中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
22期
3406-3407
,共2页
更昔洛韦%利巴韦林%脑炎,病毒性%儿童
更昔洛韋%利巴韋林%腦炎,病毒性%兒童
경석락위%리파위림%뇌염,병독성%인동
Ganciclovir%Ribavirin%Encephalitis,viral%Child
目的 观察更昔洛韦治疗小儿病毒性脑炎的临床疗效.方法 80例病毒性脑炎患儿按数字表法随机分为观察组40例和对照组40例,两组患儿均采用抗痉挛、脱水、控制体温、降低颅内高压及给予改善脑代谢药物等综合治疗,观察组在综合治疗基础上采用更昔洛韦静脉滴注,对照组在综合治疗基础上采用利巴韦林静脉滴注,观察两组临床疗效、主要临床症状消失时间及不良反应发生情况并进行比较.结果 观察组总有效率为92.5％,对照组总有效率为70.0％,两组总有效率差异有统计学意义(x2 =6.721,P＜0.05).观察组发热、头痛、呕吐、抽搐及意识障碍消失时间较对照组明显缩短(t=5.270、9.730、5.749、5.903、5.421,均P＜0.05).观察组不良反应发生率为7.5％,低于对照组的17.5％,但差异无统计学意义(P＞0.05).结论 更昔洛韦治疗小儿病毒性脑炎可在短时间内改善患儿临床症状,疗效显著,不良反应轻微,可作为小儿病毒性脑炎治疗的理想选择.
目的 觀察更昔洛韋治療小兒病毒性腦炎的臨床療效.方法 80例病毒性腦炎患兒按數字錶法隨機分為觀察組40例和對照組40例,兩組患兒均採用抗痙攣、脫水、控製體溫、降低顱內高壓及給予改善腦代謝藥物等綜閤治療,觀察組在綜閤治療基礎上採用更昔洛韋靜脈滴註,對照組在綜閤治療基礎上採用利巴韋林靜脈滴註,觀察兩組臨床療效、主要臨床癥狀消失時間及不良反應髮生情況併進行比較.結果 觀察組總有效率為92.5％,對照組總有效率為70.0％,兩組總有效率差異有統計學意義(x2 =6.721,P＜0.05).觀察組髮熱、頭痛、嘔吐、抽搐及意識障礙消失時間較對照組明顯縮短(t=5.270、9.730、5.749、5.903、5.421,均P＜0.05).觀察組不良反應髮生率為7.5％,低于對照組的17.5％,但差異無統計學意義(P＞0.05).結論 更昔洛韋治療小兒病毒性腦炎可在短時間內改善患兒臨床癥狀,療效顯著,不良反應輕微,可作為小兒病毒性腦炎治療的理想選擇.
목적 관찰경석락위치료소인병독성뇌염적림상료효.방법 80례병독성뇌염환인안수자표법수궤분위관찰조40례화대조조40례,량조환인균채용항경련、탈수、공제체온、강저로내고압급급여개선뇌대사약물등종합치료,관찰조재종합치료기출상채용경석락위정맥적주,대조조재종합치료기출상채용리파위림정맥적주,관찰량조림상료효、주요림상증상소실시간급불량반응발생정황병진행비교.결과 관찰조총유효솔위92.5％,대조조총유효솔위70.0％,량조총유효솔차이유통계학의의(x2 =6.721,P＜0.05).관찰조발열、두통、구토、추휵급의식장애소실시간교대조조명현축단(t=5.270、9.730、5.749、5.903、5.421,균P＜0.05).관찰조불량반응발생솔위7.5％,저우대조조적17.5％,단차이무통계학의의(P＞0.05).결론 경석락위치료소인병독성뇌염가재단시간내개선환인림상증상,료효현저,불량반응경미,가작위소인병독성뇌염치료적이상선택.
Objective To observe the clinical efficacy of ganciclovir in treatment of children with viral encephalitis.Methods 80 children with viral encephalitis were randomly divided into observation group and control group.All patients received the comprehensive treatment including anti-spasm,dehydration,control of body temperature,decreased intracranial pressure and drugs of improving brain metabolism.40 children in the observation group received intravenous ganciclovir.40 patients in the control group received intravenous ribavirin.The clinical effect of the two groups was compared.Results The total effective rate of observation group was 92.5％,that of the control group was 70.0％,the difference was statistically significant (x2 =6.721,P ＜ 0.05).In the observation group,the main clinical symptoms including fever,headache,vomiting,convulsions and the disappearance time of unconsciousness were significantly shorter than the control group(t =5.270,9.730,5.749,5.903,5.421,all P ＜ 0.05).The incidence rate of adverse reactions in the observation group was 7.5％,which was lower than 17.5％ in the control group,but the difference was not statistically significant (all P ＞ 0.05).Conclusion Ganciclovir in the treatment of children with viral encephalitis can improve clinical symptoms in a short time,and adverse reactions are mild,which can be used as the ideal choice for treatment of children with viral encephalitis.
