中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
1期
14-16
,共3页
耐药%呋喃妥因%革兰阴性杆菌
耐藥%呋喃妥因%革蘭陰性桿菌
내약%부남타인%혁란음성간균
Drug resistance%Nitrofurantoin%Gram-negative bacteria
目的 了解呋喃妥因对革兰阴性杆菌的抗菌活性,为临床合理使用呋喃妥因提供依据.方法 监测某医院2009年1月至2012年12月临床分离的革兰阴性杆菌5 589株；采用VITEK 2 Compact全自动细菌培养鉴定仪进行细菌鉴定和药敏试验,以Whonet 5.6软件进行数据分析.结果 大肠埃希菌和产酸克雷伯菌对呋喃妥因的抗菌活性较好(耐药率＜4.3%),阴沟肠杆菌和肺炎克雷伯菌对呋喃妥因的抗菌活性尚好(耐药率25.6%～36.3%),铜绿假单胞菌、鲍曼不动杆菌、奇异变形菌和黏质沙雷菌对呋喃妥因的抗菌活性较差(耐药率93.7%～98.9%),耐亚胺培南铜绿假单胞菌(IRPA)、耐碳青霉烯类抗菌药物鲍曼不动杆菌(CR-AB)和耐碳青霉烯类抗菌药物肠杆菌科细菌(CRE)对呋喃妥因的耐药率分别为100.0%(108/108)、100.0% (335/335)和96.1% (74/77).结论 呋喃妥因对尿液、血液、脓汁和分泌物标本中分离的大肠埃希菌的抗菌活性较好；痰液标本中分离的铜绿假单胞菌和鲍曼不动杆菌对呋喃妥因的耐药率较高.
目的 瞭解呋喃妥因對革蘭陰性桿菌的抗菌活性,為臨床閤理使用呋喃妥因提供依據.方法 鑑測某醫院2009年1月至2012年12月臨床分離的革蘭陰性桿菌5 589株；採用VITEK 2 Compact全自動細菌培養鑒定儀進行細菌鑒定和藥敏試驗,以Whonet 5.6軟件進行數據分析.結果 大腸埃希菌和產痠剋雷伯菌對呋喃妥因的抗菌活性較好(耐藥率＜4.3%),陰溝腸桿菌和肺炎剋雷伯菌對呋喃妥因的抗菌活性尚好(耐藥率25.6%～36.3%),銅綠假單胞菌、鮑曼不動桿菌、奇異變形菌和黏質沙雷菌對呋喃妥因的抗菌活性較差(耐藥率93.7%～98.9%),耐亞胺培南銅綠假單胞菌(IRPA)、耐碳青黴烯類抗菌藥物鮑曼不動桿菌(CR-AB)和耐碳青黴烯類抗菌藥物腸桿菌科細菌(CRE)對呋喃妥因的耐藥率分彆為100.0%(108/108)、100.0% (335/335)和96.1% (74/77).結論 呋喃妥因對尿液、血液、膿汁和分泌物標本中分離的大腸埃希菌的抗菌活性較好；痰液標本中分離的銅綠假單胞菌和鮑曼不動桿菌對呋喃妥因的耐藥率較高.
목적 료해부남타인대혁란음성간균적항균활성,위림상합리사용부남타인제공의거.방법 감측모의원2009년1월지2012년12월림상분리적혁란음성간균5 589주；채용VITEK 2 Compact전자동세균배양감정의진행세균감정화약민시험,이Whonet 5.6연건진행수거분석.결과 대장애희균화산산극뢰백균대부남타인적항균활성교호(내약솔＜4.3%),음구장간균화폐염극뢰백균대부남타인적항균활성상호(내약솔25.6%～36.3%),동록가단포균、포만불동간균、기이변형균화점질사뢰균대부남타인적항균활성교차(내약솔93.7%～98.9%),내아알배남동록가단포균(IRPA)、내탄청매희류항균약물포만불동간균(CR-AB)화내탄청매희류항균약물장간균과세균(CRE)대부남타인적내약솔분별위100.0%(108/108)、100.0% (335/335)화96.1% (74/77).결론 부남타인대뇨액、혈액、농즙화분비물표본중분리적대장애희균적항균활성교호；담액표본중분리적동록가단포균화포만불동간균대부남타인적내약솔교고.
Objective To understand the antibacterial activity of nitrofurantoin from gram negative bacilli,provide the basis for clinical rational use of furan appropriate for drugs.Methods Gram negative bacilli 5 589 strains isolated from clinical were monitored between January 2009 and December 2009.VITEK 2 Compact automatic bacteria identification instrument was used for bacteria identification and drug sensitive test.Whonet 5.6 software was used for data analysis.Results E.coli and klebsiella bacteria produced acid with nitrofurantoin had good antibacterial activity (resistance to ＜ 4.3%),E.coli and klebsiella pneumoniae to with nitrofurantoin for antimicrobial activity was good (the percentages of 25.6% ～ 25.6%),pseudomonas aeruginosa,acinetobacter baumannii,singular deformation bacteria and glue abdulrahman al saleh,bacterium antibacterial activity of furan appropriate for poorer(ni 93.7% ～ 98.9%).Imine resistance from south pseudomonas aeruginosa (IRPA),resistant to carbon penicillium alkene antimicrobial acinetobacter baumannii(CR-AB) and penicillium carbon alkene antimicrobial drug resistant enterobacteriaceae bacteria(CRE) with nitrofurantoin because of the percentages were 100.0% (108/108),100.0% (335/335) and 96.1% (74/77).Conclusion Urine,blood,pus,and secretion of primary separation of E.coli with nitrofurantoin has better antimicrobial activity; Sputum specimens of primary separation of pseudomonas aeruginosa and acinetobacter baumannii with nitrofurantoin has the high prevalence of resistance.
