中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
1期
8-9
,共2页
消化性溃疡%白细胞介素10%白细胞介素17
消化性潰瘍%白細胞介素10%白細胞介素17
소화성궤양%백세포개소10%백세포개소17
Peptic ulcer%Interlukin-10%Interlukin-17
目的 观察采用含铋剂的序贯疗法对消化性溃疡患者血清IL-10和IL-17的影响.方法 162例消化性溃疡患者按数字表法随机分为观察组81例和对照组81例.观察组采用含铋剂的序贯疗法治疗,对照组采用传统三联疗法治疗.治疗前后测定患者血清IL-10和IL-17的表达.结果 观察组总有效率为97.5%,对照组总有效率为87.7%,两组总有效率差异有统计学意义(x2 =3.96,P＜0.05).观察组幽门螺杆菌(Hp)根除率为96.3%,对照组Hp根除率为80.2%,两组差异有统计学意义(x2=4.17,P＜0.05).两组治疗后血清IL-10和IL-17均明显降低,与对照组比较,观察组降低程度更明显(t=3.7244、9.3422,均P＜0.05).结论 采用含铋剂的序贯疗法明显降低消化性溃疡患者血清IL-10和IL-17.
目的 觀察採用含鉍劑的序貫療法對消化性潰瘍患者血清IL-10和IL-17的影響.方法 162例消化性潰瘍患者按數字錶法隨機分為觀察組81例和對照組81例.觀察組採用含鉍劑的序貫療法治療,對照組採用傳統三聯療法治療.治療前後測定患者血清IL-10和IL-17的錶達.結果 觀察組總有效率為97.5%,對照組總有效率為87.7%,兩組總有效率差異有統計學意義(x2 =3.96,P＜0.05).觀察組幽門螺桿菌(Hp)根除率為96.3%,對照組Hp根除率為80.2%,兩組差異有統計學意義(x2=4.17,P＜0.05).兩組治療後血清IL-10和IL-17均明顯降低,與對照組比較,觀察組降低程度更明顯(t=3.7244、9.3422,均P＜0.05).結論 採用含鉍劑的序貫療法明顯降低消化性潰瘍患者血清IL-10和IL-17.
목적 관찰채용함필제적서관요법대소화성궤양환자혈청IL-10화IL-17적영향.방법 162례소화성궤양환자안수자표법수궤분위관찰조81례화대조조81례.관찰조채용함필제적서관요법치료,대조조채용전통삼련요법치료.치료전후측정환자혈청IL-10화IL-17적표체.결과 관찰조총유효솔위97.5%,대조조총유효솔위87.7%,량조총유효솔차이유통계학의의(x2 =3.96,P＜0.05).관찰조유문라간균(Hp)근제솔위96.3%,대조조Hp근제솔위80.2%,량조차이유통계학의의(x2=4.17,P＜0.05).량조치료후혈청IL-10화IL-17균명현강저,여대조조비교,관찰조강저정도경명현(t=3.7244、9.3422,균P＜0.05).결론 채용함필제적서관요법명현강저소화성궤양환자혈청IL-10화IL-17.
Objective To study the effects of containing bismuth sequential therapy on interleukin-10 (IL-10) and interleukin-17 (IL-17) in patients with peptic ulcer.Methods 162 patients with peptic ulcer were randomly divided into two groups,the observation group(n =81 cases) and the control group (n =81 cases).The patients in the observation group were treated through containing bismuth sequential therapy,while the patients in the control group were treated through traditional triple therapy.IL-10 and IL-17 were detected before and after treatment.Results The total effective rates were 97.5% in the observation group and 87.7% in the control group,which of the two groups had significantly difference (x2 =3.96,P ＜ 0.05).Hp eradication rate of the observation group was 96.3 %,and which of the control group was 80.2%,and there was significant difference between the two groups (x2 =4.17,P ＜ 0.05).IL-10 and IL-17 in both groups were significantly decreased after treatment.There was a significant difference between two groups after treatment (t =3.7244,9.3422,all P ＜ 0.05).Conclusion Bismuth-containing sequential therapy can significantly reduce IL-10 and IL-17 in the serum of patients with peptic ulcer.
