中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
12期
1782-1784
,共3页
卵巢肿瘤%Pokemon蛋白%p53蛋白
卵巢腫瘤%Pokemon蛋白%p53蛋白
란소종류%Pokemon단백%p53단백
Ovarian Neoplasms%Pokemon protein%p53 protein
目的 探讨卵巢癌组织中Pokemon蛋白和p53蛋白表达,明确其与临床病理的关系.方法 选取52例卵巢癌组织作为观察组,60例卵巢良性病变组织作为对照组.免疫组化测定两组组织中Pokemon蛋白和p53蛋白的表达.结果 观察组和对照组中Pokemon蛋白阳性率分别为69.2％(36/52)和11.7％(7/60),差异有统计学意义(x2=12..74,P＜0.01).观察组和对照组中p53蛋白阳性率分别为78.8％ (41/52)和15.0％(9/60),差异有统计学意义(x2 =22.71,P＜0.01).Pokemon蛋白表达与卵巢癌患者的肿瘤浸润深度(x2=9.16,P＜0.05)、临床分期(x2=5.86,P＜0.05)、淋巴结是否转移(x2=32.28,P＜0.01)和是否复发(x2 =27.08,P ＜0.01)均有显著的关系,与肿瘤分化程度(x2=0.82,P ＞0.05)无明显关系.p53蛋白表达与卵巢癌患者的肿瘤浸润深度(x2 =8.24,P＜0.05)、临床分期(x2=9.24,P＜0.05)、淋巴结是否转移(x2=19.62,P ＜0.01)和是否复发(x2=21.16,P＜0.01)均有显著的关系,与肿瘤分化程度(x2 =0.77,P＞0.05)无明显关系.经相关性分析,Pokemon蛋白和p53蛋白阳性表达有明显正相关关系(r=0.297,P＜0.05).结论 Pokemon蛋白和p53蛋白与卵巢癌的诊断、病变程度和预后均有密切关系.
目的 探討卵巢癌組織中Pokemon蛋白和p53蛋白錶達,明確其與臨床病理的關繫.方法 選取52例卵巢癌組織作為觀察組,60例卵巢良性病變組織作為對照組.免疫組化測定兩組組織中Pokemon蛋白和p53蛋白的錶達.結果 觀察組和對照組中Pokemon蛋白暘性率分彆為69.2％(36/52)和11.7％(7/60),差異有統計學意義(x2=12..74,P＜0.01).觀察組和對照組中p53蛋白暘性率分彆為78.8％ (41/52)和15.0％(9/60),差異有統計學意義(x2 =22.71,P＜0.01).Pokemon蛋白錶達與卵巢癌患者的腫瘤浸潤深度(x2=9.16,P＜0.05)、臨床分期(x2=5.86,P＜0.05)、淋巴結是否轉移(x2=32.28,P＜0.01)和是否複髮(x2 =27.08,P ＜0.01)均有顯著的關繫,與腫瘤分化程度(x2=0.82,P ＞0.05)無明顯關繫.p53蛋白錶達與卵巢癌患者的腫瘤浸潤深度(x2 =8.24,P＜0.05)、臨床分期(x2=9.24,P＜0.05)、淋巴結是否轉移(x2=19.62,P ＜0.01)和是否複髮(x2=21.16,P＜0.01)均有顯著的關繫,與腫瘤分化程度(x2 =0.77,P＞0.05)無明顯關繫.經相關性分析,Pokemon蛋白和p53蛋白暘性錶達有明顯正相關關繫(r=0.297,P＜0.05).結論 Pokemon蛋白和p53蛋白與卵巢癌的診斷、病變程度和預後均有密切關繫.
목적 탐토란소암조직중Pokemon단백화p53단백표체,명학기여림상병리적관계.방법 선취52례란소암조직작위관찰조,60례란소량성병변조직작위대조조.면역조화측정량조조직중Pokemon단백화p53단백적표체.결과 관찰조화대조조중Pokemon단백양성솔분별위69.2％(36/52)화11.7％(7/60),차이유통계학의의(x2=12..74,P＜0.01).관찰조화대조조중p53단백양성솔분별위78.8％ (41/52)화15.0％(9/60),차이유통계학의의(x2 =22.71,P＜0.01).Pokemon단백표체여란소암환자적종류침윤심도(x2=9.16,P＜0.05)、림상분기(x2=5.86,P＜0.05)、림파결시부전이(x2=32.28,P＜0.01)화시부복발(x2 =27.08,P ＜0.01)균유현저적관계,여종류분화정도(x2=0.82,P ＞0.05)무명현관계.p53단백표체여란소암환자적종류침윤심도(x2 =8.24,P＜0.05)、림상분기(x2=9.24,P＜0.05)、림파결시부전이(x2=19.62,P ＜0.01)화시부복발(x2=21.16,P＜0.01)균유현저적관계,여종류분화정도(x2 =0.77,P＞0.05)무명현관계.경상관성분석,Pokemon단백화p53단백양성표체유명현정상관관계(r=0.297,P＜0.05).결론 Pokemon단백화p53단백여란소암적진단、병변정도화예후균유밀절관계.
Objective To explore the expression of Pokemon protein and p53 protein in ovarian carcinoma and assure the relationship with clinicopathologic parameters.Methods 52 cases of ovarian cancer were enrolled as the observation group,60 cases of benign ovarian tissue as the control group.Expression of Pokemon protein and p53 protein were detected by immunohistochemistry.Results The positive rate of Pokemon protein were respectively 69.2％ (36/52) in the observation group and 11.7％ (7/60) in the control group,a significant differences between the two groups (x2 =12.74,P ＜0.01).The positive rate of p53 protein were respectively 78.8％ (41/52) in the observation group and 15.0％ (9/60) in the control group,a significant differences between the two groups(x2 =22.71,P ＜ 0.01).Pokemon protein expression were associated with ovarian cancer tumor invasion depth (x2 =9.16,P ＜ 0.05),clinical stage(x2 =5.86,P ＜ 0.05),lymph node metastasis (x2 =32.28,P ＜ 0.01) and recurrence (x2 =27.08,P ＜ 0.01) and no significant relationship with tumor differentiation (x2 =0.82,P ＞ 0.05).p53 protein expression were associated with ovarian cancer tumor invasion depth (x2 =8.24,P ＜ 0.05),clinical stage (x2 =9.24,P ＜ 0.05),lymph node metastasis (x2 =19.62,P ＜ 0.01) and recurrence (x2 =21.16,P ＜ 0.01) and no significant relationship with tumor differentiation(x2 =0.77,P ＞0.05).By correlation analysis,Pokemon protein expression had a significant positive correlation and p53 protein(r =0.297,P ＜ 0.05).Conclusion Pokemon protein and p53 protein had closely related with diagnosis,lesion degree and prognosis in ovarian cancer.
