CAJ | 학술논문

目的分析急性白血病患儿真菌血症的菌群分布及耐药情况,为临床诊治提供参考.方法对42例恶性肿瘤真菌血症患儿的临床资料进行回顾性分析.结果 42例真菌血症中急性淋巴细胞白血病35例,急性非淋巴细胞白血病6例.念珠菌血症为真菌血症的主要病原体,占95.2％.8例合并细菌败血症,占19.0％.药物敏感试验结果显示,2例对氟康唑中介,1例对两性霉素B耐药,对伏立康唑、伊曲康唑、氟胞嘧啶均敏感.广谱抗生素的应用、中性粒细胞＜ 0.5×109/L、中心静脉置管、年龄、住院时间＞15 d是引起真菌血症最主要的危险因素.结论控制易感因素是降低真菌血症发病率的有效措施,及时合理的抗真菌治疗是治疗真菌血症的主要方法.
목적 분석급성백혈병환인진균혈증적균군분포급내약정황,위림상진치제공삼고.방법 대42례악성종류진균혈증환인적림상자료진행회고성분석.결과 42례진균혈증중급성림파세포백혈병35례,급성비림파세포백혈병6례.념주균혈증위진균혈증적주요병원체,점95.2％.8례합병세균패혈증,점19.0％.약물민감시험결과현시,2례대불강서중개,1례대량성매소B내약,대복립강서、이곡강서、불포밀정균민감.엄보항생소적응용、중성립세포＜ 0.5×109/L、중심정맥치관、년령、주원시간＞15 d시인기진균혈증최주요적위험인소.결론 공제역감인소시강저진균혈증발병솔적유효조시,급시합리적항진균치료시치료진균혈증적주요방법.
Objective To investigate the epidemiology of fungemia and provide evidence for clinical therapy.Methods A retrospective survey was done with the 42 cases of fungemia in our hospital.Results 42 cases of fungemia include 35 cases acute lymphoid leukemia,6 acute myloid leukemia.95.2％ of the fungemia pathogen agent was monilia.8 cases combined with bacterial septicemia,accounting for 19.0％.Drug sensitivity test showed that 2 cases were intermediary to Fluconazole,1 patient was resisdence to Amphotericin B but sensitive to Voriconazole,Itraconazole and fluorocytosine.The main risk factors of fungimia included using wide-spectrum antibiotic,neutophil less than 0.5 × 109/L,central venous indwelling catheter,age and the time of in hospital more than 15 days.Conclusion The effective measure to reduce fungemia morbitity is controlling risk factors.Timely and effectively antifungal therapy is also needed.