中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
12期
1785-1786
,共2页
心肌缺血%内皮缩血管肽1%单核细胞化学吸引蛋白质类%基质金属蛋白酶类
心肌缺血%內皮縮血管肽1%單覈細胞化學吸引蛋白質類%基質金屬蛋白酶類
심기결혈%내피축혈관태1%단핵세포화학흡인단백질류%기질금속단백매류
Myocardial ischemia%Endothelin-1%Monocyte chemoattractant proteins%Matrix metalloproteinases
目的 探讨血清内皮素(ET-1)、单核细胞趋化蛋白(MCP-1)和基质金属蛋白酶-9(MMP-9)水平与不同类型冠心病的关系.方法 80例冠心病患者,按不同类型分为急性心肌梗死(AMI)组22例、不稳定型心绞痛(UAP)组33例、稳定型心绞痛(SAP)组25例,另选择30例健康体检者作为对照组.采用ELISA法检测血清ET-1、MCP-1和MMP-9的水平,比较各组间的差异.结果 四组血清ET-1 (F=17.36)、MCP-1(F=13.51)和MMP-9(F=15.43)水平差异均有统计学意义(均P＜0.05).组间比较:AMI组、UAP组及SAP组较对照组高(t=5.12、5.35、5.15、4.22、4.65、4.54、3.12、3.65、3.54,均P＜0.05);AMI组、UAP组较SAP组高(t=4.32、4.15、4.52、3.54、3.23、3.51,均P＜0.05);AMI组较UAP组高(t=3.78、3.96、3.56,均P＜0.05).结论 血清ET-1、MCP-1和MMP-9可能是冠状动脉粥样硬化的标志,参与了冠心病的发病机制,与冠状动脉病变程度密切相关.
目的 探討血清內皮素(ET-1)、單覈細胞趨化蛋白(MCP-1)和基質金屬蛋白酶-9(MMP-9)水平與不同類型冠心病的關繫.方法 80例冠心病患者,按不同類型分為急性心肌梗死(AMI)組22例、不穩定型心絞痛(UAP)組33例、穩定型心絞痛(SAP)組25例,另選擇30例健康體檢者作為對照組.採用ELISA法檢測血清ET-1、MCP-1和MMP-9的水平,比較各組間的差異.結果 四組血清ET-1 (F=17.36)、MCP-1(F=13.51)和MMP-9(F=15.43)水平差異均有統計學意義(均P＜0.05).組間比較:AMI組、UAP組及SAP組較對照組高(t=5.12、5.35、5.15、4.22、4.65、4.54、3.12、3.65、3.54,均P＜0.05);AMI組、UAP組較SAP組高(t=4.32、4.15、4.52、3.54、3.23、3.51,均P＜0.05);AMI組較UAP組高(t=3.78、3.96、3.56,均P＜0.05).結論 血清ET-1、MCP-1和MMP-9可能是冠狀動脈粥樣硬化的標誌,參與瞭冠心病的髮病機製,與冠狀動脈病變程度密切相關.
목적 탐토혈청내피소(ET-1)、단핵세포추화단백(MCP-1)화기질금속단백매-9(MMP-9)수평여불동류형관심병적관계.방법 80례관심병환자,안불동류형분위급성심기경사(AMI)조22례、불은정형심교통(UAP)조33례、은정형심교통(SAP)조25례,령선택30례건강체검자작위대조조.채용ELISA법검측혈청ET-1、MCP-1화MMP-9적수평,비교각조간적차이.결과 사조혈청ET-1 (F=17.36)、MCP-1(F=13.51)화MMP-9(F=15.43)수평차이균유통계학의의(균P＜0.05).조간비교:AMI조、UAP조급SAP조교대조조고(t=5.12、5.35、5.15、4.22、4.65、4.54、3.12、3.65、3.54,균P＜0.05);AMI조、UAP조교SAP조고(t=4.32、4.15、4.52、3.54、3.23、3.51,균P＜0.05);AMI조교UAP조고(t=3.78、3.96、3.56,균P＜0.05).결론 혈청ET-1、MCP-1화MMP-9가능시관상동맥죽양경화적표지,삼여료관심병적발병궤제,여관상동맥병변정도밀절상관.
Objective To study the relationship of the levels of serum ET-1,MCP-1 and MMP-9 in patients with different type coronary heart disease (CHD).Methods 80 CHD patients were divided into 3 groups,including 22 cases of acute myocardial infarction (AMI),33 cases of unstable angina (UAP),25 cases of stable angina (SAP) and control group consisted of 30 healthy people.The levels of ET-1,MCP-1 and MMP-9 were measured by enzymelinked immunosorbent assay (ELISA).The levels of serum ET-1,MCP-1 and MMP-9 in different groups were compared.Results The serum levels of ET-1,MCP-1 and MMP-9 in AMI,UAP and SAP groups were significantly higher than those in the control group (t =5.12,5.35,5.15,4.22,4.65,4.54,3.12,3.65,3.54,all P ＜ 0.05).Compared with SAP group,the levels of ET-1,MCP-1 and MMP-9 were increased in AMI and UAP groups (t =4.32,4.15,4.52,3.54,3.23,3.51,all P ＜ 0.05).Compared with UAP group,the levels of ET-1,MCP-1 and MMP-9 were increased in AMI groups (t =3.78,3.96,3.56,all P ＜ 0.05).Conclusion Serum ET-1,MCP-1 and MMP-9 may be the markers of coronary atherosclerosis and involved in the process of CHD.The levels of serum ET-1,MCP-1 and MMP-9 are correlated with the severity of CHD.
