中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
12期
1763-1765
,共3页
脂肪肝%生化现象%危险因素
脂肪肝%生化現象%危險因素
지방간%생화현상%위험인소
Fatty liver%Biochemical phenomena%Risk factors
目的 观察分析非酒精性脂肪性肝病(NAFLD)的血清生化指标,结合患者的生活方式,总结探讨诱发该病的危险因素.方法 选择门诊和住院确诊的NAFLD患者共258例,同期非脂肪性肝病体检者213例为对照组.分别进行血清生化指标检测和生活习惯调查.结果 NAFLD组的生化指标TC(5.48±1.10) mmol/L、TG(2.31±1.25) mmol/L、ALT(51.35±26.18)U/L、AST(42.37±28.32) U/L、空腹血糖(FPG)(5.62±3.24) mmol/L、γ-谷氨酰转肽酶(GGT)(58.47±43.25)U/L、尿酸(UA) (398.51±96.85) μmol/L均高于对照组(t=3.423、5.250、7.402、4.348、3.326、6.683、3.891,均P＜0.01);高血压(21.71％)、糖尿病(22.09％)、代谢综合征(MS,44.57％)等发生率及BMI(26.85±3.45)均明显高于对照组(x2=8.14、10.55、58.48,t=10.73,均P＜0.01).多因素Logistic回归分析中,TG、腰围(WI)、BMI、胰岛素抵抗指数(HOMA-IR)、缺少锻炼、高脂饮食是NAFLD的独立危险因素(均P＜0.05).结论 NAFLD患者与代谢异常密切相关,合理的饮食和健康的生活方式是防治该病的有效途径.
目的 觀察分析非酒精性脂肪性肝病(NAFLD)的血清生化指標,結閤患者的生活方式,總結探討誘髮該病的危險因素.方法 選擇門診和住院確診的NAFLD患者共258例,同期非脂肪性肝病體檢者213例為對照組.分彆進行血清生化指標檢測和生活習慣調查.結果 NAFLD組的生化指標TC(5.48±1.10) mmol/L、TG(2.31±1.25) mmol/L、ALT(51.35±26.18)U/L、AST(42.37±28.32) U/L、空腹血糖(FPG)(5.62±3.24) mmol/L、γ-穀氨酰轉肽酶(GGT)(58.47±43.25)U/L、尿痠(UA) (398.51±96.85) μmol/L均高于對照組(t=3.423、5.250、7.402、4.348、3.326、6.683、3.891,均P＜0.01);高血壓(21.71％)、糖尿病(22.09％)、代謝綜閤徵(MS,44.57％)等髮生率及BMI(26.85±3.45)均明顯高于對照組(x2=8.14、10.55、58.48,t=10.73,均P＜0.01).多因素Logistic迴歸分析中,TG、腰圍(WI)、BMI、胰島素牴抗指數(HOMA-IR)、缺少鍛煉、高脂飲食是NAFLD的獨立危險因素(均P＜0.05).結論 NAFLD患者與代謝異常密切相關,閤理的飲食和健康的生活方式是防治該病的有效途徑.
목적 관찰분석비주정성지방성간병(NAFLD)적혈청생화지표,결합환자적생활방식,총결탐토유발해병적위험인소.방법 선택문진화주원학진적NAFLD환자공258례,동기비지방성간병체검자213례위대조조.분별진행혈청생화지표검측화생활습관조사.결과 NAFLD조적생화지표TC(5.48±1.10) mmol/L、TG(2.31±1.25) mmol/L、ALT(51.35±26.18)U/L、AST(42.37±28.32) U/L、공복혈당(FPG)(5.62±3.24) mmol/L、γ-곡안선전태매(GGT)(58.47±43.25)U/L、뇨산(UA) (398.51±96.85) μmol/L균고우대조조(t=3.423、5.250、7.402、4.348、3.326、6.683、3.891,균P＜0.01);고혈압(21.71％)、당뇨병(22.09％)、대사종합정(MS,44.57％)등발생솔급BMI(26.85±3.45)균명현고우대조조(x2=8.14、10.55、58.48,t=10.73,균P＜0.01).다인소Logistic회귀분석중,TG、요위(WI)、BMI、이도소저항지수(HOMA-IR)、결소단련、고지음식시NAFLD적독립위험인소(균P＜0.05).결론 NAFLD환자여대사이상밀절상관,합리적음식화건강적생활방식시방치해병적유효도경.
Objective To observe the biochemical indicators and lifestyles of patients with non-alcoholic fatty liver disease (NAFLD),and analyse the risk factors of induced NAFLD.Methods A total of 258 in-and out-patients of NAFLD were included in the present study,the control group consisted of 213 examinationers with nonfatty liver disease.All samples were being blood biochemical indicator detection and lifestyle survey.Results Some blood biochemical index of NAFLD patients such as TC(5.48 ± 1.10) mmol/L,TG(2.31 ± 1.25) mmol/L,ALT (51.35 ± 26.18) U/L,AST (42.37 ± 28.32) U/L,FPG (5.62 ± 3.24) mmol/L,GGT (58.47 ± 43.25) U/L and UA (398.51 ± 96.85) μmol/L were higher than those of the control group (t =3.423,5.250,7.402,4.348,3.326,6.683,3.891,all P ＜ 0.01) ; and the incidence of hyperlipidemia,hypertension (21.71％),diabetes (22.09％),BMI(26.85 ± 3.45) or metabolic syndrome (44.57％) etc.Those indexes in NAFLD patients were significantly higher than those in the control group (x2 =8.14,10.55,58.48,t =10.73,all P ＜ 0.01).By multivariable Logistic regression analysis,TG,WI,BMI,HOMA-IR,lack of exercise,high-fat diet were independent risk factors for NAFLD (all P ＜ 0.05).Conclusion Patients with NAFLD is closely correlated to metabolic abnormalities,reasonable diet and a healthy lifestyle is an effective way of prevention and treatment of this disease.
