CAJ | 학술논문

目的探讨急性心肌梗死(AMI)患者早期快速测定血浆N-末端B型利钠肽原(NT-proBNP)的水平对临床预后的判断价值.方法选择56例符合诊断的AMI患者,入院早期快速测定血浆NT-proBNP的水平,根据血浆NT-proBNP的水平分成三组:A组＜500 ng/L,B组500～2 000 ng/L,C组＞2 000 ng/L,观察三组在住院期间、30 d发生心血管不良事件情况(严重心律失常、充血性心力衰竭、心源性休克及死亡).结果三组住院期间、30 d发生心血管不良事件情况(A组1例、0例,B组3例、1例,C组8例、6例)明显不同(x2=6.705,P=0.035;x2=7.957,P=0.008).三组发生心血管不良事件发生率呈递增趋势,分别为6.6％,18.18％,73.69％.结论 AMI患者早期快速测定血浆NT-proBNP水平,对评估AMI患者近期临床预后及指导治疗具有重要临床价值.
목적 탐토급성심기경사(AMI)환자조기쾌속측정혈장N-말단B형리납태원(NT-proBNP)적수평대림상예후적판단개치.방법 선택56례부합진단적AMI환자,입원조기쾌속측정혈장NT-proBNP적수평,근거혈장NT-proBNP적수평분성삼조:A조＜500 ng/L,B조500～2 000 ng/L,C조＞2 000 ng/L,관찰삼조재주원기간、30 d발생심혈관불량사건정황(엄중심률실상、충혈성심력쇠갈、심원성휴극급사망).결과 삼조주원기간、30 d발생심혈관불량사건정황(A조1례、0례,B조3례、1례,C조8례、6례)명현불동(x2=6.705,P=0.035;x2=7.957,P=0.008).삼조발생심혈관불량사건발생솔정체증추세,분별위6.6％,18.18％,73.69％.결론 AMI환자조기쾌속측정혈장NT-proBNP수평,대평고AMI환자근기림상예후급지도치료구유중요림상개치.
Objective To explore the clinical prognostic value of rapid detection for plasma NT-proBNP levels on admission in patients with acute myocardial infarction.Methods 56 patients with AMI were measured plasma NT-proBNP imediately in hospital,and then they were divided into A,B and C group according to NT-proBNP levels (A group:＜ 500ng/L,B group:500-2 000ng/L,C group:＞ 2 000ng/L).The incidence of major adverse cardiac events (MACE including congestive heart failure,malignant arrhythmia,cardiogenic shock and sudden cardiac death) in subjects were observed respectively during hospitalisation and 30 days.Results The three group subjects with different NT-proBNP levels presented different incidence of MACE(A group:1,0;B group:3,1;C group:8,6) at duration of hospital stay,30days (x2 =6.705,P =0.035 ; x2 =7.957,P =0.008).With the NT-proBNP levels rising in AMI paitents,the inciedence of MACE increased.The incidence of MACE in A,B and C group were 6.6％,18.18％ and 73.69％ respectively.Conclusion In AMI patients,plasma NT-proBNP levels could predict early MACE incidence,which has an important value to evaluate the early clinical prognosis.