P ＜0.01).After treatment for 12 weeks,the level of CD4+ and CD4+/CD8+ of treatment group increased significantly compared with before treatment,but the level of CD8+ reduced significantly (t =2.12,2.17,2.43,all P ＜ 0.05).The plasma levels of IgG,IgA and IgM of treatment group were significantly lower than those of the control group before treatment (t =2.45,2.91,2.44,P ＜ 0.05 or P ＜ 0.01).After treatment for 12 weeks,the levels of IgG,IgA and IgM of treatment group increased significantly(t =2.14,2.25,2.31,all P ＜ 0.05),and the total effective rate was up to 96.0％ (48/50).No obvious adverse reaction occurred during treatment.Conclusion Sodium Starch Glycolate in treating RRI children shows good effect and high safety,which maybe relate with regulating the imbalance of the T cell subsets and immune globulin and enhancing the cellular and humoral immunologic function.
