中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
22期
3425-3427
,共3页
2型糖尿病%炎症因子%胰岛素分泌指数%辩证分型
2型糖尿病%炎癥因子%胰島素分泌指數%辯證分型
2형당뇨병%염증인자%이도소분비지수%변증분형
Type 2 diabetes%Inflammatory factors%Insulin secretion index%Dialectical typing
目的 比较不同中医证型2型糖尿病患者血清超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平、胰岛素分泌指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)等指标的变化.方法 收集初发2型糖尿病患者63例,按中医证型分为痰热互结、气阴两虚、阴阳两虚三组,另设20例健康体检者为对照组,测定各组研究对象血清hs-CRP、IL-6及空腹血糖、胰岛素水平.结果 对照组hs-CRP、IL-6、胰岛素抵抗指数水平均低于糖尿病各中医证型组,差异有统计学意义(t=6.948,P ＜0.05).各证型组间胰岛素抵抗指数差异无统计学意义.对照组胰岛素分泌指数与痰热互结组比较差异无统计学意义(t=4.832,P＞0.05).各中医证型组间IL-6差异有统计学意义(t=4.985,P＜0.05).HOMA-β在各中医证型组间的差异有统计学意义(=5.043,P＜0.05),从高到低依次为痰热互结组＞气阴两虚组＞阴阳两虚组.结论 IL-6的变化与中医证型有关,中医证型变化的过程中伴随着胰岛功能的变化,IL-6、胰岛素分泌指数可作为中医辨证分型的参考依据.
目的 比較不同中醫證型2型糖尿病患者血清超敏C-反應蛋白(hs-CRP)、白細胞介素-6(IL-6)水平、胰島素分泌指數(HOMA-β)、胰島素牴抗指數(HOMA-IR)等指標的變化.方法 收集初髮2型糖尿病患者63例,按中醫證型分為痰熱互結、氣陰兩虛、陰暘兩虛三組,另設20例健康體檢者為對照組,測定各組研究對象血清hs-CRP、IL-6及空腹血糖、胰島素水平.結果 對照組hs-CRP、IL-6、胰島素牴抗指數水平均低于糖尿病各中醫證型組,差異有統計學意義(t=6.948,P ＜0.05).各證型組間胰島素牴抗指數差異無統計學意義.對照組胰島素分泌指數與痰熱互結組比較差異無統計學意義(t=4.832,P＞0.05).各中醫證型組間IL-6差異有統計學意義(t=4.985,P＜0.05).HOMA-β在各中醫證型組間的差異有統計學意義(=5.043,P＜0.05),從高到低依次為痰熱互結組＞氣陰兩虛組＞陰暘兩虛組.結論 IL-6的變化與中醫證型有關,中醫證型變化的過程中伴隨著胰島功能的變化,IL-6、胰島素分泌指數可作為中醫辨證分型的參攷依據.
목적 비교불동중의증형2형당뇨병환자혈청초민C-반응단백(hs-CRP)、백세포개소-6(IL-6)수평、이도소분비지수(HOMA-β)、이도소저항지수(HOMA-IR)등지표적변화.방법 수집초발2형당뇨병환자63례,안중의증형분위담열호결、기음량허、음양량허삼조,령설20례건강체검자위대조조,측정각조연구대상혈청hs-CRP、IL-6급공복혈당、이도소수평.결과 대조조hs-CRP、IL-6、이도소저항지수수평균저우당뇨병각중의증형조,차이유통계학의의(t=6.948,P ＜0.05).각증형조간이도소저항지수차이무통계학의의.대조조이도소분비지수여담열호결조비교차이무통계학의의(t=4.832,P＞0.05).각중의증형조간IL-6차이유통계학의의(t=4.985,P＜0.05).HOMA-β재각중의증형조간적차이유통계학의의(=5.043,P＜0.05),종고도저의차위담열호결조＞기음량허조＞음양량허조.결론 IL-6적변화여중의증형유관,중의증형변화적과정중반수착이도공능적변화,IL-6、이도소분비지수가작위중의변증분형적삼고의거.
Objective To compare the changes of hs-CRP,IL-6 level,insulin secretion index (HOMA-β),insulin resistance index (HOMA-IR) in the different TCM Hou of type 2 diabetic patients.Methods 63 newly diagnosed type 2 diabetic patients were selected.According to the TCM syndrome,they were divided into combination of phlegm and heat,deficiency of both qi and yin,yin and yang deficiency three groups.20 healthy people were selected as control group.The serum hs-CRP,IL-6 and fasting blood glucose,insulin were measured.Results The levels of hs-CRP,IL-6 and insulin resistance index were lower than the other three groups,there were significant differences (t =6.948,P ＜ 0.05).There was no significant difference in insulin secretion index between the control group and the combination of phlegm and heat gruop (t =4.832,P ＞ 0.05).There were significant differences in IL-6 level and HOMA-β among different syndromes groups(t =4.985,5.043,P ＜0.05).HOMA-β from high to low was the combination of phlegm and heat group ＞ deficiency of both qi and yin group ＞ yin and yang deficiency group.Conclusion The change of IL-6 correlates with TCM syndromes,and the change of TCM syndrome with the change of islet function.IL-6 and insulin secretion index can be used as reference of TCM type.
